Microbiota in pancreatic health and disease: the next frontier in microbiome research

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2019, Volume and Issue: 17(1), P. 53 - 64

Published: Dec. 6, 2019

Language: Английский

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How uterine microbiota might be responsible for a receptive, fertile endometrium

Human Reproduction Update, Journal Year: 2018, Volume and Issue: 24(4), P. 393 - 415

Published: March 28, 2018

Fertility depends on a receptive state of the endometrium, influenced by hormonal and anatomical adaptations, as well immune system. Local systemic immunity is greatly microbiota. Recent discoveries 16S rRNA in endometrium ability to detect low-biomass microbiota fueled notion that uterus may be indeed non-sterile compartment. To date, concept 'sterile womb' focuses utero effects offspring neonatal immunity. However, little awareness has been raised regarding importance uterine for endometrial physiology reproductive health; manifested fertility placentation.Commensal colonization widely discussed literature. The objective this review outline possible healthy, fertile uterus. We present available evidence microbiota, focusing recent findings based rRNA, depict endometrium. highlight role host tissue adaptation, conferring protection against pathogens. Based knowledge interaction mucosal cells gut with local microbiome, we want investigate potential implications commensal health.PubMed Google Scholar were searched articles English indexed from 1 January 2008 March 2018 '16S rRNA', 'uterus' related search terms assess microbiome analysis. A manual references within resulting was performed. functional contributions health, studies other body sites additionally assessed.Challenging view sterile its infancy and, no conclusions 'core microbiome' can drawn. Nevertheless, certain and/or associated compounds accumulates. presence or their constituent molecules, such polysaccharide Bacteroides fragilis capsule, go together healthy physiological function. Lessons learned suggest potentially modulate cell subsets needed implantation have morphology. Microbiota also crucial infections defending niche competing Our highlights need well-designed 'baseline' microbial representing optimal starting point subsequent placenta formation.The complex interplay processes involved pregnancy still poorly understood. correct state, including environment, not only but formation since initiation placentation highly cells. Implantation failure, recurrent loss, pathologies placenta, pre-eclampsia, represent an increasing societal burden. More robust are colonization. current data, future research needs include relevant factor order understand players pregnancy.

Language: Английский

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Gut Microbiota, Immune System, and Bone

Calcified Tissue International, Journal Year: 2017, Volume and Issue: 102(4), P. 415 - 425

Published: Sept. 30, 2017

Language: Английский

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Emerging roles of bile acids in mucosal immunity and inflammation

Mucosal Immunology, Journal Year: 2019, Volume and Issue: 12(4), P. 851 - 861

Published: April 5, 2019

Bile acids are cholesterol-derived surfactants that circulate actively between the liver and ileum classically recognized for emulsifying dietary lipids to facilitate absorption. More recent studies, however, have revealed new functions of bile acids; as pleotropic signaling metabolites regulate diverse metabolic inflammatory pathways in multiple cell types tissues through dynamic interactions with both germline-encoded host receptors microbiota. Accordingly, perturbed acid circulation and/or metabolism is now implicated pathogenesis cholestatic diseases, syndrome, colon cancer, bowel diseases (IBDs). Here, we discuss three-dimensional interplay acids, microbiota, mucosal immune system, focusing on mechanisms intestinal homeostasis inflammation. Although regulation only beginning be appreciated, targeting their cellular has already proven an important area drug discovery.

Language: Английский

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Short-chain fatty acids: linking diet, the microbiome and immunity

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(8), P. 577 - 595

Published: April 2, 2024

Language: Английский

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