Cancer metabolism: looking forward

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(10), P. 669 - 680

Published: July 16, 2021

Language: Английский

---

COVID-19: the vasculature unleashed

Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 20(7), P. 389 - 391

Published: May 21, 2020

Language: Английский

---

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Cell, Journal Year: 2020, Volume and Issue: 180(4), P. 764 - 779.e20

Published: Feb. 1, 2020

Language: Английский

---

Targeting cancer metabolism in the era of precision oncology

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 21(2), P. 141 - 162

Published: Dec. 3, 2021

Language: Английский

---

Pregnancy and COVID-19

Physiological Reviews, Journal Year: 2020, Volume and Issue: 101(1), P. 303 - 318

Published: Sept. 24, 2020

There are many unknowns for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. Clinical experience of pregnancies complicated with infection by other coronaviruses e.g., Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Syndrome, has led to woman being considered potentially vulnerable severe SARS-CoV-2 infection. Physiological changes pregnancy have a significant impact on immune system, respiratory cardiovascular function, coagulation. These may positive or negative effects COVID-19 progression. The in remains be determined, concerted, global effort is required determine implantation, fetal growth development, labor, neonatal health. Asymptomatic presents further challenge regarding service provision, prevention, management. Besides direct impacts disease, plethora indirect consequences pandemic adversely affect maternal health, including reduced access reproductive health services, increased mental strain, socioeconomic deprivation. In this review, we explore current knowledge highlight areas research minimize its their children.

Language: Английский

---

Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science

Cardiovascular Research, Journal Year: 2020, Volume and Issue: 116(14), P. 2177 - 2184

Published: July 24, 2020

The COVID-19 pandemic is an unprecedented healthcare emergency causing mortality and illness across the world. Although primarily affecting lungs, SARS-CoV-2 virus also affects cardiovascular system. In addition to cardiac effects, e.g. myocarditis, arrhythmias, myocardial damage, vasculature affected in COVID-19, both directly by virus, indirectly as a result of systemic inflammatory cytokine storm. This includes role vascular endothelium recruitment leucocytes where they contribute tissue damage release, which are key drivers acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation, complications COVID-19. There evidence linking endothelial cells (ECs) infection including: (i) expression function its receptor angiotensin-converting enzyme 2 (ACE2) vasculature; (ii) prevalence Kawasaki disease-like (vasculitis) COVID-19; (iii) EC with patients fatal Here, Working Group on Atherosclerosis Vascular Biology together Council Basic Cardiovascular Science European Society Cardiology provide Position Statement importance underlying pathophysiology behind clinical presentation identify questions for future research address. We propose that biomarkers tests (e.g. flow-mediated dilatation) should be evaluated their usefulness risk stratification patients. A better understanding effects biology micro- macrovasculature required, testing considered follow-up convalescent early detection long-term complications.

Language: Английский

---

Basic and Therapeutic Aspects of Angiogenesis Updated

Circulation Research, Journal Year: 2020, Volume and Issue: 127(2), P. 310 - 329

Published: July 2, 2020

All organisms growing beyond the oxygen diffusion limit critically depend on a functional vasculature for survival. Yet blood vessels are far more than passive, uniform conduits and nutrient supply. A remarkable organotypic heterogeneity is brought about by tissue-specific differentiated endothelial cells (lining vessels’ lumen) allows to deal with organ-specific demands homeostasis. On flip side, when go awry, they promote life-threatening diseases characterized inappropriately adopting an angiogenic state (eg, tumor vascularization) or becoming dysfunctional diabetic microvasculopathies), calling respectively antiangiogenic therapies proangiogenic/vascular regenerative strategies. In solid tumors, despite initial enthusiasm, growth factor–based (mostly anti-VEGF [vascular factor]) do not sufficiently live up expectations in terms of efficiency patient survival, part, due intrinsic acquired therapy resistance. Tumors cunningly deploy alternative factors ones targeted reinstigate angiogenesis revert other ways securing flow, independently factors. trying alleviate tissue ischemia repair damaged endothelium, local in-tissue administration (genes encoding) proangiogenic (stem) harnessing potential have been explored. Notwithstanding evaluation clinical trials, these approaches often hampered dosing issues limited half-life retention administered agents. Here, without intending provide all-encompassing historical overview, we focus some recent advances understanding cell behavior health disease identify novel molecular players concepts that could eventually be considered therapeutic targeting.

Language: Английский

---

Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis

Cardiovascular Research, Journal Year: 2020, Volume and Issue: 117(1), P. 29 - 42

Published: April 7, 2020

Abstract Endothelial cells (ECs) are sentinels of cardiovascular health. Their function is reduced by the presence risk factors, and regained once pathological stimuli removed. In this European Society for Cardiology Position Paper, we describe endothelial dysfunction as a spectrum phenotypic states advocate further studies to determine role EC subtypes in disease. We conclude that there no single ideal method measurement function. Techniques measure coronary epicardial micro-vascular well established but they invasive, time-consuming, expensive. Flow-mediated dilatation (FMD) brachial arteries provides non-invasive alternative technically challenging requires extensive training standardization. We, therefore, propose consensus methodology FMD universally adopted minimize technical variation between studies, reference values different populations healthy individuals patient groups. Newer techniques relatively easy perform, such finger plethysmography retinal flicker test, have potential increased clinical use provided achieved on protocol used. recommend establish these assess their ability improve stratification. future whether integration measurements with patient-specific epigenetic data other biomarkers can enhance stratification patients differential diagnosis, disease progression, responses therapy.

Language: Английский

---

Metabolic programming and immune suppression in the tumor microenvironment

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 421 - 433

Published: Feb. 16, 2023

Language: Английский

---

Mechanoresponsive metabolism in cancer cell migration and metastasis

Cell Metabolism, Journal Year: 2021, Volume and Issue: 33(7), P. 1307 - 1321

Published: April 28, 2021

Language: Английский

---