Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 20(4), P. 228 - 238
Published: Dec. 20, 2023
Language: Английский
Nature Medicine, Journal Year: 2023, Volume and Issue: 29(4), P. 963 - 972
Published: April 1, 2023
Language: Английский
Citations
66
Progress in Lipid Research, Journal Year: 2023, Volume and Issue: 91, P. 101235 - 101235
Published: May 15, 2023
Lipids play important roles in energy metabolism along with diverse aspects of biological membrane structure, signaling and other functions. Perturbations lipid are responsible for the development various pathologies comprising metabolic syndrome, obesity, type 2 diabetes. Accumulating evidence suggests that circadian oscillators, operative most cells our body, coordinate temporal homeostasis. In this review we summarize current knowledge on regulation digestion, absorption, transportation, biosynthesis, catabolism, storage. Specifically, focus molecular interactions between functional clockwork biosynthetic pathways major classes cholesterol, fatty acids, triacylglycerols, glycerophospholipids, glycosphingolipids, sphingomyelins. A growing body epidemiological studies associate a socially imposed misalignment common modern society incidence disorders, however disruption rhythms connection has only been recently revealed. Here, highlight recent unravel mechanistic link intracellular clocks, homeostasis diseases based animal models clock innovative translational humans. We also discuss perspectives manipulating oscillators as potentially powerful approach preventing managing disorders human patients.
Language: Английский
Citations
55
Sleep Medicine Reviews, Journal Year: 2024, Volume and Issue: 75, P. 101926 - 101926
Published: March 21, 2024
The number of individuals experiencing sleep loss has exponentially risen over the past decades. Extrapolation laboratory findings to real world suggests that females are more affected by extended wakefulness and circadian misalignment than males are. Therefore, long-term effects such as metabolism disorders likely be prevalent in males. Despite emerging evidence for sex differences key aspects sleep-wake regulation, much remains unknown, often underrepresented research. This brief communication is intended highlight 1) how systematically impinge on regulation humans, 2) factors modulate metabolism, 3) meaning these precision medicine. Ultimately, justify factoring when optimizing individually targeted interventions humans.
Language: Английский
Citations
36
Clocks & Sleep, Journal Year: 2023, Volume and Issue: 5(3), P. 507 - 535
Published: Sept. 6, 2023
Achieving synchronization between the central and peripheral body clocks is essential for ensuring optimal metabolic function. Meal timing an emerging field of research that investigates influence eating patterns on our circadian rhythm, metabolism, overall health. This narrative review examines relationship meal timing, clock genes, hormones, It analyzes existing literature experimental data to explore connection mealtime, rhythms, processes. The available evidence highlights importance aligning mealtime with body’s natural rhythms promote health prevent disorders. Specifically, studies show consuming meals later in day associated elevated prevalence disorders, while early time-restricted eating, such as having breakfast earlier dinner, improves levels glucose blood substrate oxidation. Circadian including cortisol melatonin, interact mealtimes play vital roles regulating Cortisol, aligned dawn diurnal mammals, activates energy reserves, stimulates appetite, influences gene expression, synchronizes clocks. Consuming during periods melatonin levels, specifically night, has been correlated potential implications tolerance. Understanding mechanisms synchronization, genetics, interactions chronotype, sleep duration, hormonal changes, provides valuable insights optimizing dietary strategies timing. knowledge contributes improved well-being by rhythm.
