Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum DOI Creative Commons
Suzanne van der Veldt, Guillaume Etter, Coralie‐Anne Mosser

et al.

PLoS Biology, Journal Year: 2021, Volume and Issue: 19(8), P. e3001383 - e3001383

Published: Aug. 30, 2021

The hippocampal spatial code's relevance for downstream neuronal populations-particularly its major subcortical output the lateral septum (LS)-is still poorly understood. Here, using calcium imaging combined with unbiased analytical methods, we functionally characterized and compared tuning of LS GABAergic cells to those dorsal CA3 CA1 cells. We identified a significant number that are modulated by place, speed, acceleration, direction, as well conjunctions these properties, directly comparable spatially Interestingly, Bayesian decoding position based on reflected animal's location accurately activity pyramidal A portion showed stable codes over course multiple days, potentially reflecting long-term episodic memory. distributions exhibiting properties formed gradients along anterior-posterior dorsal-ventral axes LS, topographical organization inputs LS. Finally, show transsynaptic tracing neurons receiving excitatory input send projections hypothalamus medial septum, regions not targeted principal hippocampus. Together, our findings demonstrate robustly represents spatial, directional self-motion information is uniquely positioned relay this from hippocampus regions, thus occupying key within distributed memory network.

Language: Английский

Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways DOI Creative Commons

Candace Alicia Rizzi-Wise,

Dong V. Wang

eNeuro, Journal Year: 2021, Volume and Issue: 8(6), P. ENEURO.0315 - 21.2021

Published: Nov. 1, 2021

Abstract The lateral septum (LS) is implicated as a hub that regulates variety of affects, such reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated structure homogeneity, exhibits multifaceted functions. Emerging evidence suggests different functions LS are mediated largely by its diverse input output connections. It has also become clear heterogeneous region, where dorsal ventral poles play dissociable often opposing roles. This functional heterogeneity can be explained distinct hippocampal inputs along dorsoventral axis, well antagonizing connections between subregions. Similarly, outputs from subregions to respective downstream targets, hypothalamic, preoptic, tegmental areas, account for this heterogeneity. In review, we provide an updated perspective on subregion classification, connectivity, We identify key questions have yet addressed in field.

Language: Английский

Citations

107
Top-down regulation of motivated behaviors via lateral septum sub-circuits DOI Creative Commons
B Antoine, Félix Leroy

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(8), P. 3119 - 3128

Published: May 18, 2022

Abstract How does cognition regulate innate behaviors? While the cognitive functions of cortex have been extensively studied, we know much less about how can motivated behaviors to fulfill physiological, safety and social needs. Selection appropriate depends on external stimuli past experiences that helps scale priorities. With its abundant inputs from neocortical allocortical regions, lateral septum (LS) is ideally positioned integrate perception experience signals in order activity hypothalamic midbrain nuclei control behaviors. In addition, LS receives numerous subcortical modulatory inputs, which represent animal internal states also participate this regulation. perspective, argue sub-circuits distinct by integrating neural neocortical, neuromodulatory inputs. propose inhibition between may allow emergence functional units orchestrates competing

Language: Английский

Citations

75
A limbic circuitry involved in emotional stress-induced grooming DOI Creative Commons
Mingdao Mu, Hong-Yan Geng,

Kang‐Lin Rong

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: May 8, 2020

Abstract Prolonged exposure to negative stressors could be harmful if a subject cannot respond appropriately. Strategies evolved stress, including repetitive displacement behaviours, are important in maintaining behavioural homoeostasis. In rodents, self-grooming is frequently observed behaviour believed contribute post-stress de-arousal with adaptive value. Here we identified rat limbic di-synaptic circuit that regulates stress-induced positive affective valence. This links hippocampal ventral subiculum lateral septum (LSv) and then hypothalamus tuberal nucleus. Optogenetic activation of this triggers delayed but robust excessive grooming patterns closely resembling those evoked by emotional stress. Consistently, the neural activity LSv reaches peak before while inhibition significantly suppresses triggered Our results uncover previously unknown circuitry involved regulating pinpoint critical role ethologically behaviour.

Language: Английский

Citations

86
Profound and redundant functions of arcuate neurons in obesity development DOI
Canjun Zhu, Zhiying Jiang, Yuanzhong Xu

et al.

Nature Metabolism, Journal Year: 2020, Volume and Issue: 2(8), P. 763 - 774

Published: July 27, 2020

Language: Английский

Citations

81
The hypothalamus for whole-body physiology: from metabolism to aging DOI Creative Commons
Tiemin Liu, Yong Xu, Chun‐Xia Yi

et al.

Protein & Cell, Journal Year: 2021, Volume and Issue: 13(6), P. 394 - 421

Published: April 7, 2021

Abstract Obesity and aging are two important epidemic factors for metabolic syndrome many other health issues, which contribute to devastating diseases such as cardiovascular diseases, stroke cancers. The brain plays a central role in controlling physiology that it integrates information from organs, sends regulatory projections orchestrates the whole-body function. Emerging studies suggest dysfunction sensing various internal cues or processing external may have profound effects on physiological functions. This review highlights linked genetic mutations, sex, inflammation, microbiota, stress causes pathophysiology, arguing root cause of obesity-related disorders. We also speculate key issues need be addressed how reveal relevant underlines development these disorders order develop new treatment strategies against problems.

