Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 6, 2025
Neurodegenerative
diseases
including
Alzheimer's
and
Parkinson's
disease
are
age-related
disorders
which
severely
impact
quality
of
life
impose
significant
societal
burdens.
Cellular
senescence
is
a
critical
factor
in
these
disorders,
contributing
to
their
onset
progression
by
promoting
permanent
cell
cycle
arrest
reducing
cellular
function,
affecting
various
types
cells
brain.
Recent
advancements
regenerative
medicine
have
highlighted
"R3"
strategies-rejuvenation,
regeneration,
replacement-as
promising
therapeutic
approaches
for
neurodegeneration.
This
review
aims
critically
analyze
the
role
neurodegenerative
organizes
within
R3
paradigm.
Specifically,
we
examine
stem
therapy,
direct
lineage
reprogramming,
partial
reprogramming
context
R3,
emphasizing
how
interventions
mitigate
counteracting
aging-related
Ultimately,
this
seeks
provide
insights
into
complex
interplay
between
neurodegeneration
while
highlighting
promise
cell-based
strategies
address
debilitating
conditions.
Inflammation and Regeneration,
Journal Year:
2024,
Volume and Issue:
44(1)
Published: June 3, 2024
Abstract
Cellular
senescence
is
the
state
in
which
cells
undergo
irreversible
cell
cycle
arrest
and
acquire
diverse
phenotypes.
It
has
been
linked
to
chronic
inflammation
fibrosis
various
organs
as
well
individual
aging.
Therefore,
eliminating
senescent
emerged
a
potential
target
for
extending
healthy
lifespans.
plays
beneficial
role
many
biological
processes,
including
embryonic
development,
wound
healing,
tissue
regeneration,
mediated
by
activation
of
stem
cells.
comprehensive
understanding
cellular
senescence,
both
its
detrimental
effects,
critical
developing
safe
effective
treatment
strategies
This
review
provides
an
overview
pathological
roles
with
particular
focus
on
or
functions
among
roles.
Advanced Biology,
Journal Year:
2024,
Volume and Issue:
8(9)
Published: June 27, 2024
Abstract
Population
aging
has
increased
the
global
prevalence
of
aging‐related
diseases,
including
cancer,
sarcopenia,
neurological
disease,
arthritis,
and
heart
disease.
Understanding
aging,
a
fundamental
biological
process,
led
to
breakthroughs
in
several
fields.
Cellular
senescence,
evinced
by
flattened
cell
bodies,
vacuole
formation,
cytoplasmic
granules,
ubiquitously
plays
crucial
roles
tissue
remodeling,
embryogenesis,
wound
repair
as
well
cancer
therapy
aging.
The
lack
universal
biomarkers
for
detecting
quantifying
senescent
cells,
vitro
vivo,
constitutes
major
limitation.
applications
limitations
senescence
biomarkers,
senescence‐associated
β‐galactosidase
staining,
telomere
shortening,
cell‐cycle
arrest,
DNA
methylation,
secreted
phenotypes
are
discussed.
Furthermore,
explore
senotherapeutic
approaches
aging‐associated
diseases
cancer.
In
addition
conventional
this
review
highlighted
vitro,
disease
models
used
studies.
Further,
technologies
from
current
decade
multi‐omics
computational
methods
fields
also
discussed
review.
processes
using
cellular
can
enable
therapeutic
innovation
interventions
improve
quality
life
older
adults.
Neurotherapeutics,
Journal Year:
2025,
Volume and Issue:
22(3), P. e00519 - e00519
Published: Jan. 6, 2025
Cellular
senescence
is
a
cell
state
triggered
by
programmed
physiological
processes
or
cellular
stress
responses.
Stress-induced
senescent
cells
often
acquire
pathogenic
traits,
including
toxic
secretome
and
resistance
to
apoptosis.
When
form
faster
than
they
are
cleared
the
immune
system,
accumulate
in
tissues
throughout
body
contribute
age-related
diseases,
neurodegeneration.
This
review
highlights
evidence
of
brain
their
role
Alzheimer's
disease
(AD),
leading
cause
dementia
older
adults.
We
also
discuss
progress
challenges
senotherapies,
pharmacological
strategies
clear
mitigate
effects,
which
hold
promise
as
interventions
for
AD
related
dementias
(ADRD).
Seminars in Cancer Biology,
Journal Year:
2024,
Volume and Issue:
101, P. 58 - 73
Published: May 27, 2024
Cancer
is
daunting
pathology
with
remarkable
breadth
and
scope,
spanning
genetics,
epigenetics,
proteomics,
metalobomics
cell
biology.
Cellular
senescence
represents
a
stress-induced
essentially
irreversible
fate
associated
aging
various
age-related
diseases,
including
malignancies.
Senescent
cells
are
characterized
of
morphologic
alterations
metabolic
reprogramming,
develop
highly
active
secretome
termed
as
the
senescence-associated
secretory
phenotype
(SASP).
Since
first
discovery,
has
been
understood
an
important
barrier
to
tumor
progression,
its
induction
in
pre-neoplastic
limits
carcinogenesis.
Paradoxically,
senescent
arising
microenvironment
(TME)
contribute
augmented
therapeutic
resistance.
In
this
article,
we
define
typical
forms
commonly
observed
within
TME
how
functionally
remodel
their
surrounding
niche,
affect
immune
responses
promote
cancer
evolution.
Furthermore,
highlight
recently
emerging
pipelines
senotherapies
particularly
senolytics,
which
can
selectively
deplete
from
affected
organs
vivo
impede
progression
by
restoring
securing
anticancer
efficacies.
Together,
co-targeting
normal
but
counterparts
holds
potential
achieve
increased
benefits
restrained
disease
relapse
future
clinical
oncology.
Cancer Cell International,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 28, 2024
Breast
cancer
has
become
the
malignant
tumor
with
first
incidence
and
second
mortality
among
female
cancers.
Most
breast
cancers
belong
to
luminal-type
HER2-positive
cancer.
These
cells
all
have
different
driving
genes,
which
constantly
promote
proliferation
metastasis
of
cells.
Signal
transducer
activator
transcription
3
(STAT3)
is
an
important
cancer-related
gene,
can
progress
It
been
proved
in
clinical
basic
research
that
over-expressed
constitutively
activated
STAT3
involved
progress,
proliferation,
chemotherapy
resistance
key
target
cancer,
impact
on
curative
effect
related
treatments.
In
activation
will
change
spatial
position
protein
cause
phenotypic
changes
current
research,
small
molecule
inhibitors
by
targeting
effectively
treat
enhance
efficacy
level
treatment
methods
for