Language: Английский
Citations
39
Pharmacological Research, Journal Year: 2023, Volume and Issue: 196, P. 106925 - 106925
Published: Sept. 13, 2023
With changing lifestyles, non-alcoholic fatty liver disease (NAFLD) has become the most prevalent worldwide. A substantial increase in incidence, mortality, and associated burden of NAFLD-related advanced is expected. Currently, initial diagnosis NAFLD still based on ultrasound there no approved treatment method. Lipid-lowering drugs, vitamin supplementation, lifestyle improvement treatments are commonly used clinical practice. However, lipid-lowering drugs can produce poor patient compliance specific adverse effects. Therefore, exploration bio-diagnostic markers active lead compounds for development innovative urgently needed. More more studies have reported anti-NAFLD effects mechanisms natural products (NPs), which an important source new drug to treat due their high activity low side At present, berberine silymarin been by US FDA enter phase IV studies, demonstrating potential NPs against NAFLD. Studies found that regulation lipid metabolism, insulin resistance, oxidative stress, inflammation-related pathways may play roles process. continuous updating technical means scientific theories, in-depth research targets provide possibilities find drugs. As we know, FXR agonists, PPARα dual CCR2/5 inhibitors gradually coming stage Whether exert regulating these or some unknown remains be further studied. study reviewed targets. Some works discovery docking were also discussed. It hoped this review reference values non-invasive diagnostic clinic.
Language: Английский
Citations
28
Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(6), P. 1000 - 1007
Published: June 3, 2024
Language: Английский
Citations
14
Diabetes/Metabolism Research and Reviews, Journal Year: 2024, Volume and Issue: 40(1)
Published: Jan. 1, 2024
Abstract Obesity rates are increasing in almost all high‐ and low‐income countries, population‐based approaches necessary to reverse this trend. The current global efforts focused on identifying the root causes of obesity developing effective methods for early diagnosis, screening, treatment, long‐term management, both at an individual health system level. However, there is a relative lack options which means that strategies also needed. These involve conceptual shifts towards community‐ environment‐focused approaches. This review aimed provide evidence how environmental factors contribute risk reshaping cities can help slow down prevalence improve management.
Language: Английский
Citations
12
Diabetes/Metabolism Research and Reviews, Journal Year: 2024, Volume and Issue: 40(2)
Published: Feb. 1, 2024
Abstract Chrononutrition is a nutritional regimen that follows our biological clock, marked by the changes in metabolism occur during day. This includes distribution of energy, regularity and frequency meals, importance these factors for metabolic health. A growing body animal human evidence indicates timing food intake throughout day can have significant beneficial impact on health well‐being individuals. In particular, both meals been associated with obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, other chronic conditions. Today's busy lifestyle makes many people skip breakfast eat late at night. Eating night has shown to cause circadian misalignment, latter having negative weight control glucose metabolism. Additionally, some studies found relatively strong association between skipping insulin resistance, T2DM. Against backdrop escalating obesity T2DM rates, coupled recognized influence disease evolution control, this review aimed synthesize insights from epidemiological intervention interplay macronutrient consumption, reporting their
Language: Английский
Citations
12
iScience, Journal Year: 2024, Volume and Issue: 27(2), P. 109000 - 109000
Published: Jan. 26, 2024
Time-restricted eating (TRE) is an effective way to lose weight and improve metabolic health in animals. Yet whether how these benefits apply humans unclear. This systematic review meta-analysis examined the effect of TRE people with overweight obesity statuses. The results showed that led modest loss, lower waist circumference energy deficits. also improved body mass index, fat mass, lean systolic blood pressure, fasting glucose levels, insulin HbA1c%. Subgroup analysis demonstrated more improvements group than control under
Language: Английский
Citations
9
Cell Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Abstract Sleep deficiency is associated with obesity, but the mechanisms underlying this connection remain unclear. Here, we identify a sleep-inducible hypothalamic protein hormone in humans and mice that suppresses obesity. This cleaved from reticulocalbin-2 (RCN2), name it Raptin. Raptin release timed by circuit vasopressin-expressing neurons suprachiasmatic nucleus to RCN2-positive paraventricular nucleus. levels peak during sleep, which blunted sleep deficiency. binds glutamate metabotropic receptor 3 (GRM3) of hypothalamus stomach inhibit appetite gastric emptying, respectively. Raptin-GRM3 signaling mediates anorexigenic effects via PI3K-AKT signaling. Of note, verify connections between deficiencies sleeping state, impaired release, obesity patients Moreover, carrying an RCN2 nonsense variant present night eating syndrome These data define unique food intake prevents
Language: Английский
Citations
1