Oncology Letters,
Journal Year:
2024,
Volume and Issue:
28(4)
Published: Aug. 5, 2024
Treatment
modalities
involving
an
immune-checkpoint-inhibitor
(ICI)
have
emerged
as
therapeutic
options
in
advanced
hepatocellular
carcinoma
(HCC).
Nonetheless,
auxiliary
biomarkers
are
required
to
evaluate
their
efficacy.
The
present
study
aimed
assess
the
potential
of
blood
mucosa-associated
lymphoid
tissue
1
(MALT1)
reflecting
clinical
response
and
prognosis
patients
with
HCC
who
received
ICI
therapy.
Peripheral
was
collected
from
51
were
about
receive
or
ICI-based
treatment.
Blood
MALT1
levels
determined
using
reverse
transcription-quantitative
PCR,
50
healthy
controls
(HCs)
also
assessed.
Besides,
treatment
survival
data
collected.
Wilcoxon
rank-sum
test
used
for
comparison
analysis
Spearman's
rank
correlation
coefficient
analysis.
prognostic
value
by
Kaplan-Meier
curve
log-rank
test.
Univariate
multivariate
Cox
regression
models
identify
factors
associated
progression-free
(PFS)
overall
(OS).
results
demonstrated
that
significantly
increased
compared
HCs
(P<0.001).
portal
vein
invasion
(vs.
without
invasion;
P=0.010),
extrahepatic
disease
disease;
P=0.026)
α-fetoprotein
(AFP)
≥200
ng/ml
AFP
<200
ng/ml;
P=0.040).
After
4
cycles
therapy,
objective
rate
(ORR)
control
(DCR)
29.4
68.6%,
respectively.
negatively
ORR
(P=0.043)
DCR
(P=0.004).
Furthermore,
PFS
OS
shortened
high
(cut-off
median)
those
low
levels.
adjusting
models,
be
a
significant
independent
risk
factor
[hazard
ratio
(HR)=2.419;
P=0.009]
(HR=2.706,
P=0.018)
In
summary,
serve
biomarker
reflect
Phytomedicine,
Journal Year:
2024,
Volume and Issue:
129, P. 155600 - 155600
Published: April 7, 2024
Breast
cancer
stands
as
the
most
common
malignancy
among
women
globally
and
a
leading
cause
of
cancer-related
mortality.
Conventional
treatments,
such
surgery,
hormone
therapy,
radiotherapy,
chemotherapy,
small-molecule
targeted
often
fall
short
addressing
complexity
heterogeneity
certain
breast
subtypes,
to
drug
resistance
metastatic
progression.
Thus,
search
for
novel
therapeutic
targets
agents
is
imperative.
Given
their
low
toxicity
abundant
variety,
natural
products
derivatives
are
increasingly
considered
valuable
sources
anticancer
drugs.
This
review
aims
elucidate
pharmacological
impacts
underlying
mechanisms
active
compounds
found
in
select
derivatives,
primarily
focusing
on
treatment.
It
intends
underscore
potential
these
substances
combating
guide
future
research
directions
development
product-based
therapeutics.
We
conducted
comprehensive
searches
electronic
databases
PubMed,
Web
Science,
Scopus
until
October
2023,
using
keywords
'breast
cancer',
'natural
products',
'derivatives',
'mechanism',
'signaling
pathways',
various
keyword
combinations.
The
presents
spectrum
phytochemicals,
including
but
not
limited
flavonoids,
polyphenols,
alkaloids,
examines
actions
animal
cellular
models
cancer.
effects
manifested
through
diverse
mechanisms,
induction
cell
death
via
apoptosis
autophagy,
suppression
tumor
angiogenesis.
An
increasing
array
proving
effective
against
Future
strategies
can
benefit
from
strategic
enhancement
properties
compounds,
optimization
action,
improved
bioavailability,
minimized
side
effects.
forthcoming
should
prioritize
facets
maximize
Vaccines,
Journal Year:
2025,
Volume and Issue:
13(4), P. 337 - 337
Published: March 21, 2025
Dendritic
cells
(DCs)
act
as
a
bridge
between
innate
and
adaptive
immunity
by
presenting
antigens
to
effector
immune
have
shown
broad
application
potential
in
tumor
immunotherapy.
However,
the
clinical
translation
of
DC
vaccines
encounters
significant
challenges,
such
immunosuppressive
microenvironment
(TME)
sub-optimal
function
vaccine
efficacy
vivo.
In
this
review,
our
investigation
has
uncovered
latest
developments
their
cancer
immunotherapy,
with
special
emphasis
on
integration
nanotechnology.
Several
types
nanomaterials,
including
protein
cage
nanoparticles
(NPs),
biomimetic
NPs,
targeted
multifunctional
been
developed
enhance
antigen
presentation
ability
DCs
stimulatory
effects
T
cells.
addition,
we
also
summarized
synergistic
anti-cancer
checkpoint
inhibitors,
chemotherapy,
radiotherapy.
recent
advances
nanotechnology
made
it
possible
develop
novel
biomarkers
that
can
capacity
stimulate
These
not
only
improve
accuracy
precision
design
but
provide
new
insights
into
understanding
mechanisms
DC-mediated
response.
Despite
challenges
pertaining
technical
complexities
individual
adaptation
production
vaccines,
personalized
immunotherapy
based
is
expected
become
an
important
part
treatment
rapid
biotechnology
immunology.
This
review
provides
perspectives
solutions
for
optimal
therapy.
