Sulforaphane reduces obesity by reversing leptin resistance DOI Creative Commons
Işın Çakır, Pauline Lining Pan, Colleen K. Hadley

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: March 1, 2022

The ascending prevalence of obesity in recent decades is commonly associated with soaring morbidity and mortality rates, resulting increased health-care costs decreased quality life. A systemic state stress characterized by low-grade inflammation pathological formation reactive oxygen species (ROS) usually manifests obesity. transcription factor nuclear erythroid-derived 2-like 2 (NRF2) the master regulator redox homeostasis plays a critical role resolution inflammation. Here, we show that natural isothiocyanate potent NRF2 activator sulforaphane reverses diet-induced through predominantly, but not exclusively, NRF2-dependent mechanism requires functional leptin receptor signaling hyperleptinemia. Sulforaphane does reduce body weight or food intake lean mice induces an anorectic response when coadministered exogenous leptin. Leptin-deficient Lep ob/ob mutant Lepr db/db display resistance to weight-reducing effect sulforaphane, supporting conclusion antiobesity signaling. Furthermore, our results suggest skeletal muscle as most notable site action whose peripheral signals alleviate resistance. Transcriptional profiling six major metabolically relevant tissues highlights suppresses fatty acid synthesis while promoting ribosome biogenesis, reducing ROS accumulation, resolving inflammation, therefore representing unique transcriptional program leads protection from Our findings argue for clinical evaluation loss obesity-associated metabolic disorders.

Language: Английский

Central regulation of food intake in fish: an evolutionary perspective DOI Open Access
José L. Soengas, José Miguel Cerdá‐Reverter, M.J. Delgado

et al.

Journal of Molecular Endocrinology, Journal Year: 2018, Volume and Issue: 60(4), P. R171 - R199

Published: Feb. 22, 2018

Evidence indicates that central regulation of food intake is well conserved along the vertebrate lineage, at least between teleost fish and mammals. However, several differences arise in comparison both groups. In this review, we describe similarities mammals on an evolutionary perspective. We focussed existing knowledge specific features conditioning intake, anatomical homologies analogies groups as main signalling pathways neuroendocrine metabolic nature involved homeostatic hedonic intake.

Language: Английский

Citations

136
Natural and Drug Rewards Engage Distinct Pathways that Converge on Coordinated Hypothalamic and Reward Circuits DOI Creative Commons
Amber L. Alhadeff, Nitsan Goldstein,

Onyoo Park

et al.

Neuron, Journal Year: 2019, Volume and Issue: 103(5), P. 891 - 908.e6

Published: July 2, 2019

Language: Английский

Citations

112
Neural Control and Modulation of Thirst, Sodium Appetite, and Hunger DOI Creative Commons
Vineet Augustine, Sangjun Lee, Yuki Oka

et al.

Cell, Journal Year: 2020, Volume and Issue: 180(1), P. 25 - 32

Published: Jan. 1, 2020

Language: Английский

Citations

106
Microbiota‐gut‐brain axis as a regulator of reward processes DOI
Rubén García‐Cabrerizo, Carina Carbia,

Kenneth J. O ́Riordan

et al.

Journal of Neurochemistry, Journal Year: 2020, Volume and Issue: 157(5), P. 1495 - 1524

Published: Dec. 26, 2020

Abstract Our gut harbours trillions of microorganisms essential for the maintenance homeostasis and host physiology in health disease. In last decade, there has been a growing interest understanding bidirectional pathway communication between our microbiota central nervous system. With regard to reward processes is accumulating evidence from both animal human studies that this axis may be key factor gating valence. Focusing on mesocorticolimbic pathway, we will discuss how intestinal involved regulating brain functions, natural (i.e. eating, social or sexual behaviours) non‐natural reinforcers (drug addiction behaviours including those relevant alcohol, psychostimulants, opioids cannabinoids). We integrate preclinical clinical suggesting microbiota‐gut‐brain could implicated development disorders associated with alterations system it targeted as promising therapeutic strategy. image Cover Image issue: https://doi.org/10.1111/jnc.15065 .

Language: Английский

Citations

106
Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions DOI Creative Commons
Chi Kin Ip, Lei Zhang, Aitak Farzi

et al.

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(1), P. 111 - 128.e6

Published: April 25, 2019

Language: Английский

Citations

103
Central nervous system regulation of organismal energy and glucose homeostasis DOI
Martin G. Myers, Alison H. Affinati, Nicole E. Richardson

et al.