Language: Английский

Citations

78
Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice DOI Creative Commons
Yun Feng Zhang,

Jialiang Wu,

Yingqi Wang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 28, 2023

Abstract The ventral striatum is a reward center implicated in the pathophysiology of depression. It contains islands Calleja, clusters dopamine D3 receptor-expressing granule cells, predominantly olfactory tubercle (OT). These OT neurons regulate self-grooming, repetitive behavior manifested affective disorders. Here we show that chronic restraint stress (CRS) induces robust depression-like behaviors mice and decreases excitability neurons. Ablation or inhibition these leads to behaviors, whereas their activation ameliorates CRS-induced behaviors. Moreover, has rewarding effect, which diminishes when grooming blocked. Finally, propose model explains how may influence release via synaptic connections with spiny projection (SPNs) project midbrain Our study reveals crucial role bidirectionally mediating suggesting potential therapeutic target.

Language: Английский

Citations

24
Neural circuits regulating visceral pain DOI Creative Commons
Xiaoli Chang, Haiyan Zhang, S.R. Wayne Chen

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: April 13, 2024

Abstract Visceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development chronic visceral pain, which is major challenge for both patients and health providers. Neural circuits in brain encode, store, transfer pain information across regions. In this review, we focus on anterior cingulate cortex paraventricular nucleus hypothalamus highlight progress identifying neural involved pain. We also discuss several circuit mechanisms emphasize importance cross-species, multiangle approaches identification specific neurons determining that control

Language: Английский

Citations

9
Dorsolateral septum GLP-1R neurons regulate feeding via lateral hypothalamic projections DOI Creative Commons
Yi Lu, Le Wang, Fang Luo

et al.

Molecular Metabolism, Journal Year: 2024, Volume and Issue: 85, P. 101960 - 101960

Published: May 17, 2024

Although glucagon-like peptide 1 (GLP-1) is known to regulate feeding, the central mechanisms contributing this function remain enigmatic. Here, we aim test role of neurons expressing GLP-1 receptors (GLP-1R) in dorsolateral septum (dLS; dLSGLP-1R) that project lateral hypothalamic area (LHA) on food intake and determine relationship with feeding regulation. Using chemogenetic manipulations, assessed how activation or inhibition dLSGLP-1R affected Glp1r-ires-Cre mice. Then, used channelrhodopsin-assisted circuit mapping, chemogenetics, electrophysiological recordings identify assess pathway from →LHA projections regulating intake. Chemogenetic increases LHA a major downstream target neurons. The dLSGLP-1R→LHA are GABAergic, also promotes While modestly decreases intake, optogenetic stimulation projection terminals rapidly suppressed behavior. Finally, demonstrate GLP-1R agonist, Exendin 4 enhances GABA release. Together, these results dLS-GLP-1R inhibitory can behavior, which might serve as potential therapeutic for treatment eating disorders obesity.

Language: Английский

Citations

9
Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice DOI Creative Commons
Chang‐Rui Chen,

Yu-Heng Zhong,

Shan Jiang

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Nov. 17, 2021

Hypersomnolence disorder (HD) is characterized by excessive sleep, which a common sequela following stroke, infection, or tumorigenesis. HD traditionally thought to be associated with lesions of wake-promoting nuclei. However, single nucleus, even two simultaneously, did not exert serious HD. Therefore, the specific nucleus and neural circuitry for remain unknown. Here, we observed that paraventricular hypothalamus (PVH) exhibited higher c-fos expression during active period (23:00) than inactive (11:00) in mice. speculated PVH, most neurons are glutamatergic, may represent one key arousal-controlling centers. By using vesicular glutamate transporter 2 (vglut2 Cre ) mice together fiber photometry, multichannel electrophysiological recordings, genetic approaches, found PVH vglut2 were wakefulness. Chemogenetic activation induced wakefulness 9 hr, photostimulation →parabrachial complex/ventral lateral septum circuits immediately drove transitions from sleep Moreover, lesioning chemogenetic inhibition dramatically decreased These results indicate critical arousal promotion maintenance.

Language: Английский

Citations

50
Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward DOI Creative Commons
Jingjing Sun, Yuan Yuan,

Xiaohua Wu

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(20), P. 3356 - 3373.e8

Published: Sept. 6, 2022

The use of body-focused repetitive behaviors (BFRBs) is conceptualized as a means coping with stress. However, the neurological mechanism by which affect anxiety regulation unclear. Here, we identify that excitatory somatostatin-positive neurons in medial paralemniscal nucleus (MPLSST neurons) mice promote self-grooming and encode reward. MPLSST display prominent grooming-related neuronal activity. Loss function impairs both post-stress alleviation. Activation rewarding sufficient to drive reinforcement activating dopamine (DA) ventral tegmental area (VTA) eliciting release. neuropeptide SST facilitates impact neurons. neuron-mediated triggered input from central amygdala (CeA). Our study reveals dual role CeA-MPLSST-VTADA circuit conceptualizes an interface linking stress reward systems mice.

Language: Английский

Citations

35