Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies DOI Creative Commons

Shuaiqi Wang,

Tong Huo,

Mingyang Lu

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 499 - 499

Published: March 27, 2025

Cellular senescence is an irreversible state of cell cycle arrest. Senescent cells (SCs) accumulate in the body with age and secrete harmful substances known as senescence-associated secretory phenotype (SASP), causing chronic inflammation; at same time, inflammation leads to a decrease immune system function, immunosenescence, which further accelerates aging process. immunosenescence are closely related variety diseases, including cardiovascular metabolic disorders, autoimmune neurodegenerative diseases. Studying mechanisms cellular developing targeted interventions crucial for improving function quality life elderly people. Here, we review series recent studies focusing on molecular regulation by system, latest advances basic clinical research senolytics. We summarize animal models research, well mechanisms, strategies, future directions from immunological perspective, hope laying foundation novel practical anti-aging therapies.

Language: Английский

Stem cell-derived extracellular vesicles as senotherapeutics DOI

Ekaterina Rudnitsky,

Alex Braiman,

Marina Wolfson

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102391 - 102391

Published: June 22, 2024

Language: Английский

Citations

7
Ginkgetin Alleviates Inflammation and Senescence by Targeting STING DOI Creative Commons
Yadan Liu, Jialin Ye,

Zisheng Fan

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 19, 2024

Abstract Ginkgo biloba extract is reported to have therapeutic effects on aging‐related disorders. However, the specific component responsible for this biological function and its mechanism of action remain largely unknown. This study finds that Ginkgetin, an active ingredient extract, can alleviate cellular senescence improve pathologies in multiple tissues aging mice. To reveal molecular Ginkgetin's anti‐aging effect, a graph convolutional network‐based drug “on‐target” pathway prediction algorithm employed. The results indicate cGAS‐STING may be potential target Ginkgetin. Subsequent cell biophysical data confirmed Ginkgetin directly binds carboxy‐terminal domain STING protein, thereby inhibiting activation signal transduction. Furthermore, vivo pharmacodynamic showed effectively alleviates systemic inflammation Trex1 −/− mice inhibits abnormally activated signaling mouse model. In summary, study, utilizing artificial intelligence combined with pharmacological methods, confirms serves as critical alleviating senescence. Importantly, elucidates underlying effect providing robust theoretical basis use.

Language: Английский

Citations

7
METFORMIN: FROM DIABETES TO CANCER TO PROLONGATION OF LIFE DOI Creative Commons
Cesare R. Sirtori,

Sofia Castiglione,

Chiara Pavanello

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107367 - 107367

Published: Aug. 25, 2024

The metformin molecule dates back to over a century, but its clinical use started in the '50s. Since then, diabetics has grown constantly, with 150 million users today. therapeutic profile also expanded, improved understanding of novel mechanisms. Metformin major activity on insulin resistance, by acting receptors and mitochondria, most likely activation adenosine monophosphate-activated kinase. These associated mechanisms lead significant lipid lowering body weight loss. An anti-cancer action come up recent years, partly dependent mitochondrial phosphatidylinositol 3-kinase resistance occurring some malignant tumors. potential raise life-length is object large ongoing studies several basic investigations. present review article will attempt investigate behind these diverse activities benefits. may act transcriptional histone modification, DNA methylation miRNAs. age-associated inflammation (inflammaging) occur via nuclear factor erythroid 2 related changes gut microbiota. A senolytic activity, leading reduction cells senescent secretory phenotype, be crucial lifespan prolongation as well ancillary properties diseases, such Parkinson's disease. Telomere respiratory 1 peroxisome gamma proliferator coactivator 1-alpha. Very observations severe neurological disorders, amyotrophic lateral sclerosis frontotemporal dementia, have raised considerable hope.

Language: Английский

Citations

5
Fecal Microbiota Transplantation, a tool to transfer healthy longevity DOI Creative Commons
Marta G. Novelle,

Beatriz Naranjo-Martínez,

Juan L López-Cánovas

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 103, P. 102585 - 102585

Published: Nov. 23, 2024

The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer longevity. Herein, we comprehensively review benefits microbial rejuvenation - FMT promote aging, with few studies documenting life length properties. This explores how preconditioning donors standard lifestyle pharmacological antiaging interventions reshape microbiome, resulting being also FMT-transferable. Finally, expose current clinical uses context therapy address challenges regulatory landscape, protocol standardization, health risks that require refinement effectively utilize elderly.

Language: Английский

Citations

5
Western diet-induced cognitive and metabolic dysfunctions in aged mice are prevented by rosmarinic acid in a sex-dependent fashion DOI Creative Commons
Letizia Giona, Chiara Musillo,

G. Cristofaro

et al.