Nature Metabolism, Journal Year: 2021, Volume and Issue: 3(6), P. 737 - 750

Published: June 21, 2021

Language: Английский

Citations

102
A Farewell to Art: Aesthetics as a Topic in Psychology and Neuroscience DOI
Martin Skov, Marcos Nadal

Perspectives on Psychological Science, Journal Year: 2020, Volume and Issue: 15(3), P. 630 - 642

Published: Feb. 6, 2020

Empirical aesthetics and neuroaesthetics study two main issues: the valuation of sensory objects art experience. These issues are often treated as if they were intrinsically interrelated: Research on experience focuses how elicits aesthetic pleasure, research special categories or emotional processes that determine This entanglement hampers progress in empirical limits their relevance to other domains psychology neuroscience. Substantial these fields is possible only disentangled from art. We define why stimuli acquire hedonic value. Under this definition, becomes a fundamental topic for neuroscience because it links hedonics (the what itself) neuroeconomics values integrated into decision making behavioral control). also propose definition leads concrete questions, such perceptual information comes engage value signals reward circuit different psychological neurobiological factors elicit appreciation events identical objects.

Language: Английский

Citations

96
Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females DOI Creative Commons
Jian Qiu,

Heidi M. Rivera,

Martha A. Bosch

et al.

eLife, Journal Year: 2018, Volume and Issue: 7

Published: Aug. 6, 2018

The neuropeptides tachykinin2 (Tac2) and kisspeptin (Kiss1) in hypothalamic arcuate nucleus Kiss1 (Kiss1ARH) neurons are essential for pulsatile release of GnRH reproduction. Since 17β-estradiol (E2) decreases Tac2 mRNA expression Kiss1ARH neurons, the role during E2-driven anorexigenic states their coordination POMC NPY/AgRP feeding circuits have been largely ignored. Presently, we show that E2 augmented excitability by amplifying Cacna1g, Hcn1 Hcn2 T-type calcium h-currents. increased Slc17a6 glutamatergic synaptic input to which excited inhibited via metabotropic receptors. Deleting eliminated glutamate led conditioned place preference sucrose E2-treated KO female mice. Therefore, increase neuronal neurotransmission may play a key governing motivational drive palatable food females.

Language: Английский

Citations

95
Identification of a neurocircuit underlying regulation of feeding by stress-related emotional responses DOI Creative Commons
Yuanzhong Xu, Yungang Lu, Ryan M. Cassidy

et al.

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Aug. 1, 2019

Abstract Feeding is known to be profoundly affected by stress-related emotional states and eating disorders are comorbid with psychiatric symptoms altered responses. The neural basis underlying feeding regulation changes poorly understood. Here, we identify a novel projection from the paraventricular hypothalamus (PVH) ventral lateral septum (LSv) that shows scalable on behavioral related emotion. Weak photostimulation of glutamatergic PVH→LSv terminals elicits self-grooming strong causes fear-related escape jumping associated respective weak inhibition feeding. In contrast, inputs LSv increases signs reduced anxiety. LSv-projecting neurons concentrated in rostral PVH. PVH activated stressors vivo, whereas bouts were activity these neurons. Thus, neurotransmission underlies dynamic orchestrating states, providing circuit substrate comorbidity between abnormalities disorders.

Language: Английский

Citations

90
FGF21 and the Physiological Regulation of Macronutrient Preference DOI Creative Commons
Cristal M. Hill,

Emily Qualls‐Creekmore,

Hans‐Rudolf Berthoud

et al.

Endocrinology, Journal Year: 2020, Volume and Issue: 161(3)

Published: Feb. 12, 2020

Abstract The ability to respond variations in nutritional status depends on regulatory systems that monitor nutrient intake and adaptively alter metabolism feeding behavior during restriction. There is ample evidence the restriction of water, sodium, or energy triggers adaptive responses conserve existing stores promote ingestion missing nutrient, these homeostatic are mediated, at least part, by nutritionally regulated hormones acting within brain. This review highlights recent research suggests metabolic hormone fibroblast growth factor 21 (FGF21) acts brain homeostatically macronutrient preference. Circulating FGF21 levels robustly increased diets high carbohydrate but low protein, exogenous treatment reduces consumption sweet foods alcohol while alternatively increasing protein. In addition, control mice shift preference increase protein response dietary restriction, lack either signaling fail exhibit this response. therefore mediates a unique physiological niche, coordinating shifts serve maintain face

Language: Английский

Citations

78