The additive effect of the triglyceride-glucose index and estimated glucose disposal rate on long-term mortality among individuals with and without diabetes: a population-based study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 22, 2024

The triglyceride-glucose (TyG) index and estimated glucose disposal rate (eGDR), which are calculated using different parameters, widely used as markers of insulin resistance associated with cardiovascular diseases prognosis. However, whether they have an additive effect on the risk mortality remains unclear. This study aimed to explore combined assessment TyG eGDR improved prediction long-term in individuals without diabetes. In this cross-sectional cohort study, data were derived from National Health Nutrition Examination Survey (NHANES) 2001–2018, death record information was obtained Death Index. associations all-cause determined by multivariate Cox regression analysis restricted cubic splines. Among 17,787 included analysis, there 1946 (10.9%) deaths 649 (3.6%) during a median follow-up 8.92 years. diabetes, spline curves for followed J-shape L-shape, respectively. significantly increased after > 9.04 (all-cause mortality) or 9.30 (cardiovascular mortality), < 4 mg/kg/min (both mortality). association between negative linear relationship. no mortality. Compared low high group, those group (TyG 4) showed highest (hazard ratio [HR] = 1.592, 95% confidence interval [CI] 1.284–1.975) (HR 1.683, CI 1.179-2.400) overall population. Similar results observed There potential provided additional prognostic contributed improving stratification.

Language: Английский

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The association between the triglyceride–glucose index and the risk of cardiovascular disease in US population aged ≤ 65 years with prediabetes or diabetes: a population-based study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 13, 2024

Abstract Background The relationship between the triglyceride–glucose (TyG) index and risk of cardiovascular disease (CVD) in U.S. population under 65 years age with diabetes or prediabetes is unknown. purpose this study was to investigate baseline TyG CVD patients prediabetes. Methods We used data from 2003–2018 National Health Nutrition Examination Survey (NHANES). Multivariate regression analysis models were constructed explore risk. Nonlinear correlations explored using restricted cubic splines. Subgroup interaction tests also conducted. Results enrolled a total 4340 participants pre-diabetes, mean 9.02 ± 0.02. overall average prevalence 10.38%. Participants higher quartiles showed high rates (Quartile 1: 7.35%; Quartile 2: 10.04%; 3: 10.71%; 4: 13.65%). For CVD, possible association observed. Our findings suggested linear CVD. results revealed U-shaped both (P nonlinear = 0.02583) CHF 0.0208) individuals diabetes. term indicated that there no significant difference among different stratifications. positive comorbid MetS Conclusions A linked an increased likelihood aged ≤ Besides, assessment will contribute more convenient effective screening high-risk MetS. Future studies should whether interventions targeting may improve clinical outcomes these patients.

Language: Английский

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Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 8, 2025

Among hypertensive cohorts across different nations, the relationship between triglyceride-glucose index (TyG) and its conjunction with obesity metrics in relation to cardiovascular disease (CVD) incidence mortality remains be elucidated. This study enrolled 9,283, 164,357, 5,334 hypertensives from National Health Nutrition Examination Survey (NHANES), UK Biobank (UKBB), Shanghai Pudong cohort. The related outcomes for CVD were defined by multivariate Cox proportional hazards models, Generalized Additive Models Mendelian randomization analysis. Mediation analysis explored mediating role of inflammatory markers above relationships. Five measures insulin resistance linked death a U-shaped pattern, highest group having risk increases. Higher glucose triglyceride-waist height ratio (TyG-WHTR) was higher all-cause (UKBB: HR 1.21, 95%CI 1.16–1.26, NHANES: 1.17, 1.00–1.36), 1.36, 1.23–1.49, 1.32, 1.00–1.72) risks. In China cohort, triglyceride/high-density lipoprotein-cholesterol (TG/HDL_C) associated risks stroke (HR 1.31, 1.00–1.73 1.67, 1.06–2.63). Inflammation like systemic response (SIRI) C-reactive protein (CRP) partially explained these links, CRP stronger effect. Genetically predicted TyG also (OR 1.26, 1.10–1.45) risk. An elevated indices are significantly correlated an increased three national cohorts. These anticipated serve as valid predictors incident individuals hypertension.