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(10), P. 2236 - 2248

Published: Aug. 18, 2024

Unhealthy lifestyles, such as chronic consumption of a Western Diet (WD), have been associated with increased systemic inflammation and oxidative stress (OS), condition that may favour cognitive dysfunctions during aging. Polyphenols, rosmarinic acid (RA) buffer low-grade OS, characterizing the aging brain is sustained by WD, promoting healthspan. The aim this study was to evaluate ability RA prevent decline in mouse model WD-driven unhealthy gain knowledge on specific molecular pathways modulated within brain.

Language: Английский

Citations

4
Senescent endothelial cells: a potential target for diabetic retinopathy DOI Creative Commons

Ying-Lu Liao,

Yifan Fang,

Jiaxing Sun

et al.

Angiogenesis, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and relevant retinal diseases. Current therapeutic strategies on DR primarily focus antiangiogenic therapies, which particularly target vascular endothelial growth factor its related signaling transduction. However, these therapies still have limitations due to the intricate pathogenesis of DR. Emerging studies shown premature senescence cells (ECs) hyperglycemic environment involved disease process plays multiple roles at different stages. Moreover, surprising discoveries driven development senotherapeutics targeting senescent (SECs), present challenging but promising prospects treatment. In this review, we inducers mechanisms EC summarize current research advances SECs for Herein, highlight role played by key factors stages senescence, will be critical facilitating future innovative treatment

Language: Английский

Citations

4
Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+ DOI
Lena Elise Høyland,

Magali R. VanLinden,

Marc Niere

et al.

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(12), P. 2319 - 2337

Published: Dec. 13, 2024

Language: Английский

Citations

4
Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis DOI Creative Commons
Shizhen Lei, Yani Liu

Translational Vision Science & Technology, Journal Year: 2025, Volume and Issue: 14(1), P. 5 - 5

Published: Jan. 9, 2025

Purpose: Previous researches have suggested an important association between gut microbiota (GM) and vascular pathologies such as atherosclerosis. This study aimed to explore the 196 GM taxa retinal vein occlusion (RVO). Methods: used Mendelian randomization (MR), linkage disequilibrium score regression (LDSC), polygenic overlap analysis. Genome-wide (GWAS) data associated with was obtained from MiBioGen consortium, involving a large number of European-ancestry participants. GWAS RVO FinnGen consortium another that also involved Inverse-variance weighted primary approach for MR estimation. Moreover, LDSC analyses were performed evaluate genetic correlation RVO. Results: The results identified six taxa, including class Bacilli, order Lactobacillales, family Streptococcaceae, genus Clostridium innocuum group, Family XIII AD3011 Subdoligranulum development In addition, analysis supported Conclusions: Our findings confirmed RVO, thereby highlighting effects on health. Translational Relevance: may provide rationale developing GM-based strategies preventing onset

Language: Английский

Citations

0
Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species DOI Open Access
Man Zhu, Meng Ma,

Lunan Luo

et al.

Published: Jan. 22, 2025

DNA topoisomerases are essential molecular machines that manage topology in the cell and play important roles replication transcription. We find knocking down enzyme Topoisomerase Top2 or its mammalian homolog Top2b increases life span of S. cerevisiae , C. elegans mice. reduction also extends health mice alleviates pathologies aging multiple tissues. At cellular/molecular level, attenuates major hallmarks aging, such as cellular senescence, de-regulated nutrient sensing, epigenetic alteration, lysosomal biogenesis. observed significantly changes landscape various mouse tissues toward those young animals, differentially down-regulates genes with active promoter high expression. Our observations suggest confers longevity effect across species via a conserved mechanism, may be used novel therapeutic strategy for countering aging.

Language: Английский

Citations

0
Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species DOI Open Access
Man Zhu, Meng Ma,

Lunan Luo

et al.

Published: Jan. 22, 2025

DNA topoisomerases are essential molecular machines that manage topology in the cell and play important roles replication transcription. We find knocking down enzyme Topoisomerase Top2 or its mammalian homolog Top2b increases life span of S. cerevisiae , C. elegans mice. reduction also extends health mice alleviates pathologies aging multiple tissues. At cellular/molecular level, attenuates major hallmarks aging, such as cellular senescence, de-regulated nutrient sensing, epigenetic alteration, lysosomal biogenesis. observed significantly changes landscape various mouse tissues toward those young animals, differentially down-regulates genes with active promoter high expression. Our observations suggest confers longevity effect across species via a conserved mechanism, may be used novel therapeutic strategy for countering aging.

Language: Английский

Citations

0