Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
28(4), P. 978 - 1002
Published: March 15, 2024
Despite
the
reported
successes
and
advantages
involving
use
of
amphiphilic
surfactants,
most
notably
TPGS-750-M,
to
enable
a
multitude
synthetic
transformations
be
conducted
in
water,
implementation
this
methodology
within
pharmaceutical
industry
has
been
relatively
limited.
In
paper,
we
will
disclose
key
results
learnings
from
multicompany
collaboration
focused
on
reproducibility
study
some
commonly
used
reaction
types
industry,
specifically
amidation,
SNAr,
nitro
reduction,
reductive
amination,
multiple
Pd-catalyzed
water.
The
presentation
not
just
originally
TPGS-750-M
conditions
but
also
under
water-only
control
with
three
different
as
well
both
small
(i.e.,
≤500
mg)
mid
(∼10
g)
scales.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
12(12), P. 4237 - 4266
Published: Jan. 1, 2021
A
review
presenting
water
as
the
logical
reaction
medium
for
future
of
organic
chemistry.
discussion
is
offered
that
covers
both
"on
water"
and
"in
phenomena,
how
playing
unique
roles
in
each,
specifically
with
regard
to
its
use
synthesis.
Chemistry - A European Journal,
Journal Year:
2018,
Volume and Issue:
24(26), P. 6672 - 6695
Published: Feb. 21, 2018
Recent
developments
over
the
past
few
years
in
aqueous
micellar
catalysis
are
discussed.
Applications
to
problems
synthesis
highlighted,
enabled
by
use
of
surfactants
that
self-aggregate
water
into
micelles
as
nanoreactors.
These
include
amphiphiles
have
been
available
for
some
time,
well
those
newly
designed.
Reactions
catalyzed
transition
metals,
including
Pd,
Cu,
Rh,
and
Au,
particular
focus.
Nature Communications,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: May 15, 2019
Abstract
Previous
studies
have
shown
that
aqueous
solutions
of
designer
surfactants
enable
a
wide
variety
valuable
transformations
in
synthetic
organic
chemistry.
Since
reactions
take
place
within
the
inner
hydrophobic
cores
these
tailor-made
nanoreactors,
and
products
made
therein
are
dynamic
exchange
between
micelles
through
water,
opportunities
exist
to
use
enzymes
effect
secondary
processes.
Herein
we
report
ketone-containing
products,
formed
via
initial
transition
metal-catalyzed
based
on
Pd,
Cu,
Rh,
Fe
Au,
can
be
followed
same
pot
by
enzymatic
reductions
mediated
alcohol
dehydrogenases.
Most
noteworthy
is
finding
nanomicelles
present
water
appear
function
not
only
as
medium
for
both
chemo-
bio-catalysis,
but
reservoir
substrates,
catalysts,
decreasing
noncompetitive
enzyme
inhibition.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(5), P. 1704 - 1728
Published: Jan. 1, 2023
Publication
of
the
E
Factor
drew
attention
to
problem
waste
in
chemicals
manufacture.
Thirty
yeas
later
it
is
abundantly
clear
that
underlying
cause
global
environmental
problems,
from
climate
change
plastic
pollution.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(7), P. 4266 - 4278
Published: Feb. 8, 2023
Savie
is
a
biodegradable
surfactant
derived
from
vitamin
E
and
polysarcosine
(PSar)
developed
for
use
in
organic
synthesis
recyclable
water.
This
includes
homogeneous
catalysis
(including
examples
employing
only
ppm
levels
of
catalyst),
heterogeneous
catalysis,
biocatalytic
transformations,
including
multistep
chemoenzymatic
sequence.
Use
frequently
leads
to
significantly
higher
yields
than
do
conventional
surfactants,
while
obviating
the
need
waste-generating
solvents.
ChemCatChem,
Journal Year:
2019,
Volume and Issue:
11(9), P. 2226 - 2242
Published: Jan. 24, 2019
The
biological
potency
of
natural
products
has
been
exploited
for
decades.
Their
inherent
structural
complexity
and
diversity
might
hold
the
key
to
efficiently
address
urgent
need
development
novel
pharmaceuticals.
At
same
time,
it
is
that
very
complexity,
which
impedes
necessary
chemical
modifications
such
as
diversification,
improve
effectiveness
drug.
For
this
purpose,
Cytochrome
P450
enzymes,
possess
unique
abilities
activate
inert
sp
