Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Nov. 21, 2022
Abstract
Muscle
regeneration
requires
the
coordination
of
muscle
stem
cells,
mesenchymal
fibro-adipogenic
progenitors
(FAPs),
and
macrophages.
How
macrophages
regulate
paracrine
secretion
FAPs
during
recovery
process
remains
elusive.
Herein,
we
systemically
investigated
communication
between
CD206
+
M2-like
using
a
transgenic
mouse
model.
Depletion
or
deletion
macrophages-specific
TGF-β1
gene
induces
myogenesis
regeneration.
We
show
that
depletion
activates
activated
secrete
follistatin,
promyogenic
factor,
thereby
boosting
process.
Conversely,
FAP-specific
follistatin
results
in
impaired
cell
function,
enhanced
fibrosis,
delayed
Mechanistically,
inhibit
FAP-derived
via
TGF-β
signaling.
Here
constitute
microenvironment
for
may
myogenic
potential
stem/satellite
cells.
BMC Medicine,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Dec. 27, 2022
Abstract
Obesity
usually
is
accompanied
by
inflammation
of
fat
tissue,
with
a
prominent
role
visceral
fat.
Chronic
in
obese
tissue
lower
grade
than
acute
immune
activation
for
clearing
the
from
an
infectious
agent.
It
loss
adipocyte
metabolic
homeostasis
that
causes
resident
cells
supporting
functions
and
regaining
homeostasis.
Initially,
excess
influx
lipids
glucose
context
overnutrition
met
growth
proliferation.
Eventual
lipid
overload
hypertrophic
adipocytes
leads
to
endoplasmic
reticulum
stress
secretion
variety
signals
causing
increased
sympathetic
tone,
lipolysis
adipocytes,
uptake
macrophages,
matrix
remodeling,
angiogenesis,
cell
activation.
Pro-inflammatory
signaling
system
release
amounts
pro-inflammatory
other
mediators
resulting
enhanced
tissue-protective
responses.
With
chronic
overnutrition,
these
protective
actions
are
insufficient,
death
as
well
senescence
several
types
seen.
This
structural
damage
expression
or
immunostimulatory
components
monocytes
many
types,
contribution
stromal
cells.
Matrix
remodeling
angiogenesis
further
intensified
possibly
detrimental
fibrosis.
The
accumulation
senescent
also
may
be
via
eventual
spread
state
affected
neighboring
microRNA-containing
vesicles.
Obese
can
viewed
initially
response
order
cope
ambient
nutrients
restore
but
contribute
at
later
stage.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: April 1, 2022
Abstract
The
combination
of
spatial
transcriptomics
(ST)
and
single
cell
RNA
sequencing
(scRNA-seq)
acts
as
a
pivotal
component
to
bridge
the
pathological
phenomes
human
tissues
with
molecular
alterations,
defining
in
situ
intercellular
communications
knowledge
on
spatiotemporal
medicine.
present
article
overviews
development
ST
aims
evaluate
clinical
translational
values
for
understanding
pathogenesis
uncovering
disease-specific
biomarkers.
We
compare
advantages
disadvantages
sequencing-
imaging-based
technologies
highlight
opportunities
challenges
ST.
also
describe
bioinformatics
tools
necessary
dissecting
patterns
gene
expression
cellular
interactions
potential
applications
diseases
practice
one
important
issues
medicine,
including
neurology,
embryo
development,
oncology,
inflammation.
Thus,
clear
objectives,
designs,
optimizations
sampling
procedure
protocol,
repeatability
ST,
well
simplifications
analysis
interpretation
are
key
translate
from
bench
clinic.
Endocrine Reviews,
Journal Year:
2022,
Volume and Issue:
44(2), P. 143 - 192
Published: May 29, 2022
Abstract
Brown
adipose
tissue
(BAT)
displays
the
unique
capacity
to
generate
heat
through
uncoupled
oxidative
phosphorylation
that
makes
it
a
very
attractive
therapeutic
target
for
cardiometabolic
diseases.