Language: Английский

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Triglyceride glucose index–body mass index as a predictor of coronary artery disease severity in patients with H-type hypertension across different glucose metabolic states

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 15, 2025

The triglyceride glucose-body mass index (TyG-BMI) is considered to be a reliable surrogate marker of insulin resistance (IR). However, limited evidence exists regarding its association with the severity coronary artery disease (CAD), particularly in hypertensive patients different glucose metabolic states, including those H-type hypertension. This study aimed investigate relationship between TyG-BMI and CAD across metabolism conditions. retrospective cohort included 1537 who underwent angiography. was categorized into tertiles analyzed using logistic regression models restricted cubic spline (RCS) assess multi-vessel CAD. Receiver operating characteristic (ROC) curves were used evaluate predictive value detecting normal regulation (NGR), pre-diabetes mellitus (Pre-DM), diabetes (DM). above method has also been applied populations hypertension patients. significantly associated (Odds ratio [OR] 1.043, 95% CI 1.032–1.053). In diabetic subgroup, after adjusting for risk factors, T3 groups 3.836-fold (95% 1.763–8.347; P = 0.001) higher than T1 group, non-linear dose–response (P non-linearity 0.017). patients, correlated (OR 5.248, 1.821–15.126, 0.002) DM group. ROC analysis revealed that had highest an AUC 0.720 0.661–0.780, < 0.001). serves as robust predictor And underscores potential clinical utility. could serve valuable tool early identification individuals at high risk.

Language: Английский

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Association between estimated glucose disposal rate and prediction of cardiovascular disease risk among individuals with cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 14, 2025

Insulin resistance is a crucial factor in the development of cardiovascular diseases (CVD), yet relationship between estimated glucose disposal rate (eGDR), an index reflecting insulin resistance, and risk new-onset CVD among individuals with cardiovascular-kidney-metabolic (CKM) syndrome stage 0–3 remains underexplored, large-scale prospective cohort studies are needed to clarify this relationship. All data for study were extracted from China Health Retirement Longitudinal Study (CHARLS). The primary outcome was incidence (including heart (HD) stroke) during follow-up period (from 2013 2020). Multivariable logistic regression models applied elucidate eGDR developing CVD. restricted cubic splines (RCS), mediation analysis, stratified analyses also employed. This included 6752 participants, whom 1495 (22%) developed Odds ratios 95% confidence intervals lowest level (<7.37 mg/kg/min) highest (≥ 11.16 1.00 (reference), 0.81 (0.68, 0.96), 0.72 (0.58, 0.88), 0.74 0.94) respectively, occurrence CVD; (0.67,0.97), (0.57,0.90), 0.75 (0.58,0.97) HD; 0.91 (0.74,1.12), 0.80 (0.62,1.04), 0.71 (0.52,0.97) stroke after adjusting all potential covariates. RCS analysis discovered approximately inverse "L" correlation HD across CKM stages (All P overall < 0.001, nonlinear = 0.005), while there negative linear (P 0.026, 0.098). Furthermore, proportions mediated through BMI 41.98%, 43.05%, 43.23% CVD, stroke, respectively. No significant interactions found. novel indicator 0–3, serving as partial mediator association risk. Addressing may represent viable strategy reducing population.

