Xenon gas as a potential treatment for opioid use disorder, alcohol use disorder, and related disorders DOI Creative Commons
Marc J. Kaufman, Edward G. Meloni

Medical Gas Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Xenon gas is considered to be a safe anesthetic and imaging agent. Research on its other potentially beneficial effects suggests that xenon may have broad efficacy for treating health disorders. A number of reviews applications been published, but none focused substance use Accordingly, we review targets relevant the treatment disorders, with focus opioid disorder alcohol disorder. We report inhaled at subsedative concentrations inhibits conditioned memory reconsolidation withdrawal symptoms. work by others reporting antidepressant, anxiolytic, analgesic properties xenon, which could diminish negative affective states pain. discuss research supporting possibility prevent analgesic- or stress-induced tolerance and, so doing reduce risk developing The rapid kinetics, favorable safety side effect profiles, multitargeting capability suggest it used as an ambulatory on-demand rapidly attenuate maladaptive memory, physical symptoms, pain drivers disorders when they occur. also human immunodeficiency virus oncology because exploited target reservoirs, protein-induced abnormalities, cancers. Although expensive, low exert effects, separation, recovery, recycling advancements will lower costs, increasing economic feasibility therapeutic use. More needed better understand remarkable repertoire potential applications.

Language: Английский

Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration DOI Creative Commons
Stanisław Szlufik,

Kamila Kopeć,

Stanisław Szleszkowski

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(3), P. 286 - 286

Published: Feb. 5, 2024

The key to the effective treatment of neurodegenerative disorders is a thorough understanding their pathomechanism. Neurodegeneration and neuroinflammation are mutually propelling brain processes. An impairment glymphatic system function in neurodegeneration contributes progression pathological question arises as how related. This review highlights direct indirect influence these two seemingly independent Protein aggregates, characteristic feature neurodegeneration, correlated with clearance neuroinflammation. Glial cells cannot be overlooked when considering neuroinflammatory Astrocytes essential for functioning play crucial role inflammatory responses central nervous system. It imperative acknowledge significance AQP4, protein that exhibits high degree polarization astrocytes AQP4 influences processes have not yet been clearly delineated. Another interesting issue gut–brain axis microbiome, which potentially impact discussed A discussion correlation between may contribute exploring pathomechanism neurodegeneration.

Language: Английский

Citations

16
Gut microbiota-related neuroinflammation at the crossroad of food reward alterations: implications for eating disorders DOI Creative Commons
Sabrina J. P. Huwart, Nuria Morales‐Puerto, Amandine Everard

et al.

Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 333397

Published: Feb. 17, 2025

The link between gut microbiome and eating behaviours, especially palatable food intake, is a growing focus of scientific investigation. complex ecosystem microorganisms in the influences host metabolism, immune function neurobehavioural signalling. This review explores role neuroinflammation dysregulations food-induced reward signalling potential causal microbiota on these proinflammatory processes. Particular attention given to disorders (ED, specifically anorexia nervosa, binge disorder bulimia nervosa) links with microbiota, alterations neuroinflammation. Finally, we propose modulation as promising therapeutic strategy ED.

Language: Английский

Citations

2
Diet and the microbiota–gut–brain-axis: a primer for clinical nutrition DOI Creative Commons
Gabriela Ribeiro,

Aimone Ferri,

Gerard Clarke

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2022, Volume and Issue: 25(6), P. 443 - 450

Published: Sept. 14, 2022

Diet is an essential modulator of the microbiota - gut brain communication in health and disease. Consequently, diet-induced microbiome states can impact behaviour. The integration into clinical nutrition perspectives sparse. This review will thus focus on emerging evidence microbiome-targeted dietary approaches with potential to improve disorders.

Language: Английский

Citations

42
The Microbiome-Gut-Brain axis regulates social cognition & craving in young binge drinkers DOI Creative Commons
Carina Carbia, Thomaz F. S. Bastiaanssen, Luigi Francesco Iannone

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 89, P. 104442 - 104442

Published: Feb. 2, 2023

Language: Английский

Citations

34
Role of the intestinal microbiota in contributing to weight disorders and associated comorbidities DOI
Matthias Van Hul, Audrey M. Neyrinck, Amandine Everard

et al.

Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(3)

Published: June 28, 2024

SUMMARY The gut microbiota is a major factor contributing to the regulation of energy homeostasis and has been linked both excessive body weight accumulation fat mass (i.e., overweight, obesity) or loss, weakness, muscle atrophy, depletion cachexia). These syndromes are characterized by multiple metabolic dysfunctions including abnormal food reward intake, storage, low-grade inflammation. Given increasing worldwide prevalence obesity, cachexia, associated disorders, novel therapeutic strategies needed. Among different mechanisms explaining how capable influencing host metabolism balance, numerous studies have investigated complex interactions existing between nutrition, microbes, their metabolites. In this review, we discuss microbes microbiota-derived metabolites regulate metabolism. We describe role barrier function in onset inflammation context. explore importance gut-to-brain axis glucose but also key played liver. Finally, present specific examples using targeted approaches such as prebiotics probiotics might affect metabolites, signaling pathways, with reflect on challenges move from bench bedside.

