Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(7)
Published: March 22, 2024
Abstract
SBFI26,
an
inhibitor
of
FABP5,
has
been
shown
to
suppress
the
proliferation
and
metastasis
tumour
cells.
However,
underlying
mechanism
by
which
SBFI26
induces
ferroptosis
in
breast
cancer
cells
remains
largely
unknown.
Three
cell
lines
were
treated
with
CCK‐8
assessed
cytotoxicity.
Transcriptome
was
performed
on
Illumina
platform
verified
qPCR.
Western
blot
evaluated
protein
levels.
Malondialdehyde
(MDA),
total
superoxide
dismutase
(T‐SOD),
Fe,
glutathione
(GSH)
oxidized
(GSSG)
measured.
induced
death
time‐
dose‐dependent,
a
more
significant
inhibitory
effect
MDA‐MB‐231
Fer‐1,
GSH
Vitamin
C
attenuated
effects
but
not
erastin.
RNA‐Seq
analysis
revealed
that
treatment
significantly
enriched
differentially
expressed
genes
related
ferroptosis.
Furthermore,
increased
intracellular
MDA,
iron
ion,
GSSG
levels
while
decreasing
T‐SOD,
(T‐GSH),
levels.SBFI26
dose‐dependently
up‐regulates
expression
HMOX1
ALOX12
at
both
gene
levels,
promoting
Similarly,
it
increases
SAT1,
ALOX5,
ALOX15,
ALOXE3
CHAC1
that,
downregulating
NFE2L2
inhibit
leads
cellular
accumulation
fatty
acids,
triggers
excess
ferrous
ions
subsequent
lipid
peroxidation
for
inducing
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(8), P. 1628 - 1628
Published: Aug. 17, 2023
Alzheimer’s
disease
(AD)
is
a
brain
disorder
that
progressively
undermines
memory
and
thinking
skills
by
affecting
the
hippocampus
entorhinal
cortex.
The
main
histopathological
hallmarks
of
AD
are
presence
abnormal
protein
aggregates
(Aβ
tau),
synaptic
dysfunction,
aberrant
proteostasis,
cytoskeletal
abnormalities,
altered
energy
homeostasis,
DNA
RNA
defects,
inflammation,
neuronal
cell
death.
However,
oxidative
stress
or
damage
also
evident
commonly
overlooked
considered
consequence
advancement
dementia
symptoms.
control
onset
linked
to
activity
amyloid-β
peptide,
which
may
serve
as
both
antioxidant
pro-oxidant
molecules.
Furthermore,
correlated
with
proteins,
nucleic
acids,
lipids
in
vulnerable
populations,
ultimately
lead
death
through
different
molecular
mechanisms.
By
recognizing
an
integral
feature
AD,
alternative
therapeutic
preventive
interventions
developed
tested
potential
complementary
therapies
for
this
devastating
neurodegenerative
disease.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(35)
Published: June 27, 2024
Cuproptosis
is
a
novel
copper-dependent
programmed
cell
death.
The
efficacy
of
cuproptosis
highly
dependent
on
intracellular
copper
accumulation
and
counteracted
by
high
level
glutathione
(GSH)
in
tumor
cells.
Here,
this
work
develops
self-amplified
nanoparticles
(Cel-Cu
NP)
using
celastrol
(Cel),
natural
product
isolated
from
medical
plant.
In
Cel-Cu
NP,
Cel
serves
as
versatile
ionophore,
exhibiting
an
ideal
coordination
capacity
toward
ions
without
compromising
the
induction.
Notably,
can
simultaneously
scavenge
GSH
content
to
amplify
cuproptosis.
Moreover,
further
activates
immunogenic
death
(ICD)
elicit
robust
immune
response.
Combining
with
checkpoint
blockade,
NP
effectively
eradicates
metastatic
tumors
mouse
lung
metastasis
model.
This
study
provides
efficient
nanomedicine
inducing
for
immunotherapy.
Advances in Cancer Biology - Metastasis,
Journal Year:
2024,
Volume and Issue:
10, P. 100114 - 100114
Published: Jan. 17, 2024
A
significant
obstacle
to
treating
cancer
is
multidrug
resistance
(MDR),
which
the
capacity
of
cancerous
cells
develop
both
traditional
and
cutting-edge
chemotherapeutic
treatments.
Following
initial
discovery
that
cellular
pumps
reliant
on
ATP
were
root
chemotherapy
resistance,
more
research
has
revealed
involvement
additional
mechanisms,
including
increased
drug
metabolism,
reduced
entry,
compromised
apoptotic
pathways.
Numerous
projects
have
focused
MDR,
innumerable
been
conducted
better
understand
MDR
methods
mitigate
its
consequences.
Multidrug
(MDR)
a
key
challenge
in
cancer.
90%
cancer-related
fatalities
are
brought
by
tumor
metastasis
recurrence,
possible
with
MDR.
Drug
influenced
diverse
internal
extrinsic
variables,
genetic
epigenetic
changes,
efflux
systems,
DNA
repair
apoptosis,
autophagy.
In
this
review
paper,
we
list
potential
hazards
associated
therapy
general,
primarily
developing
theory
for
colorectal
particular.
We
discussed
unique
instance
malignancies
generally
5-fluorouracil,
curcumin,
lipids
as
viable
options
condition.
The
use
nanotechnology
(mainly
nanoparticles)
facilitated
vitro
well
vivo
efficacy
during
preclinical
phases,
summarized
below,
allowing
thorough
investigation
cancers
pancreatic
carcinomas
their
translation
following
clinical
trials.