Language: Английский

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Association Between Triglyceride-Glucose Index and Hypertension: A Meta-Analysis

Frontiers in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 8

Published: May 31, 2021

Background: Triglyceride-glucose (TyG) index is a recently proposed surrogate indicator of insulin resistance. Previous studies evaluating the association between TyG and hypertension risk in general adult population showed inconsistent results. We performed meta-analysis to systematically evaluate this association. Methods: Observational studies, which evaluated independent population, were identified by systematic search PubMed, Embase, Web Science, Wanfang data, Chinese National Knowledge Infrastructure databases. A random-effect model, incorporated potential intra-study heterogeneity, was used for meta-analysis. Results: Eight observational including 200,044 participants included. Results that compared with those lowest category index, subjects highest associated higher odds [adjusted ratio (RR): 1.53, 95% confidence interval (CI): 1.26–1.85, I 2 = 54%, P &lt; 0.001]. Sensitivity analysis excluding one dataset at time consistent result (adjusted RR: 1.44–1.62, all 0.001). univariate meta-regression differences sample size, mean age, male proportion, body mass study quality score among included did not have significant influence on ( values &gt; 0.10), suggesting these characteristics may be major source heterogeneity. Subgroup analyses such as design, participant ethnicity, or sex significantly affect subgroup difference &gt;0.05). Conclusions: Higher population. Large-scale prospective cohort are needed validate findings, further elucidate pathophysiological mechanisms underlying hypertension.

Language: Английский

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Premature birth, low birth weight, small for gestational age and chronic non-communicable diseases in adult life: A systematic review with meta-analysis

Early Human Development, Journal Year: 2020, Volume and Issue: 149, P. 105154 - 105154

Published: Aug. 8, 2020

Language: Английский

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Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management

Cardiovascular Diabetology, Journal Year: 2021, Volume and Issue: 20(1)

Published: Nov. 6, 2021

Abstract Type 2 diabetes is one of the most relevant risk factors for heart failure, prevalence which increasing worldwide. The aim review to highlight current perspectives pathophysiology failure as it pertains type diabetes. This summarizes proposed mechanistic bases, explaining myocardial damage induced by diabetes-related stressors and other factors, i.e., cardiomyopathy in We complex pathology individuals with diabetes, including relationship chronic kidney disease, metabolic alterations, failure. also discuss criteria used diagnosis gold standard screening tools Currently approved pharmacological therapies primary use treatment-guiding role NT-proBNP are presented. Finally, influence presence well on COVID-19 severity briefly discussed.

Language: Английский

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Hypertension Related to Obesity: Pathogenesis, Characteristics and Factors for Control

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(20), P. 12305 - 12305

Published: Oct. 14, 2022

The World Health Organization (WHO) refers to obesity as abnormal or excessive fat accumulation that presents a health risk. Obesity was first designated disease in 2012 and since then the cost burden of have witnessed worrisome increase. hypertension are closely interrelated abdominal interferes with endocrine immune systems carries greater risk for insulin resistance, diabetes, hypertension, cardiovascular disease. Many factors at interplay between hypertension. They include hemodynamic alterations, oxidative stress, renal injury, hyperinsulinemia, sleep apnea syndrome leptin-melanocortin pathway. Genetics, epigenetics, mitochondrial also play major role. measurement blood pressure obese patients requires an adapted cuff search other secondary causes is necessary higher thresholds than general population. Lifestyle modifications such diet exercise often not enough control obesity, so far, bariatric surgery constitutes most reliable method achieve weight loss. Nonetheless, emergence new agents Semaglutide Tirzepatide offers promising alternatives. Finally, several molecular pathways actively being explored, they should significantly extend treatment options available.

Language: Английский

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Metabolic Syndrome-Related Kidney Injury: A Review and Update

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: June 23, 2022

Metabolic syndrome (MetS) includes visceral obesity, hyperglycemia, dyslipidemia, and hypertension. The prevalence of MetS is 20-25%, which an important risk factor for chronic kidney disease (CKD). causes effects on renal pathophysiology, including glomerular hyperfiltration, RAAS, microalbuminuria, profibrotic factors podocyte injury. This review compares several criteria analyzes their differences. the pathogenesis CKD insulin resistance, inflammation, oxidative stress, endothelial dysfunction. intervention MetS-related damage focus this article controlling body weight, hypertension, hyperlipidemia, requiring all components to meet criteria. In addition, interventions such as endoplasmic reticulum gut microbiota, metabolism, appetite inhibition, apoptosis, mesenchymal stem cells are reviewed.

Language: Английский

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