Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

Nutrients, Journal Year: 2021, Volume and Issue: 13(10), P. 3603 - 3603

Published: Oct. 14, 2021

Vitamin D deficiency is a prevalent condition, occurring in about 30–50% of the population, observed across all ethnicities and among age groups. Besides established role vitamin calcium homeostasis, its emerging as new risk factor for cardiovascular disease (CVD). In particular, several epidemiological clinical studies have reported close association between low levels major CVDs, such coronary artery disease, heart failure, atrial fibrillation. Moreover, these settings, seems to predispose increased morbidity, mortality, recurrent events. Despite this growing evidence, interventional trials with supplementation patients at or CVD are still controversial. review, we aimed summarize currently available evidence supporting link CVDs terms prevalence, relevance, prognostic impact, potential therapeutic implications.

Language: Английский

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Small molecules in the treatment of COVID-19

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 5, 2022

Abstract The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to societies economies. Until now, effective therapeutics against are in high demand. Along with our improved understanding the structure, function, pathogenic process SARS-CoV-2, many small molecules potential anti-COVID-19 effects have been developed. So far, several antiviral strategies were explored. Besides directly inhibition viral proteins such as RdRp M pro , interference host enzymes including ACE2 proteases, blocking relevant immunoregulatory pathways represented by JAK/STAT, BTK, NF-κB, NLRP3 pathways, regarded feasible drug development. development treat achieved strategies, computer-aided lead compound design screening, natural product discovery, repurposing, combination therapy. Several representative remdesivir paxlovid proved or authorized emergency use countries. And candidates entered clinical-trial stage. Nevertheless, due epidemiological features variability issues it is necessary continue exploring novel COVID-19. This review discusses current findings for treatment. Moreover, their detailed mechanism action, chemical structures, preclinical clinical efficacies discussed.

Language: Английский

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Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 334 - 334

Published: Jan. 9, 2023

Deficiency in vitamin D (VitD), a lipid-soluble and steroid hormone, affects approximately 24% to 40% of the population Western world. In addition its well-documented effects on musculoskeletal system, VitD also contributes importantly promotion preservation cardiovascular health via modulating immune inflammatory functions regulating cell proliferation migration, endothelial function, renin expression, extracellular matrix homeostasis. This brief overview focuses cerebrovascular cellular, molecular, functional changes that occur circulatory system deficiency (VDD). It explores links among VDD adverse vascular remodeling, dysfunction, inflammation, increased risk for diseases. Improved understanding complex role pathogenesis atherosclerotic diseases, stroke, cognitive impairment is crucial all cardiologists, dietitians, geriatricians, as presents an easy target intervention.

Language: Английский

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Relationship between life’s essential 8, vitamin D, and cardiometabolic outcomes

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: 222, P. 112057 - 112057

Published: Feb. 22, 2025

Language: Английский

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Vitamin D and Obesity/Adiposity—A Brief Overview of Recent Studies

Nutrients, Journal Year: 2022, Volume and Issue: 14(10), P. 2049 - 2049

Published: May 13, 2022

Observational studies classically find an inverse relationship between human plasma 25-hydroxyvitamin D concentration and obesity. However, interventional genetic have failed to provide clear conclusions on the causal effect of vitamin obesity/adiposity. Likewise, supplementation in obese rodents has mostly improve obesity parameters, whereas several lines evidence prospective humans point a preventive onset Recent investigating impact maternal deficiency women rodent models adipose tissue biology programming offspring further support metabolically driven sufficiency. The aim this review is summarize state knowledge obesity/adiposity metabolic trajectory offspring.

Language: Английский

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Effects of vitamin D supplementation during pregnancy on offspring health at birth: A meta-analysis of randomized controlled trails

Clinical Nutrition, Journal Year: 2022, Volume and Issue: 41(7), P. 1532 - 1540

Published: May 17, 2022

Language: Английский

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Cardio-Protective Properties and Health Benefits of Fish Lipid Bioactives; The Effects of Thermal Processing