Protein & Cell,
Journal Year:
2024,
Volume and Issue:
15(9), P. 642 - 660
Published: Feb. 29, 2024
Abstract
Cell
death
resistance
represents
a
hallmark
of
cancer.
Recent
studies
have
identified
metabolic
cell
as
unique
forms
regulated
resulting
from
an
imbalance
in
the
cellular
metabolism.
This
review
discusses
mechanisms
death—ferroptosis,
cuproptosis,
disulfidptosis,
lysozincrosis,
and
alkaliptosis—and
explores
their
potential
cancer
therapy.
Our
underscores
complexity
pathways
offers
insights
into
innovative
therapeutic
avenues
for
treatment.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(15), P. 10495 - 10508
Published: April 1, 2024
Sonodynamic
therapy
(SDT)
has
promising
application
prospects
in
tumor
therapy.
However,
SDT
does
not
eradicate
metastatic
tumors.
Herein,
Cu-substituted
ZnAl
ternary
layered
double
hydroxide
nanosheets
(ZCA
NSs)
were
developed
as
both
sonosensitizers
and
copper
nanocarriers
for
synergistic
SDT/cuproptosis
cancer
An
optimized
electronic
structure
more
conducive
to
the
sonodynamic
process
was
obtained
from
ZCA
NSs
via
Jahn–Teller
effect
induced
by
introduction
of
Cu2+,
synthesized
regulated
intricate
microenvironment
(TME)
depleting
endogenous
glutathione
(GSH)
amplify
oxidative
stress
further
enhanced
performance.
Furthermore,
cuproptosis
evoked
intracellular
overload
Cu2+
amplified
SDT,
leading
irreversible
proteotoxicity.
In
vitro
results
showed
that
such
synergetic
triggered
immunogenic
cell
death
(ICD)
promoted
maturation
dendritic
cells
(DCs).
as-synthesized
NS-mediated
thoroughly
eradicated
vivo
solid
tumors
simultaneously
elicited
antitumor
immunity
suppress
lung
liver
metastasis.
Overall,
this
work
established
a
nanoplatform
with
satisfactory
immunity.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(30)
Published: May 4, 2024
Abstract
Low
efficacy
of
immunotherapy
due
to
the
poor
immunogenicity
most
tumors
and
their
insufficient
infiltration
by
immune
cells
highlights
importance
inducing
immunogenic
cell
death
activating
system
for
achieving
better
treatment
outcomes.
Herein,
ferroelectric
Bi
2
CuO
4
nanoparticles
with
rich
copper
vacancies
(named
BCO‐V
Cu
)
are
rationally
designed
engineered
ferroelectricity‐enhanced
apoptosis,
cuproptosis,
subsequently
evoked
immunotherapy.
In
this
structure,
suppressed
recombination
electron–hole
pairs
band
bending
polarization
lead
high
catalytic
activity,
triggering
reactive
oxygen
species
bursts
apoptosis.
The
fragments
produced
apoptosis
serve
as
antigens
activate
T
cells.
Moreover,
generated
charge
catalysis,
nanomedicine
can
act
“a
smart
switch”
open
membrane,
promote
nanomaterial
endocytosis,
shut
down
+
outflow
pathway
evoke
thus
a
strong
response
is
triggered
reduced
content
adenosine
triphosphate.
Ribonucleic
acid
transcription
tests
reveal
pathways
related
activation.
Thus,
study
firstly
demonstrates
feasible
strategy
enhancing
using
single
semiconductor‐induced
cuproptosis.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(37)
Published: April 25, 2024
Abstract
Cuproptosis
and
ferroptosis
hold
great
promise
for
overcoming
apoptotic
resistance
in
liver
cancer
based
on
their
unique
metal‐driven
cell
death
modalities.
However,
insufficient
intracellular
copper
iron
concentration,
complicated
tumor
microenvironment
(TME),
unclear
cross‐regulatory
mechanisms
between
cuproptosis
ferroptosis,
severely
restrict
the
therapeutic
performance.
Herein,
copper‐doped
hollow
Prussian
blue
(CHP)
nanozymes
are
rationally
designed
loading
photosensitizer
indocyanine
green
(ICG)
O
2
‐saturated
perfluorohexane
(PFH),
denoted
as
‐PFH@CHPI
nanoparticles,
to
induce
ferroptosis.
In
response
specific
TME,
CHP
can
synergistically
catalyze
Fenton
reactions
consume
endogenous
glutathione,
leading
accumulation
of
reactive
oxygen
species.
Upon
near‐infrared
irradiation,
‐PFH@CHPI‐enabled
photothermal
effect
simultaneously
accelerate
catalytic
trigger
release
photodynamic
therapy
promote
oxidative
stress.
Notably,
be
effectively
activated
through
Cu
+
‐mediated
dihydrolipoamide
S‐acetyltransferase
aggregation
Fe–S
cluster
protein
loss.
Concurrently,
tilt
redox
balance
is
favorable
lipid
peroxidation
glutathione
peroxidase
4
inactivation,
resulting
an
augmented
effect.
Mechanistically,
stress‐boosted
jointly
disrupt
mitochondrial
metabolism,
which
turn
exacerbates
stress,
thus
realizing
a
mutually
enhanced
This
work
may
provide
new
guidance
utilizing
copper/ferrous‐engineering
cuproptosis/ferroptosis
synergetic
therapy.
