Mechanisms underlying gut microbiota–host interactions in insects

Journal of Experimental Biology, Journal Year: 2021, Volume and Issue: 224(2)

Published: Jan. 15, 2021

ABSTRACT Insects are the most diverse group of animals and colonize almost all environments on our planet. This diversity is reflected in structure function microbial communities inhabiting insect digestive system. As mammals, gut microbiota insects can have important symbiotic functions, complementing host nutrition, facilitating dietary breakdown or providing protection against pathogens. There an increasing number models that experimentally tractable, mechanistic studies microbiota–host interactions. In this Review, we will summarize recent findings advanced understanding molecular mechanisms underlying symbiosis between their microbiota. We open article with a general introduction to then turn towards discussion particular processes governing colonization environment as well beneficial roles mediated by The Review highlights that, although active field research implications for fundamental applied science, still early stage mechanisms. However, expanding capability culture microbiomes manipulate microbe–host interactions promises new insights from symbioses.

Language: Английский

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Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(7), P. 944 - 960.e8

Published: June 1, 2022

Language: Английский

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Characterization of Apis mellifera Gastrointestinal Microbiota and Lactic Acid Bacteria for Honeybee Protection—A Review

Cells, Journal Year: 2021, Volume and Issue: 10(3), P. 701 - 701

Published: March 22, 2021

Numerous honeybee (Apis mellifera) products, such as honey, propolis, and bee venom, are used in traditional medicine to prevent illness promote healing. Therefore, this insect has a huge impact on humans’ way of life the environment. While population A. mellifera is large, there concern that widespread commercialization beekeeping, combined with environmental pollution action pathogens, caused significant problems for health populations. One strategies preserve welfare honeybees better understand protect their natural microbiota. This paper provides unique overview latest research features functioning mellifera. Honeybee microbiome analysis focuses both function numerous factors affecting it. In addition, we present characteristics lactic acid bacteria (LAB) an important part gut community special beneficial activities health. The idea probiotics promising tool improve widely discussed. Knowledge microbiota opportunity create broad strategy vitality, including development modern probiotic preparations use instead conventional antibiotics, environmentally friendly biocides, biological control agents.

Language: Английский

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Microbiota-brain interactions: Moving toward mechanisms in model organisms

Neuron, Journal Year: 2021, Volume and Issue: 109(24), P. 3930 - 3953

Published: Oct. 16, 2021

Language: Английский

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The gut microbiota of bumblebees

Insectes Sociaux, Journal Year: 2021, Volume and Issue: 68(4), P. 287 - 301

Published: Sept. 29, 2021

Language: Английский

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Gut microbiome drives individual memory variation in bumblebees

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Nov. 25, 2021

The potential of the gut microbiome as a driver individual cognitive differences in natural populations animals remains unexplored. Here, using metagenomic sequencing bumblebee hindguts, we find positive correlation between abundance Lactobacillus Firm-5 cluster and memory retention on visual discrimination task. Supplementation with species apis, but not other non-Firm-5 bacterial species, enhances bees' memory. Untargeted metabolomics after L. apis supplementation show increased LPA (14:0) glycerophospholipid haemolymph. Oral administration increases long-term significantly. Based our findings metagenomic/metabolomic analyses, propose molecular pathway for this gut-brain interaction. Our results provide insights into proximate ultimate causes populations.

Language: Английский

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The gut microbiota affects the social network of honeybees

Nature Ecology & Evolution, Journal Year: 2022, Volume and Issue: 6(10), P. 1471 - 1479

Published: Aug. 22, 2022

Language: Английский

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Delivery mechanism can enhance probiotic activity against honey bee pathogens

The ISME Journal, Journal Year: 2023, Volume and Issue: 17(9), P. 1382 - 1395

Published: June 14, 2023

Managed honey bee (Apis mellifera) populations play a crucial role in supporting pollination of food crops but are facing unsustainable colony losses, largely due to rampant disease spread within agricultural environments. While mounting evidence suggests that select lactobacilli strains (some being natural symbionts bees) can protect against multiple infections, there has been limited validation at the field-level and few methods exist for applying viable microorganisms hive. Here, we compare how two different delivery systems-standard pollen patty infusion novel spray-based formulation-affect supplementation three-strain consortium (LX3). Hives pathogen-dense region California supplemented 4 weeks then monitored over 20-week period health outcomes. Results show both facilitate uptake LX3 adult bees, although do not colonize long-term. Despite this, treatments induce transcriptional immune responses leading sustained decreases many opportunistic bacterial fungal pathogens, as well selective enrichment core including Bombilactobacillus, Bifidobacterium, Lactobacillus, Bartonella spp. These changes ultimately associated with greater brood production growth relative vehicle controls, no apparent trade-offs ectoparasitic Varroa mite burdens. Furthermore, spray-LX3 exerts potent activities Ascosphaera apis (a deadly pathogen) likely stemming from in-hive dispersal differences, whereas patty-LX3 promotes synergistic development via unique nutritional benefits. findings provide foundational basis probiotic application apiculture collectively highlight importance considering method management strategies.

Language: Английский

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Neonicotinoids in the agroecosystem: In-field long-term assessment on honeybee colony strength and microbiome

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 762, P. 144116 - 144116

Published: Dec. 16, 2020

Language: Английский

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Honey bee genetics shape the strain-level structure of gut microbiota in social transmission

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: Nov. 17, 2021

Abstract Background Honey bee gut microbiota transmitted via social interactions are beneficial to the host health. Although microbial community is relatively stable, individual variations and high strain-level diversity have been detected across honey bees. structure influenced by environmental factors, heritability of members contribution genetics remains elusive. Considering bees within a colony not readily genetically identical due polyandry queen, we hypothesize that can be shaped genetics. Results We used shotgun metagenomics simultaneously profile genotypes from hives four different subspecies. Gut composition more distant between at both phylotype- “sequence-discrete population” levels. then performed successive passaging experiment colonies hybrid generated artificial insemination, which revealed dramatically shifts batches during transmission. Specifically, strains phylotype Snodgrassella alvi preferentially selected varied hosts, hosts show remarkably biased distribution single-nucleotide polymorphism in Type IV pili loci. Genome-wide association analysis identified relative abundance cluster Bifidobacterium associated with glutamate receptor gene specifically expressed brain. Finally, mono-colonization specific polysaccharide utilization locus impacts alternative splicing gluR-B gene, an increased GABA level Conclusions Our results indicated influence suggest gut-brain connection implicated bacterial strain preference. extensively as model organism for behaviors, genetics, microbiome. Further identification genetic function shaping force will advance our understanding host-microbe interactions.

Language: Английский

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