Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures – 2019 update: cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic & Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists

Surgery for Obesity and Related Diseases, Journal Year: 2019, Volume and Issue: 16(2), P. 175 - 247

Published: Nov. 3, 2019

Language: Английский

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Clinical Practice Guidelines For The Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures – 2019 Update: Cosponsored By American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society For Metabolic & Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists

Endocrine Practice, Journal Year: 2019, Volume and Issue: 25, P. 1 - 75

Published: Nov. 4, 2019

Language: Английский

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The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 11

Published: June 9, 2020

The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), shunts carbons back to the glycolytic or gluconeogenic pathway. PPP has been demonstrated be a major regulator for cellular reduction-oxidation (redox) homeostasis biosynthesis. Enzymes in are reported play important roles many human diseases. In this review, we will discuss role of type 2 diabetes cancer.

Language: Английский

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Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures – 2019 Update: Cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic and Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists

Obesity, Journal Year: 2020, Volume and Issue: 28(4)

Published: March 23, 2020

Objective The development of these updated clinical practice guidelines (CPGs) was commissioned by the American Association Clinical Endocrinologists (AACE), Obesity Society (TOS), for Metabolic and Bariatric Surgery (ASMBS), Medicine (OMA), Anesthesiologists (ASA) Boards Directors in adherence with AACE 2017 protocol standardized production CPGs, algorithms, checklists. Methods Each recommendation evaluated based on new evidence from 2013 to present subjective factors provided experts. Results New or topics this CPG include: contextualization an adiposity‐based chronic disease complications‐centric model, nuance‐based algorithm/checklist‐assisted decision‐making about procedure selection, novel bariatric procedures, enhanced recovery after surgery protocols, logistical concerns (including cost factors) current health care arena. There are 85 numbered recommendations that have supporting evidence, which 61 revised 12 new. Noting there can be multiple statements within a single recommendation, 31 (13%) Grade A, 42 (17%) B, 72 (29%) C, 101 (41%) D recommendations. 858 citations, 81 (9.4%) level (EL) 1 (highest), 562 (65.5%) EL 2, (8.4%) 3, 143 (16.7%) 4 (lowest). Conclusions procedures remain safe effective intervention higher‐risk patients obesity. should context disease. A team approach perioperative is mandatory, special attention nutritional metabolic issues.

Language: Английский

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Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 320 - 320

Published: Jan. 22, 2021

Magnesium (Mg2+) deficiency is probably the most underestimated electrolyte imbalance in Western countries. It frequent obese patients, subjects with type-2 diabetes and metabolic syndrome, both adulthood childhood. This narrative review aims to offer insights into pathophysiological mechanisms linking Mg2+ obesity risk of developing syndrome type 2 diabetes. Literature highlights critical issues about treatment deficiency, such as lack a clear definition nutritional status, use different salts dosage duration supplementation. Despite agreement, an appropriate dietary pattern, including right intake Mg2+, improves by reducing blood pressure, hyperglycemia, hypertriglyceridemia. occurs through modulation gene expression proteomic profile well positive influence on composition intestinal microbiota metabolism vitamins B1 D.

Language: Английский

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Malnutrition in Obesity: Is It Possible?

Obesity Facts, Journal Year: 2021, Volume and Issue: 15(1), P. 19 - 25

Published: Nov. 8, 2021

The World Health Organization (WHO) classifies malnutrition as the biggest threat to public health worldwide, and this condition is observed in 20-60% of hospitalized patients. Malnutrition a state body which due insufficient supply or incorrect absorption essential nutrients, composition changes body's functions are impaired. associated not only with reduced mass index but also obesity.

Language: Английский

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Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(4), P. 548 - 560.e7

Published: Oct. 1, 2020

Language: Английский

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The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat

Mitochondrion, Journal Year: 2023, Volume and Issue: 70, P. 59 - 102

Published: March 1, 2023

Language: Английский

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Dietary supplementation with probiotics promotes weight loss by reshaping the gut microbiome and energy metabolism in obese dogs

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(3)

Published: Jan. 25, 2024

ABSTRACT Obesity and overweight among companion animals are significant concerns, paralleling the issues observed in human populations. Recent research has highlighted potential benefits of various probiotics addressing weight-related changes, obesity, associated pathologies. In this study, we delved into beneficial probiotic mechanisms high-fat-induced obese canines, revealing that Enterococcus faecium IDCC 2102 (IDCC 2102) Bifidobacterium lactis 4301 4301) have capacity to mitigate increase body weight lipid accumulation canines subjected a high-fat diet hyperlipidemic Caenorhabditis elegans ( C. ) strain VS29. Both demonstrated ability reduce systemic inflammation hormonal disruptions induced by obesity. Notably, these modifications microbiota promoting lactic acid bacteria, including Lactobacillaceae , Ruminococcaceae S24-7 with concomitant activation pyruvate metabolism. 4301, through generation bacterial short-chain fatty acids carboxylic acids, facilitated glycolysis contributed ATP synthesis. Meanwhile, produced metabolites such as acetic butyric acid, exhibiting particular stimulate dopamine synthesis canine model. This stimulation led restoration eating behavior improvements glucose insulin tolerance. summary, propose novel for treatment based on 4301. These enhanced energy utilization response high caloric intake, thereby preventing restoring stability fecal microbiota. Consequently, intervention resulted reduction caused diet. IMPORTANCE Probiotic supplementation affected commensal proliferation, administering increased activated metabolism body, which is related propanate result boosting production via specialized pathways, hence contributing activity.

Language: Английский

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Thiamine deficiency aggravates experimental colitis in mice by promoting glycolytic reprogramming in macrophages

British Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Inflammatory bowel disease (IBD) is closely associated with immune dysfunction, where nutrient-mediated metabolic flux dictates cell fate and function. Thiamine a central water-soluble vitamin involved in cellular energy metabolism, its deficiency has been reported IBD patients. However, whether thiamine cause or consequence of pathogenesis remains unclear. The current study aimed to reveal the immunometabolic regulation macrophages underlying mechanism colitis development. was induced C57BL/6 mice bone marrow-derived (BMDMs), by administering thiamine-deficient diet/medium together pyrithiamine hydrobromide. frequency macrophage phenotypes their intracellular metabolism were detected using flow cytometry non-targeted metabolomics, respectively. aggravated ulcerative promoted infiltration proinflammatory M1 colonic lamina propria. Our mechanistic revealed that impaired pyruvate dehydrogenase (PDH) activity, thereby reprogramming glucose enhance glycolysis lactic acid accumulation macrophages. Using well-established PDH inhibitor (CPI-613) (galloflavin), we further demonstrated inhibition mimics, while lactate partially rescues, deficiency-induced experimental mice. provides evidence linking activation aggravation, suggesting monitoring status adjusting intake necessary protect against colitis.

Language: Английский

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