Marine Drugs, Journal Year: 2022, Volume and Issue: 20(3), P. 187 - 187

Published: March 2, 2022

The beneficial effects of fish-derived lipid bioactives have come to prominence over the last few decades, especially for their utilization in fish oils, supplements, and nutraceuticals. Omega-3 (n-3) polyunsaturated fatty acids (PUFA), vitamins, carotenoids, polar from shown possess a vast range against multitude chronic disorders inflammation-and cardiovascular (CVD). observed cardio-protective health benefits are believed be attributed synergy these bioactives. Within present article recent findings literature on content mainly consumed species, bio-functionality, is thoroughly reviewed. Moreover, recovery valorization such by-products fishing by-catch, order reduce waste, while developing useful products containing lipids leftover materials fisheries aquaculture industries, also industrial environmental interest. Emphasis given heat treatments during processing structures bio-functionality marine bioactives, based paradigm different cooking methodologies thermal processing, compounds produced treatment(s) with detrimental changes profile, which can its efficacy, Novel green extraction technologies low temperature fishery needed undesirable sustainable environmentally friendly way.

Language: Английский

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Dietary Supplements Potentially Target Plasma Glutathione Levels to Improve Cardiometabolic Health in Patients with Diabetes Mellitus: A Systematic Review of Randomized Clinical Trials

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 944 - 944

Published: Feb. 14, 2023

Cardiovascular diseases (CVDs) continue to be the leading cause of death in people with diabetes mellitus. Severely suppressed intracellular antioxidant defenses, including low plasma glutathione (GSH) levels, are consistently linked pathological features such as oxidative stress and inflammation. In fact, it has already been established that GSH levels associated increased risk CVD diabetes. Dietary supplements widely used may offer therapeutic benefits for at an developing CVDs. However, information remains thoroughly scrutinized. Hence, current systematic review explored prominent search engines, PubMed Google Scholar, updated literature from randomized clinical trials reporting on effects dietary Available evidence indicates supplements, coenzyme Q10, selenium, curcumin, omega-3 fatty acids, vitamin E or D, potentially improve cardiometabolic health patients Such beneficial related enhancing reducing cholesterol, biomarkers available is very limited additional studies still required validate these findings, resolving issues bioavailability bioactive compounds.

Language: Английский

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Roles of vitamins and nutrition in obstructive sleep apnea

Expert Review of Respiratory Medicine, Journal Year: 2025, Volume and Issue: 19(2), P. 145 - 163

Published: Feb. 1, 2025

Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder, with a prevalence that rises alongside increasing of obesity. OSA characterized by low-inflammatory state and followed cardiovascular metabolic sequelae. Continuous positive airway pressure (CPAP) represents cornerstone treatment for severe OSA. However, poor compliance CPAP renders challenging venture. Weight loss exercise are recommended as adjunctive options Several diets have proven to facilitate weight loss, alleviate inflammatory status in patients Moreover, several vitamins exhibit antioxidant properties beneficially affect pathology reduce risk complications. This narrative review aims summarize current knowledge regarding effect nutrition vitamin deficiencies on Included were publications, relevant topic, different types design (i.e. cross-sectional studies, cohort clinical trials, systematic reviews, meta-analyses, etc.) indexed PubMed database until 31 March 2024. In addition other food components, such proteins, carbohydrates, anti-inflammatory agents, A, B, C, D, E, sodium, may play beneficial role incidence severity

Language: Английский

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Nutritional Therapy in Persons Suffering from Psoriasis

Nutrients, Journal Year: 2021, Volume and Issue: 14(1), P. 119 - 119

Published: Dec. 28, 2021

Psoriasis is a chronic inflammatory skin disease. Immunological, genetic, and environmental factors, including diet, play part in the pathogenesis of psoriasis. Metabolic syndrome or its components are frequent co-morbidities persons with A change eating habits can improve quality life patients by relieving lesions reducing risk other diseases. low-energy diet recommended for excess body weight. Persons suffering from psoriasis should limit intake saturated fatty acids replace them polyunsaturated omega-3 family, which have an anti-inflammatory effect. In therapy psoriasis, introduction antioxidants such as vitamin A, C, E, carotenoids, flavonoids, selenium extremely important. Vitamin D supplementation also recommended. Some authors suggest that alternative diets positive effect on course These include: gluten-free vegetarian Mediterranean diet. Diet be tailored to pharmacological treatment. For instance, folic acid introduced taking methotrexate. The purpose this paper discuss detail nutritional recommendations

Language: Английский

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