Language: Английский

Citations

15
A gut (microbiome) feeling about addiction: Interactions with stress and social systems DOI Creative Commons
Rubén García‐Cabrerizo, John F. Cryan

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 30, P. 100629 - 100629

Published: March 18, 2024

In recent years, an increasing attention has given to the intricate and diverse connection of microorganisms residing in our gut their impact on brain health central nervous system disease. There been a shift mindset understand that drug addiction is not merely condition affects brain, it now being recognized as disorder also involves external factors such intestinal microbiota, which could influence vulnerability development addictive behaviors. Furthermore, stress social interactions, are closely linked powerful modulators addiction. This review delves into mechanisms through microbiota-stress-immune axis may shape work integrates preclinical clinical evidence demonstrate bidirectional communication between stress, behaviors, substance use disorders suggesting microbes might modulate having significance

Language: Английский

Citations

11
Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes DOI Creative Commons
Manuel Tomás Crespo, Laura Lucía Trebucq,

Camila Agustina Senna

et al.

Biomedical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100827 - 100827

Published: Jan. 1, 2025

The circadian system is composed by a central hypothalamic clock at the suprachiasmatic nuclei (SCN) that communicates with peripheral oscillators for daily coordination of behavior and physiology. SCN entrain to environmental 24-h light-dark (LD) cycle drive rhythms internal synchronizers such as core body temperature, hypothalamic-hypophysary hormones, sympathetic/parasympathetic activity, well behavioral feeding-fasting rhythms, which supply signals setting molecular clocks tissues. Steady phase relationships between keep homeostatic processes microbiota/microbiome composition/activity, metabolic supply/demand, energy balance, immunoinflammatory process, sleep amount quality, psychophysiological stress, etc. Indeed, risk health alterations increase when these are chronically changed prompting disruption (CD), occurring after sudden LD changes (so-called jet-lag), or due activity/feeding-rest/fasting rhythm respect cycles (as humans subjected nightwork, restricting food access rest in mice). Typical pathologies observed animal models CD epidemiological studies include syndrome, type-2 diabetes, obesity, chronic inflammation, cancer, disruption, decrease physical cognitive performance, mood, among others. present review discusses different aspects physiological dysregulations having altered potential translation human health.

Language: Английский

Citations

1
I "Gut" Rhythm: the microbiota as a modulator of the stress response and circadian rhythms DOI Creative Commons
Gabriel S. S. Tofani, Gerard Clarke, John F. Cryan

et al.

FEBS Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Modern habits are becoming more and disruptive to health. As our days often filled with circadian disruption stress exposures, we need understand how responses these external stimuli shaped their mediators can be targeted promote A growing body of research demonstrates the role gut microbiota in influencing brain function behavior. The response rhythms, which essential maintaining appropriate environment, known impacted by microbiota. Gut microbes have been shown alter host's modulate rhythmicity. Although studies demonstrated strong links between microbiota, rhythms response, such were conducted an independent manner not conducive understanding interface factors. Due interconnected nature this review explore may play a regulating integration signals mammals consequences for health disease.

Language: Английский

Citations

1
The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease DOI Creative Commons
Samantha L. Dawson, Emma Todd, Alister C. Ward

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 329 - 329

Published: Jan. 31, 2025

Nutrition, the gut microbiota and immunity are all important factors in maintenance of health. However, there is a growing realization complex interplay between these elements coalescing nutrition-gut microbiota-immunity axis. This regulatory axis critical for health with disruption being implicated broad range diseases, including autoimmune disorders, allergies mental disorders. new perspective continues to underpin number innovative therapeutic strategies targeting different this treat relevant diseases. review describes inter-relationships nutrition, immunity. It then details several human diseases where has been identified presents examples how various may be targeted therapeutically as alternate treatment

Language: Английский

Citations

1
Microbiota and body weight control: Weight watchers within? DOI Creative Commons
Serena Boscaini, Sarah‐Jane Leigh, Aonghus Lavelle

et al.

Molecular Metabolism, Journal Year: 2021, Volume and Issue: 57, P. 101427 - 101427

Published: Dec. 29, 2021

Despite several decades of research, managing body weight remains an unsolved clinical problem. Health problems associated with dysregulated weight, such as obesity and cachexia, exhibit gut microbiota alterations. There is increased interest in utilising the for control, it responds to intervention plays important role energy extraction from food, well biotransformation nutrients.

Language: Английский

Citations

44