Here,
we
review
BAT
cellular
metabolism,
its
regulation
by
central
nervous
and
endocrine
systems
circulating
metabolites,
plausible
roles
of
this
in
human
thermoregulation,
energy
balance,
disorders,
current
knowledge
on
pharmacological
stimulation
humans.
The
definition
measurement
studies
relies
almost
exclusively
glucose
uptake
from
positron
emission
tomography
with
18F-fluorodeoxiglucose,
which
can
be
dissociated
thermogenic
activity,
as
example
insulin-resistant
states.
most
important
substrate
thermogenesis
is
intracellular
fatty
acid
content
mobilized
sympathetic
triglyceride
lipolysis.
This
lipolytic
response
intertwined
white
(WAT)
other
metabolic
tissues,
cannot
independently
stimulated
drugs
tested
thus
far.
an
interesting
biologically
has
yet
fully
selectively
activated
increase
body’s
shift
balance.
field
research
need
methods
able
directly,
specifically,
reliably
measure
while
also
tracking
related
responses
WAT
tissues.
Until
achieved,
uncertainty
will
remain
about
role
played
fascinating
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: March 15, 2023
Abstract
To
date,
single-cell
studies
of
human
white
adipose
tissue
(WAT)
have
been
based
on
small
cohort
sizes
and
no
cellular
consensus
nomenclature
exists.
Herein,
we
performed
a
comprehensive
meta-analysis
publicly
available
newly
generated
single-cell,
single-nucleus,
spatial
transcriptomic
results
from
subcutaneous,
omental,
perivascular
WAT.
Our
high-resolution
map
is
built
data
ten
allowed
us
to
robustly
identify
>60
subpopulations
adipocytes,
fibroblast
adipogenic
progenitors,
vascular,
immune
cells.
Using
these
results,
deconvolved
bulk
nine
additional
cohorts
provide
clinical
dimensions
the
map.
This
identified
cell-cell
interactions
as
well
relationships
between
specific
cell
subtypes
insulin
resistance,
dyslipidemia,
adipocyte
volume,
lipolysis
upon
long-term
weight
changes.
Altogether,
our
meta-map
provides
rich
resource
defining
microarchitectural
landscape
WAT
describes
associations
types
metabolic
states.
Science Translational Medicine,
Journal Year:
2023,
Volume and Issue:
15(723)
Published: Nov. 22, 2023
Obesity-associated
inflammation
is
a
systemic
process
that
affects
all
metabolic
organs.
Prominent
among
these
adipose
tissue,
where
cells
of
the
innate
and
adaptive
immune
system
are
markedly
changed
in
obesity,
implicating
range
processes
linking
memory
to
regulation.
Furthermore,
weight
loss
cycling
have
unexpected
effects
on
tissue
populations.
Here,
we
review
current
literature
roles
various
lean
obese
tissue.
Within
this
context,
discuss
pharmacological
nonpharmacological
approaches
obesity
treatment
their
impact
inflammation.
Cell Metabolism,
Journal Year:
2024,
Volume and Issue:
36(2), P. 278 - 300
Published: Jan. 5, 2024
The
risk
associated
with
multiple
cancers,
cardiovascular
disease,
diabetes,
and
all-cause
mortality
is
decreased
in
individuals
who
meet
the
current
recommendations
for
physical
activity.
Therefore,
regular
exercise
remains
a
cornerstone
prevention
treatment
of
non-communicable
diseases.
An
acute
bout
results
coordinated
interaction
between
tissues
to
increased
energy
demand
exercise.
Over
time,
metabolic
stress
each
individual
provides
basis
long-term
adaptations
across
tissues,
including
system,
skeletal
muscle,
adipose
tissue,
liver,
pancreas,
gut,
brain.
plethora
benefits
throughout
whole
body,
improved
cardiorespiratory
fitness,
function,
glycemic
control.
Overall,
we
summarize
exercise-induced
that
occur
within
how
they
converge
ultimately
improve
cardiometabolic
health.
