"When," "Where," and "How" of SARS-CoV-2 Infection Affects the Human Cardiovascular System: A Narrative Review

Balkan Medical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 7 - 22

Published: Jan. 3, 2024

Heartfailure, ischemic myocardial injuries, microvascular disease, Kounis syndrome, prolonged COVID, fibrosis, myocarditis, new-onset hypertension, pericarditis, postural orthostatic tachycardia pulmonary stroke, Takotsubo venous thromboembolism, and thrombocytopenia.In this narrative review, we describe elucidate when, where, how COVID-19 affects the human cardiovascular system in various parts of body that are vulnerable every patient category, including children athletes.

Language: Английский

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Elevated Arterial Blood Pressure as a Delayed Complication Following COVID-19—A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1837 - 1837

Published: Feb. 2, 2024

Arterial hypertension is one of the most common and significant cardiovascular risk factors. There are many well-known identified factors for its development. In recent times, there has been growing concern about potential impact COVID-19 on system relation to arterial hypertension. Various theories have developed that suggest a connection between elevated blood pressure. However, precise link SARS-CoV-2 infection long-term developing remains insufficiently explored. Therefore, primary objective our study was investigate influence pressure elevation subsequent over an extended period. To accomplish this, we conducted thorough search review relevant papers in PubMed SCOPUS databases up 3 September 2023. Our analysis encompassed total 30 eligible articles. Out reviewed, 19 them provided substantial evidence showing heightened following infection. Eight studies showed values increased after infection, while three qualified did not report any notable levels. The mechanism behind development unclear, but it suggested endothelial injury dysfunction renin-angiotensin-aldosterone may be contributory. Additionally, changes could linked lifestyle alterations often occur alongside illness. findings emphasize pressing requirement research into relationship These insights essential effective prevention management approaches individuals who experienced

Language: Английский

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High prevalence of cardiac post-acute sequelae in patients recovered from Covid-19. Results from the ARCA post-COVID study

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2024, Volume and Issue: 21, P. 200267 - 200267

Published: April 5, 2024

Many data were published about Long-Covid prevalence, very few the findings of new cardiac alterations (NCA) in COVID-19-recovered people.

Language: Английский

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Cardiovascular Considerations in the Management of People With Suspected Long COVID

Canadian Journal of Cardiology, Journal Year: 2023, Volume and Issue: 39(6), P. 741 - 753

Published: April 6, 2023

Language: Английский

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Effects of 4‐month treatment with glycocalyx dietary supplement on endothelial glycocalyx and vascular function after COVID‐19 infection

European Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Background Coronavirus disease 2019 ( COVID ‐19) has been associated with impaired endothelial and vascular function. We investigated whether intervention glycocalyx dietary supplement GDS ), containing glucosamine sulfate fucoidan, improves function after ‐19 infection. Methods Fifty‐seven convalescent patients 14 days mild‐to‐moderate infection managed in an outpatient setting were randomized to receive n = 29) or placebo 28) for 4 consecutive months. measured at baseline months: (a) perfused boundary region PBR ) of the sublingual microvessels a diameter range 4–25 μm, as marker integrity, (b) pulse wave velocity augmentation index, (c) coronary flow reserve using Doppler echocardiography, (d) malondialdehyde protein carbonyls oxidative stress markers. Results Four months treatment, who received showed greater reduction μm (−6.8% vs. −1.3%), (−13.2% −3%), index (−28.5% −2.5%), (−26% −2.9%), (−31.3% −1%) increase (12.9% 1.6%) compared p < .05). In group, was corresponding decrease r .31, .047), malondialdehyde, carbonyls, well −.59, .008) follow‐up. Post‐treatment, none under reported post‐ symptoms 21.4% placebo. Conclusion Four‐month treatment may improve Clinical Trial Registration URL: https://www.clinicaltrials.gov . Unique identifier: NCT05185934.

Language: Английский

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The role of cyclic adenosine monophosphate (cAMP) in pathophysiology of fibrosis

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104368 - 104368

Published: May 1, 2025

Language: Английский

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Impact of COVID-19 and Non-COVID-19 Hospitalized Pneumonia on Longer-Term Cardiovascular Mortality in People With Type 2 Diabetes: A Nationwide Prospective Cohort Study From Scotland

Diabetes Care, Journal Year: 2024, Volume and Issue: 47(8), P. 1342 - 1349

Published: June 18, 2024

In this study we examine whether hospitalized coronavirus disease 2019 (COVID-19) pneumonia increases long-term cardiovascular mortality more than other pneumonias in people with type 2 diabetes and aim to quantify the relative (CVD) risks associated COVID-19 versus non-COVID-19 pneumonia.

