Nature Cell Biology,
Journal Year:
2023,
Volume and Issue:
25(5), P. 672 - 684
Published: May 1, 2023
Abstract
Dietary
mono-unsaturated
fatty
acids
(MUFAs)
are
linked
to
longevity
in
several
species.
But
the
mechanisms
by
which
MUFAs
extend
lifespan
remain
unclear.
Here
we
show
that
an
organelle
network
involving
lipid
droplets
and
peroxisomes
is
critical
for
MUFA-induced
Caenorhabditis
elegans
.
upregulate
number
of
fat
storage
tissues.
Increased
droplet
necessary
predicts
remaining
lifespan.
Lipidomics
datasets
reveal
also
modify
ratio
membrane
lipids
ether
lipids—a
signature
associated
with
decreased
oxidation.
In
agreement
this,
decrease
oxidation
middle-aged
individuals.
Intriguingly,
not
only
but
peroxisome
number.
A
targeted
screen
identifies
genes
involved
co-regulation
peroxisomes,
reveals
induction
both
organelles
optimal
longevity.
Our
study
uncovers
homeostasis
regulation,
opening
new
avenues
interventions
delay
aging.
Journal of Hematology & Oncology,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: Sept. 12, 2023
Abstract
Lipid
metabolic
reprogramming
is
an
emerging
hallmark
of
cancer.
In
order
to
sustain
uncontrolled
proliferation
and
survive
in
unfavorable
environments
that
lack
oxygen
nutrients,
tumor
cells
undergo
transformations
exploit
various
ways
acquiring
lipid
increasing
oxidation.
addition,
stromal
immune
the
microenvironment
also
reprogramming,
which
further
affects
functional
phenotypes
responses.
Given
metabolism
plays
a
critical
role
supporting
cancer
progression
remodeling
microenvironment,
targeting
pathway
could
provide
novel
approach
treatment.
This
review
seeks
to:
(1)
clarify
overall
landscape
mechanisms
cancer,
(2)
summarize
landscapes
within
their
roles
progression,
(3)
potential
therapeutic
targets
for
metabolism,
highlight
combining
such
approaches
with
other
anti-tumor
therapies
new
opportunities
patients.
Cells,
Journal Year:
2023,
Volume and Issue:
12(5), P. 804 - 804
Published: March 4, 2023
Ferroptosis
is
a
form
of
regulated
cell
death
that
intricately
linked
to
cellular
metabolism.
In
the
forefront
research
on
ferroptosis,
peroxidation
polyunsaturated
fatty
acids
has
emerged
as
key
driver
oxidative
damage
membranes
leading
death.
Here,
we
review
involvement
(PUFAs),
monounsaturated
(MUFAs),
lipid
remodeling
enzymes
and
in
highlighting
studies
revealing
how
using
multicellular
model
organism
Caenorhabditis
elegans
contributes
understanding
roles
specific
lipids
mediators
ferroptosis.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: July 23, 2022
Nutriments
have
been
deemed
to
impact
all
physiopathologic
processes.
Recent
evidences
in
molecular
medicine
and
clinical
trials
demonstrated
that
adequate
nutrition
treatments
are
the
golden
criterion
for
extending
healthspan
delaying
ageing
various
species
such
as
yeast,
drosophila,
rodent,
primate
human.
It
emerges
develop
precision-nutrition
therapeutics
slow
age-related
biological
processes
treat
diverse
diseases.
However,
nutritive
advantages
frequently
diversify
among
individuals
well
organs
tissues,
which
brings
challenges
this
field.
In
review,
we
summarize
different
forms
of
dietary
interventions
extensively
prescribed
improvement
disease
treatment
pre-clinical
or
clinical.
We
discuss
nutrient-mediated
mechanisms
including
metabolic
regulators,
metabolism
pathways,
epigenetic
circadian
clocks.
Comparably,
describe
diet-responsive
effectors
by
influence
endocrinic,
immunological,
microbial
neural
states
responsible
improving
health
preventing
multiple
diseases
humans.
Furthermore,
expatiate
patterns
dietotheroapies,
fasting,
calorie-restricted
diet,
ketogenic
high-fibre
plants-based
protein
restriction
diet
with
specific
reduction
amino
acids
microelements,
potentially
affecting
morbid
states.
Altogether,
emphasize
profound
nutritional
therapy,
highlight
crosstalk
explored
critical
factors
individualized
therapeutic
approaches
predictors.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Dec. 27, 2022
Abstract
Ferroptosis
is
a
type
of
regulated
necrosis
caused
by
unrestricted
lipid
peroxidation
and
subsequent
plasma
membrane
rupture.
However,
the
remodeling
mechanism
that
determines
sensitivity
to
ferroptosis
remains
poorly
understood.
Here,
we
report
previously
unrecognized
role
for
flippase
solute
carrier
family
47
member
1
(SLC47A1)
as
regulator
survival
during
ferroptosis.
Among
49
phospholipid
scramblases,
flippases,
floppases
analyzed,
only
SLC47A1
had
mRNA
was
selectively
upregulated
in
multiple
cancer
cells
exposed
ferroptotic
inducers.
Large-scale
lipidomics
functional
analyses
revealed
silencing
increased
RSL3-
or
erastin-induced
favoring
ACSL4-SOAT1–mediated
production
polyunsaturated
fatty
acid
cholesterol
esters.
We
identified
peroxisome
proliferator
activated
receptor
alpha
(PPARA)
transcription
factor
transactivates
SLC47A1.
The
depletion
PPARA
similarly
sensitized
induction,
whereas
transfection-enforced
re-expression
restored
resistance
PPARA-deficient
cells.
Pharmacological
genetic
blockade
PPARA-SLC47A1
pathway
anticancer
activity
inducer
mice.
These
findings
establish
direct
molecular
link
between
transporters,
which
may
provide
metabolic
targets
overcoming
drug
resistance.
