International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(2), P. 1698 - 1698
Published: Jan. 15, 2023
High-altitude
illnesses
(HAIs)
result
from
acute
exposure
to
high
altitude/hypoxia.
Numerous
molecular
mechanisms
affect
appropriate
acclimatization
hypobaric
and/or
normobaric
hypoxia
and
curtail
the
development
of
HAIs.
The
understanding
these
is
essential
optimize
hypoxic
for
efficient
prophylaxis
treatment
This
review
aims
link
outcomes
either
adverse
effects
high-altitude/hypoxia
or
developing
tolerance
with
acclimatization.
After
summarizing
systemic
physiological
responses
high-altitude
exposure,
associated
acclimatization,
epidemiology
pathophysiology
various
HAIs,
article
focuses
on
adjustments
maladjustments
during
Pivotal
modifying
include
orchestrated
by
transcription
factors,
most
notably
inducible
reciprocal
mitochondrial
functions
REDOX
homeostasis.
In
addition,
discussed
are
genetic
factors
resultant
proteomic
profiles
determining
hypoxia-modifying
culminating
in
successful
Lastly,
discusses
practical
considerations
related
aspects
altitude
training
strategies.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Dec. 16, 2022
Aging
is
a
gradual
and
irreversible
pathophysiological
process.
It
presents
with
declines
in
tissue
cell
functions
significant
increases
the
risks
of
various
aging-related
diseases,
including
neurodegenerative
cardiovascular
metabolic
musculoskeletal
immune
system
diseases.
Although
development
modern
medicine
has
promoted
human
health
greatly
extended
life
expectancy,
aging
society,
variety
chronic
diseases
have
gradually
become
most
important
causes
disability
death
elderly
individuals.
Current
research
on
focuses
elucidating
how
endogenous
exogenous
stresses
(such
as
genomic
instability,
telomere
dysfunction,
epigenetic
alterations,
loss
proteostasis,
compromise
autophagy,
mitochondrial
cellular
senescence,
stem
exhaustion,
altered
intercellular
communication,
deregulated
nutrient
sensing)
participate
regulation
aging.
Furthermore,
thorough
pathogenesis
to
identify
interventions
that
promote
longevity
caloric
restriction,
microbiota
transplantation,
nutritional
intervention)
clinical
treatment
methods
for
(depletion
senescent
cells,
therapy,
antioxidative
anti-inflammatory
treatments,
hormone
replacement
therapy)
could
decrease
incidence
turn
healthy
longevity.
Molecular Cell,
Journal Year:
2021,
Volume and Issue:
81(18), P. 3677 - 3690
Published: Sept. 1, 2021
The
evolution
of
AMPK
and
its
homologs
enabled
exquisite
responsivity
control
cellular
energetic
homeostasis.
Recent
work
has
been
critical
in
establishing
the
mechanisms
that
determine
activity,
novel
targets
action,
distribution
AMPK-mediated
networks
across
landscape.
role
as
a
hub
metabolic
led
to
intense
interest
pharmacologic
activation
therapeutic
avenue
for
number
disease
states,
including
obesity,
diabetes,
cancer.
As
such,
on
compartmentalization
AMPK,
downstream
targets,
systems
it
influences
progressed
recent
years.
variegated
homeostasis
revealed
key
insights
into
normal
biology
future
directions
AMPK-based
strategies.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(23), P. 13173 - 13173
Published: Dec. 6, 2021
Cellular
senescence
entails
a
state
of
an
essentially
irreversible
proliferative
arrest
in
which
cells
remain
metabolically
active
and
secrete
range
pro-inflammatory
proteolytic
factors
as
part
the
senescence-associated
secretory
phenotype.
There
are
different
types
senescent
cells,
can
be
induced
response
to
many
DNA
damage
signals.
Senescent
accumulate
tissues
organs
where
they
have
distinct
physiological
pathological
functions.
Despite
this
diversity,
all
must
able
survive
nondividing
while
protecting
themselves
from
positive
feedback
loops
linked
constant
activation
response.
This
capacity
requires
changes
core
cellular
programs.
Understanding
how
cell
undergo
extensive
their
transcriptional
programs,
metabolism,
heterochromatin
patterns,
structures
induce
common
is
crucial
preventing
cancer
development/progression
improving
health
during
aging.
In
review,
we
discuss
continuously
evolve
after
initial
highlight
unifying
features
that
define
state.