Language: Английский

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Baseline socioeconomic status predicting post-COVID-19 symptoms: Results from Isfahan COVID Cohort (ICC) study

Preventive Medicine Reports, Journal Year: 2024, Volume and Issue: 45, P. 102814 - 102814

Published: July 7, 2024

Patients experience complications following their recovery from COVID-19, known as post-COVID-19. This study aimed to investigate the association between baseline socioeconomic status (SES) and post-COVID-19 symptoms among hospitalized non-hospitalized patients. In study, we used data Isfahan COVID Cohort (ICC) a 5-year longitudinal cohort started March 10, 2020. SES was measured using short form of questionnaire (SES-SQ), consisting employment status, house room number, number trips taken, notebooks, laptop, or tablet in house. Cox proportional hazard analysis examine including general, cardiovascular respiratory systems, adjusting for potential confounders. Out 3912 patients included 66.4 % reported symptoms. There an low increased risk whole population (HR = 1.15; 95 CI, 1.01–1.31, p 0.039). Considering hospitalization revealed that with had higher experiencing 1.96; 1.23–3.12, 0.004), while non-hospitalized, lower observed 0.82; 0.70–0.97, 0.017). No significant found other general We concluded Low associated patients, it risk.

Language: Английский

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Spike Protein of SARS-CoV-2 Activates Cardiac Fibrogenesis through NLRP3 Inflammasomes and NF-κB Signaling

Cells, Journal Year: 2024, Volume and Issue: 13(16), P. 1331 - 1331

Published: Aug. 11, 2024

Background: The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to viral entry and can cause cardiac injuries. Toll-like receptor 4 (TLR4) NOD-, LPR-, pyrin-domain-containing 3 (NLRP3) inflammasome are critical immune system components implicated in fibrosis. activates NLRP3 through TLR4 or angiotensin-converting enzyme (ACE2) receptors, damaging various organs. However, the role fibrosis humans, as well its interactions with inflammasomes TLR4, remain poorly understood. Methods: We utilized scratch assays, Western blotting, immunofluorescence evaluate migration, signaling, mitochondrial calcium levels, reactive oxygen species (ROS) production, cell morphology cultured human fibroblasts (CFs) treated (S1) for 24 h without an anti-ACE2 neutralizing antibody, a blocker, inhibitor. Results: S1 enhanced CFs migration expressions collagen 1, α-smooth muscle actin, transforming growth factor β1 (TGF-β1), phosphorylated SMAD2/3, interleukin 1β (IL-1β), nuclear kappa-light-chain-enhancer activated B cells (NF-κB). increased ROS production but did not affect content morphology. Treatment antibody attenuated effects on 1 TGF-β1 expressions. Moreover, (MCC950) NF-kB inhibitors, inhibitor TAK-242, prevented protein-enhanced overexpression TGF-β1, IL-1β. Conclusion: by priming NF-κB signaling ACE2-dependent manner.

Language: Английский

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Long-term sequelae of coronavirus disease: long COVID-19 and cardiovascular outcomes (a literature review)

Zaporozhye Medical Journal, Journal Year: 2024, Volume and Issue: 26(3), P. 223 - 233

Published: May 31, 2024

The COVID-19 pandemic has serious global implications for the healthcare system and economy. Although recovery rate increased significantly morbidity decreased, long-term consequences, particularly cardiovascular, have come to fore become a problem. As result, in 2021, at WHO level, concept of “long-term COVID” was introduced, including more than 100 already described symptoms patients least 3 months after initial recovery. At same time, clinical are not specific, strategies treatment such disorders been worked out, measures detect and/or prevent development these complications organized. aim: summarize available data modern views on cardiovascular effects COVID-19, reveal probable causes risk factors their development, as well analyze presented information pathogenetic mechanisms consequences coronavirus disease. literature analysis shown that SARS-CoV-2 viral persistence human body, reactivation other agents, immune dysregulation, autoimmunization occurrence microvascular thrombosis endothelial dysfunction among long COVID. all findings represent theoretical concepts regarding pathogenesis disease, complementing interacting with each other, moment, there is no formulated uniform explanation COVID-19. Also, large-scale studies point need special attention Among those myocarditis, pericarditis, heart failure, arterial hypertension, arrhythmias, pulmonary embolism, cerebrovascular disorders, cardiomyopathy. Given prevalence diseases impact mortality, processes threat context pandemic. Conclusions. COVID analyzed, COVID-related from acute disease examined detail. study this issue extremely important since only by understanding association between diseases, studying identifying factors, it possible improve prevention take control over level.

Language: Английский

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