Orthopedic Reviews,
Journal Year:
2025,
Volume and Issue:
17
Published: March 31, 2025
Musculoskeletal
injuries
and
degenerative
conditions
necessitate
advanced
regenerative
solutions.
Tissue
engineering
has
emerged
as
a
pivotal
field
in
orthopedic
care,
particularly
vascularized
bone
cartilage
regeneration.
This
narrative
review
examines
the
latest
advancements
vascular
tissue
engineering,
including
scaffold
design,
cell-based
techniques,
growth
factor
delivery.
A
comprehensive
literature
search
was
conducted
using
PubMed,
ScienceDirect,
Google
Scholar,
focusing
on
innovations
challenges
field.
Vascularized
grafts
(VBGs)
outperform
non-vascularized
counterparts
promoting
healing
integration.
Advances
materials,
such
smart
scaffolds
hybrid
biomaterials,
enhance
osteogenesis
angiogenesis.
Cellular
therapies,
utilizing
mesenchymal
stem
cells
induced
pluripotent
cells,
synergistically
improve
vascularization
Growth
factors
like
VEGF
morphogenic
protein
(BMP-2),
integrated
with
innovative
delivery
systems,
enable
sustained
angiogenic
stimulation
While
significant
strides
have
been
made,
persist
achieving
full
integration
replicating
native
architecture.
Innovations
technology
surgery
techniques
hold
promise
for
transforming
improving
patient
outcomes.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(12)
Published: Jan. 25, 2024
3D
stem
cell
spheroids
have
immense
potential
for
various
tissue
engineering
applications.
However,
current
spheroid
fabrication
techniques
encounter
viability
issues
due
to
limited
oxygen
access
cells
trapped
within
the
core,
as
well
nonspecific
differentiation
complicated
environment
following
transplantation.
In
this
study,
functional
are
developed
using
mesenchymal
with
2D
hetero-nanostructures
(HNSs)
composed
of
single-stranded
DNA
(ssDNA)
binding
carbon
nanotubes
(sdCNTs)
and
gelatin-bind
black
phosphorus
nanosheets
(gBPNSs).
An
osteogenic
molecule,
dexamethasone
(DEX),
is
further
loaded
fabricate
an
sdCNTgBP-DEX
HNS.
This
approach
aims
establish
a
multifunctional
cell-inductive
improved
transportation
through
hollow
nanotubes,
stimulated
growth
by
phosphate
ions
supplied
from
BP
oxidation,
in
situ
immunoregulation,
osteogenesis
induction
DEX
molecules
after
implantation.
Initial
transplantation
rat
calvarial
bone
defect
shows
vivo
macrophage
shifts
M2
phenotype,
leading
pro-healing
microenvironment
regeneration.
Prolonged
implantation
demonstrates
outstanding
neovascularization,
osteointegration,
new
Therefore,
these
engineered
hold
great
promise
repair
they
allow
delivery
provide
immunoregulative
signals
all-in-one
construct.
Results in Engineering,
Journal Year:
2024,
Volume and Issue:
22, P. 102046 - 102046
Published: March 22, 2024
Bone
tissue
engineering
(BTE)
holds
promise
for
treating
bone
defects,
and
3D-printed
porous
scaffolds
are
pivotal
regeneration.
This
study
explores
the
impact
of
material
extrusion
3D
printing
(ME3DP)
process
parameters
(i.e.,
layer
height
temperature)
on
made
polyetherimide
(PEI)
BTE.
The
intricate
relationships
shaping
scaffold
dimensional
accuracy,
residual
stresses,
warpage
tendencies
were
unveiled
using
comprehensive
numerical
simulations.
Our
findings
reveal
that
higher
heights
enhance
stability,
especially
at
lower
temperatures,
reducing
maximum
displacements.
Consequently,
lead
to
critical
values.
insight
is
instrumental
in
optimizing
process,
vital
precise
net
shape
BTE
applications.
Furthermore,
stresses
also
revealed
a
correlation
between
temperatures
increased
stresses.
These
emphasize
necessity
balancing
flow,
temperature,
quality.
Therefore,
right
balance
precision
mechanical
stability
producing
high-quality
meet
requirements.
Orthopedic Reviews,
Journal Year:
2025,
Volume and Issue:
17
Published: March 31, 2025
Musculoskeletal
injuries
and
degenerative
conditions
necessitate
advanced
regenerative
solutions.
Tissue
engineering
has
emerged
as
a
pivotal
field
in
orthopedic
care,
particularly
vascularized
bone
cartilage
regeneration.
This
narrative
review
examines
the
latest
advancements
vascular
tissue
engineering,
including
scaffold
design,
cell-based
techniques,
growth
factor
delivery.
A
comprehensive
literature
search
was
conducted
using
PubMed,
ScienceDirect,
Google
Scholar,
focusing
on
innovations
challenges
field.
Vascularized
grafts
(VBGs)
outperform
non-vascularized
counterparts
promoting
healing
integration.
Advances
materials,
such
smart
scaffolds
hybrid
biomaterials,
enhance
osteogenesis
angiogenesis.
Cellular
therapies,
utilizing
mesenchymal
stem
cells
induced
pluripotent
cells,
synergistically
improve
vascularization
Growth
factors
like
VEGF
morphogenic
protein
(BMP-2),
integrated
with
innovative
delivery
systems,
enable
sustained
angiogenic
stimulation
While
significant
strides
have
been
made,
persist
achieving
full
integration
replicating
native
architecture.
Innovations
technology
surgery
techniques
hold
promise
for
transforming
improving
patient
outcomes.
