Cell death shapes cancer immunity: spotlighting PANoptosis DOI Creative Commons
Lixia Gao, Chloe Shay, Yong Teng

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: June 15, 2024

Abstract PANoptosis represents a novel type of programmed cell death (PCD) with distinctive features that incorporate elements pyroptosis, apoptosis, and necroptosis. is governed by newly discovered cytoplasmic multimeric protein complex known as the PANoptosome. Unlike each these PCD types individually, still in early stages research warrants further exploration its specific regulatory mechanisms primary targets. In this review, we provide brief overview conceptual framework molecular components PANoptosis. addition, highlight recent advances understanding therapeutic applications By elucidating crosstalk between apoptosis necroptosis summarizing functional consequences special focus on tumor immune microenvironment, review aims to theoretical basis for potential application cancer therapy.

Language: Английский

Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment DOI Creative Commons
Peng Zhu,

Zhuo-Ran Ke,

Jing-Xian Chen

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 9, 2023

PANoptosis, a new research hotspot at the moment, is cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur same population. In essence, PANoptosis highly coordinated dynamically balanced programmed inflammatory pathway that combines main features of necroptosis. Many variables, such as infection, injury, or self-defect, may be involved occurrence with assembly activation PANoptosome being most critical. has been linked to development multiple systemic diseases human body, including infectious diseases, cancer, neurodegenerative diseases. Therefore, it necessary clarify process occurrence, regulatory mechanism its relation this paper, we summarized differences relations between three types death, emphatically expounded molecular patterns expectation facilitating application regulation disease treatment.

Language: Английский

Citations

103
PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis DOI Creative Commons
Chunxia Shi, Pan Cao, Yukun Wang

et al.

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 1523 - 1532

Published: April 1, 2023

Abstract: PANoptosis is a new cell death proposed by Malireddi et al in 2019, which characterized pyroptosis, apoptosis and necroptosis, but cannot be explained any of them alone. The interaction between necroptosis involved PANoptosis. In this review, from the perspective PANoptosis, we focus on relationship key molecules process formation PANoptosome, as well role diseases. We aim to understand mechanism provide basis for targeted intervention PANoptosis-related treat human Keywords: apoptosis,

Language: Английский

Citations

75
PANoptosis: Mechanisms, biology, and role in disease DOI Open Access

Xu Sun,

Yanpeng Yang,

Xiaona Meng

et al.

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 246 - 262

Published: Oct. 12, 2023

Summary Cell death can be executed through distinct subroutines. PANoptosis is a unique inflammatory cell modality involving the interactions between pyroptosis, apoptosis, and necroptosis, which mediated by multifaceted PANoptosome complexes assembled via integrating components from other modalities. There growing interest in process function of PANoptosis. Accumulating evidence suggests that occurs under diverse stimuli, for example, viral or bacterial infection, cytokine storm, cancer. Given impact across disease spectrum, this review briefly describes relationships highlights key molecules formation activation, outlines roles diseases together with potential therapeutic targeting. We also discuss important concepts pressing issues future research. Improved understanding its mechanisms crucial identifying novel targets strategies.

Language: Английский

Citations

69
Application of artificial intelligence for improving early detection and prediction of therapeutic outcomes for gastric cancer in the era of precision oncology DOI
Zhe Wang, Yang Liu, Xing Niu

et al.

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 93, P. 83 - 96

Published: April 27, 2023

Language: Английский

Citations

45
Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases DOI Creative Commons

Lian Wang,

Yanghui Zhu,

Lu Zhang

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(12)

Published: Dec. 21, 2023

Abstract Pyroptosis, apoptosis, and necroptosis are mainly programmed cell death (PCD) pathways for host defense homeostasis. PANoptosis is a newly distinct inflammatory PCD pathway that uniquely regulated by multifaceted PANoptosome complexes highlights significant crosstalk coordination among pyroptosis (P), apoptosis (A), and/or necroptosis(N). Although some studies have focused on the possible role of PANpoptosis in diseases, pathogenesis complex underestimated. Furthermore, progress related agonists or inhibitors disorders has not yet been thoroughly discussed. In this perspective, we provide perspectives context diverse pathological conditions human diseases. The treatment targeting also summarized. conclusion, involved plenty including but limited to microbial infections, cancers, acute lung injury/acute respiratory distress syndrome (ALI/ARDS), ischemia-reperfusion, organic failure. seems be double-edged sword conditions, as induces negative impact prognosis like COVID-19 ALI/ARDS, while provides protection from HSV1 Francisella novicida infection, kills cancer cells suppresses tumor growth colorectal cancer, adrenocortical carcinoma, other cancers. Compounds endogenous molecules promising therapeutic strategies, which can act PANoptosomes-associated members regulate PANoptosis. More researches needed better understand pathology develop treatment.

Language: Английский

Citations

43
PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment DOI Creative Commons
Jie Gao,

Anying Xiong,

Jiliu Liu

et al.