Cancer Cell International,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: Sept. 13, 2023
Abstract
A
growing
body
of
evidence
indicates
that
the
anticancer
effect
immune
system
can
be
activated
by
immunogenic
modulation
dying
cancer
cells.
Cancer
cell
death,
as
a
result
activation
an
immunomodulatory
response,
is
called
death
(ICD).
This
regulated
occurs
because
increased
immunogenicity
cells
undergoing
ICD.
ICD
plays
crucial
role
in
stimulating
activity
therapy.
therefore
innovative
route
to
improve
responses
associated
with
releasing
damage-associated
molecular
patterns
(DAMPs).
Several
conventional
and
chemotherapeutics,
well
preclinically
investigated
compounds
from
natural
sources,
possess
immunostimulatory
properties
induction.
Natural
have
gained
much
interest
therapy
owing
their
low
toxicity,
cost,
inhibiting
interfering
different
mechanisms,
which
are
critical
progression.
Therefore,
identifying
ICD-inducing
potency
presents
agents
promising
potential
immunotherapy.
Naturally
derived
believed
act
immunoadjuvants
they
elicit
stress
DAMPs.
Acute
exposure
DAMP
molecules
activate
antigen-presenting
(APCs),
such
dendritic
(DCs),
leads
downstream
events
cytotoxic
T
lymphocytes
(CTLs)
killer
(NKs).
inducers
may
interesting
approach
induction;
however,
parameters
determine
whether
compound
used
inducer
should
elucidated.
Here,
we
aimed
discuss
impact
multiple
inducers,
mainly
focusing
on
agents,
including
plant-derived,
marine
molecules,
bacterial-based
compounds,
release
corresponding
signaling
cascades
triggering
responses.
In
addition,
synthetic
for
also
discussed.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
204, P. 107203 - 107203
Published: May 6, 2024
Recent
research
has
demonstrated
the
immunomodulatory
potential
of
Panax
notoginseng
in
treatment
chronic
inflammatory
diseases
and
cerebral
hemorrhage,
suggesting
its
significance
clinical
practice.
Nevertheless,
complex
immune
activity
various
components
hindered
a
comprehensive
understanding
immune-regulating
properties
notoginseng,
impeding
broader
utilization.
This
review
evaluates
effect
to
types
white
blood
cells,
elucidates
underlying
mechanisms,
compares
effects
different
active
fractions,
aiming
provide
theory
basis
for
future
investigation.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 117049 - 117049
Published: June 29, 2024
Ginseng,
the
dried
root
of
Panax
ginseng
C.A.
Mey.,
is
widely
used
in
Chinese
herbal
medicine.
Ginsenosides,
primary
active
components
ginseng,
exhibit
diverse
anticancer
functions
through
various
mechanisms,
such
as
inhibiting
tumor
cell
proliferation,
promoting
apoptosis,
and
suppressing
invasion
migration.
In
this
article,
mechanism
action
20
ginsenoside
subtypes
therapy
research
progress
multifunctional
nanosystems
are
reviewed,
order
to
provide
reference
for
clinical
prevention
treatment
cancer.
Applied Biological Chemistry,
Journal Year:
2024,
Volume and Issue:
67(1)
Published: March 6, 2024
Abstract
Immune
disorders
have
become
one
of
the
public
health
problems
and
imposes
a
serious
economic
social
burden
worldwide.
Ginsenosides,
main
active
constituents
ginseng,
are
regarded
as
novel
supplementary
strategy
for
preventing
improving
immune
related
diseases.
This
review
summarized
recent
research
progress
ginsenosides
in
immunomodulation
proposed
future
directions
to
promote
development
application
ginsenosides.
After
critically
reviewing
immunomodulatory
potential
both
vitro
vivo
even
clinical
data
humans,
we
provided
perspective
that
regulated
system
through
activation
cells,
cytokines,
signaling
pathways
such
MAPK,
PI3K/Akt,
STAT,
AMPK,
well
positively
affected
organs,
gut
flora
structure,
systemic
inflammatory
responses.
However,
evidence
safety
efficacy
is
insufficient,
remain
incompletely
characterized.
We
believe
this
will
provide
valuable
reference
further
on
dietary
supplements
with
effects.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: June 18, 2024
Malignant
tumors
are
complex
systemic
chronic
diseases
and
one
of
the
major
causes
human
mortality.
Targeted
therapy,
chemotherapy,
immunotherapy,
radiotherapy
examples
mainstream
allopathic
medicine
treatments
that
effective
for
intermediate
advanced
malignant
tumors.
The
ongoing
use
conventional
has
resulted
in
adverse
responses
drug
resistance,
which
have
hampered
its
efficacy.
As
an
important
component
complementary
alternative
medicine,
Chinese
been
found
to
antitumor
effects
played
role
enhancing
therapeutic
sensitivity
reducing
incidence
events
improving
immune-related
functions.
combined
application
adjuvant
begun
gain
acceptance
is
gradually
used
field
therapy.
Traditional
natural
medicines
their
active
ingredients,
as
well
patent
medicines,
proven
excellent
efficacy
good
safety
treatment
various
This
paper
focuses
on
mechanism
action
research
progress
combining
above
drugs
with
increase
sensitivity,
alleviate
reduce
reactions,
improve
body’s
immune
function.
To
encourage
clinical
development
herb
therapy
provide
ideas
information
creating
safer
more
anticancer
medication
combinations,
significant
functions
therapies
cancer
described
detail.