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(7), P. 970 - 983

Published: March 29, 2024

Abstract This comprehensive review explores the intricate mechanisms of PANoptosis and its implications in cancer. PANoptosis, a convergence apoptosis, pyroptosis, necroptosis, plays crucial role cell death immune response regulation. The study delves into molecular pathways each mechanism their crosstalk within emphasizing shared components like caspases PANoptosome complex. It highlights significant various cancers, including respiratory, digestive, genitourinary, gliomas, breast showing impact on tumorigenesis patient survival rates. We further discuss interwoven relationship between tumor microenvironment (TME), illustrating how influences behavior progression. underscores dynamic interplay tumors microenvironments, focusing roles different cells interactions with cancer cells. Moreover, presents new breakthroughs therapy, potential targeting to enhance anti-tumor immunity. outlines strategies manipulate for therapeutic purposes, such as key signaling molecules caspases, NLRP3, RIPK1, RIPK3. novel treatments immunogenic PANoptosis-initiated therapies nanoparticle-based is also explored.

Language: Английский

Citations

33
Different types of cell death in diabetic endothelial dysfunction DOI Open Access
Jieru Shen,

Wenqing San,

Yangyang Zheng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115802 - 115802

Published: Oct. 31, 2023

Diabetes mellitus is a metabolic disease caused by disorders of insulin secretion and utilization. Long-term hyperglycemia, resistance, glucose lipid metabolism cause vascular endothelial cell damage. Endothelial dysfunction key feature diabetic complications such as nephropathy, retinopathy, neuropathy, atherosclerosis. Importantly, death thought to be factor contributing injury. Morphologically, can divided into three forms: type I apoptosis, II autophagy, III necrosis. According the difference in function, accidental (ACD) regulated (RCD). RCD controlled process involving numerous proteins precise signaling cascades. Multiple subroutines covered may involved dysfunction, including necroptosis, pyroptosis, entosis, ferroptosis, ferroautophagy, parthanatos, netotic death, lysosome-dependent alkaliptosis, oxeiptosis, cuproptosis, PANoptosis. This article briefly reviews mechanism significance associated with which will help deepen understanding provide new therapeutic ideas.

Language: Английский

Citations

37
Current evidence and therapeutic implication of PANoptosis in cancer DOI Creative Commons
Dickson Kofi Wiredu Ocansey, Fei Qian,

Peipei Cai

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 14(2), P. 640 - 661

Published: Dec. 26, 2023

Regulated cell death (RCD) is considered a critical pathway in cancer therapy, contributing to eliminating cells and influencing treatment outcomes. The application of RCD marked by its potential targeted therapy immunotherapy. As type RCD, PANoptosis has emerged as unique form programmed (PCD) characterized features pyroptosis, apoptosis, necroptosis but cannot be fully explained any these pathways alone. It regulated multi-protein complex called the PANoptosome. relatively new concept first described 2019, been shown play role many diseases, including cancer, infection, inflammation. This study reviews PCD particularly emergence implication developing therapeutic strategies for cancer. Studies have that characterization patterns can predict survival response immunotherapy chemotherapy, highlighting used target treatment. also plays limiting spread cells. allows elimination multiple address various challenges treatment, drug resistance immune evasion. Moreover, active investigation mechanisms agents induce likely yield effective treatments improve patient Research on still ongoing, it rapidly evolving field with lead

Language: Английский

Citations

33
PANoptosis-based molecular subtyping and HPAN-index predicts therapeutic response and survival in hepatocellular carcinoma DOI Creative Commons
Fei Song, Chenggui Wang,

Jiazhen Mao

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 15, 2023

Hepatocellular carcinoma (HCC) is a highly prevalent and fatal cancer. The role of PANoptosis, novel form programmed cell death, in HCC yet to be fully understood. This study focuses on identifying analyzing PANoptosis-associated differentially expressed genes (HPAN_DEGs), aiming enhance our understanding pathogenesis potential treatment strategies.We analyzed from TCGA IGCG databases mapped them the PANoptosis gene set, 69 HPAN_DEGs. These underwent enrichment analyses, consensus clustering analysis was used determine three distinct subgroups based their expression profiles. immune characteristics mutation landscape these were evaluated, drug sensitivity predicted using HPAN-index relevant databases.The HPAN_DEGs mainly enriched pathways associated with cycle, DNA damage, Drug metabolism, Cytokines, Immune receptors. We identified subtypes (Cluster_1, SFN+PDK4-; Cluster_2, SFN-PDK4+; Cluster_3, SFN/PDK4 intermediate expression) profiles exhibited clinical outcomes, characteristics, landscapes. HPAN-index, generated by machine learning levels HPAN_DEGs, as an independent prognostic factor for HCC. Moreover, high group response immunotherapy, while low showed small molecule targeted drugs. Notably, we observed that YWHAB plays significant Sorafenib resistance.This crucial tumor growth, infiltration, resistance Additionally, discovered constructed predict immunotherapeutic sensitivity. Our findings underscore resistance, presenting valuable insights personalized therapeutic strategy development

Language: Английский

Citations

28
PANoptosis: Emerging mechanisms and disease implications DOI

Zehong Qi,

Lili Zhu, Kangkai Wang

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 333, P. 122158 - 122158

Published: Oct. 6, 2023

Language: Английский

Citations

26