Polymers,
Journal Year:
2022,
Volume and Issue:
14(5), P. 993 - 993
Published: Feb. 28, 2022
Over
recent
decades,
poly(lactic-co-glycolic
acid)
(PLGA)
based
nano-
and
micro-
drug
delivery
vehicles
have
been
rapidly
developed
since
PLGA
was
approved
by
the
Food
Drug
Administration
(FDA).
Common
factors
that
influence
particle
properties
extensively
studied
researchers,
such
as
size,
polydispersity
index
(PDI),
surface
morphology,
zeta
potential,
loading
efficiency.
These
all
found
to
be
key
for
determining
release
kinetics
of
particles.
For
applications
behavior
is
a
critical
property,
systems
are
still
plagued
with
issue
burst
when
large
portion
suddenly
released
from
rather
than
controlled
particles
designed
for.
Other
can
play
role
in
behavior,
glass
transition
temperature
(Tg).
The
Tg,
however,
an
underreported
property
current
systems.
This
review
summarizes
basic
knowledge
particles,
effect
Tg
on
presents
awareness
applications.
Frontiers in Pharmacology,
Journal Year:
2018,
Volume and Issue:
9
Published: Nov. 2, 2018
Nanomedicines
can
be
used
for
a
variety
of
cancer
therapies
including
tumor-targeted
drug
delivery,
hyperthermia,
and
photodynamic
therapy.
Poly
(lactic-co-glycolic
acid)
(PLGA)-based
materials
are
frequently
in
such
setups.
This
review
article
gives
an
overview
the
properties
previously
reported
PLGA
nanoparticles
(NPs),
their
behavior
biological
systems,
use
Strategies
emphasized
to
target
NPs
tumor
site
passively
actively.
Furthermore,
combination
introduced
that
enhance
accumulation
and,
thereby,
therapeutic
efficacy.
In
this
context,
huge
number
reports
on
as
delivery
systems
treatment
highlight
potential
carriers
therapeutics
encourage
further
translational
research.
Frontiers in Pharmacology,
Journal Year:
2021,
Volume and Issue:
12
Published: Feb. 3, 2021
Advances
in
nanotechnology
have
favored
the
development
of
novel
colloidal
formulations
able
to
modulate
pharmacological
and
biopharmaceutical
properties
drugs.
The
peculiar
physico-chemical
technological
nanomaterial-based
therapeutics
allowed
for
several
successful
applications
treatment
cancer.
size,
shape,
charge
patterning
nanoscale
therapeutic
molecules
are
parameters
that
need
be
investigated
modulated
order
promote
optimize
cell
tissue
interaction.
In
this
review,
use
polymeric
nanoparticles
as
drug
delivery
systems
anticancer
compounds,
their
ability
efficiently
localized
specific
tumor
tissues
been
described.
nanoencapsulation
antitumor
active
compounds
is
a
promising
approach
improve
efficacy
various
treatments.
Journal of Biomedical Science,
Journal Year:
2018,
Volume and Issue:
25(1)
Published: Dec. 1, 2018
The
nervous
system
is
a
crucial
component
of
the
body
and
damages
to
this
system,
either
by
injury
or
disease,
can
result
in
serious
potentially
lethal
consequences.
Restoring
damaged
great
challenge
due
complex
physiology
limited
regenerative
capacity.Polymers,
synthetic
natural
origin,
have
been
extensively
evaluated
as
solution
for
restoring
functions
neural
tissues.
Polymers
offer
wide
range
versatility,
particular
regarding
shape
mechanical
characteristics,
their
biocompatibility
unmatched
other
biomaterials,
such
metals
ceramics.
Several
studies
shown
that
polymers
be
shaped
into
suitable
support
structures,
including
nerve
conduits,
scaffolds,
electrospun
matrices,
capable
improving
regeneration
In
general,
advantage
better
bioactivity,
while
non-natural
properties
structural
stability.
Often,
combinations
two
allow
development
polymeric
conduits
able
mimic
native
physiological
environment
healthy
tissues
and,
consequently,
regulate
cell
behaviour
injured
tissues.Currently,
most
tissue
engineering
applications
are
pre-clinical
study,
use
central
however
collagen
polymer
aimed
at
peripheral
nerves
already
successfully
tested
clinical
trials.This
review
highlights
different
types
used
advantages
disadvantages
regeneration.
Bioactive Materials,
Journal Year:
2020,
Volume and Issue:
6(2), P. 346 - 360
Published: Aug. 29, 2020
Research
and
development
of
the
ideal
artificial
bone-substitute
materials
to
replace
autologous
allogeneic
bones
for
repairing
bone
defects
is
still
a
challenge
in
clinical
orthopedics.
Recently,
poly(lactic-co-glycolic
acid)
(PLGA)-based
are
attracting
increasing
attention
as
benefit
their
suitable
biocompatibility,
degradability,
mechanical
properties,
capabilities
promote
regeneration.
In
this
article,
we
comprehensively
review
made
from
PLGA
or
composites
other
organic
inorganic
substances,
elaborate
on
applications
regeneration
with
without
bioactive
factors,
prospect
challenges
opportunities
Advanced Healthcare Materials,
Journal Year:
2017,
Volume and Issue:
7(1)
Published: Nov. 24, 2017
Abstract
Poly(lactic‐
co
‐glycolic)
acid
(PLGA)
is
one
of
the
most
versatile
biomedical
polymers,
already
approved
by
regulatory
authorities
to
be
used
in
human
research
and
clinics.
Due
its
valuable
characteristics,
PLGA
can
tailored
acquire
desirable
features
for
control
bioactive
payload
or
scaffold
matrix.
Moreover,
chemical
modification
with
other
polymers
bioconjugation
molecules
may
render
functional
properties
that
make
it
Holy
Grail
among
synthetic
applied
field.
In
this
review,
physical–chemical
PLGA,
synthesis,
degradation,
conjugation
are
revised
detail,
as
well
applications
drug
delivery
regeneration
fields.
A
particular
focus
given
successful
examples
products
on
market
at
late
stages
trials,
reinforcing
potential
polymer
Acta Biomaterialia,
Journal Year:
2018,
Volume and Issue:
73, P. 38 - 51
Published: April 11, 2018
Nano-
and
microparticles
have
increasingly
widespread
applications
in
nanomedicine,
ranging
from
drug
delivery
to
imaging.
Poly(lactic-co-glycolic
acid)
(PLGA)
particles
are
the
most
widely-applied
type
of
due
their
biocompatibility
biodegradability.
Here,
we
discuss
preparation
PLGA
particles,
various
modifications
tailor
for
biological
systems.
We
highlight
new
approaches,
including
microfluidics
PRINT
method,
resulting
novel
or
responsive
properties,
such
as
Janus
upconversion
particles.
Finally,
describe
how
methods
can-
should-be
adapted
properties
desired
biomedical
application.
Our
aim
is
enable
researchers
who
work
with
better
appreciate
effects
selected
procedure
on
final
its
implications.Nanoparticles
important
field
biomedicine.
Particles
made
polymers
spotlight,
biodegradability,
biocompatibility,
versatility.
In
this
review,
range
formulation
techniques,
manipulations,
poly(lactic-co-glycolic
a
researcher
effectively
select
design
optimal
techniques
particle
synthesis
impact
possible
applications.
focus
recent
developments
that
emerged
over
past
years.
Overall,
show
chemistry
can
be
solve
pressing
needs.
AAPS PharmSciTech,
Journal Year:
2019,
Volume and Issue:
20(5)
Published: May 20, 2019
Protein
and
peptide
drugs
have
many
advantages,
such
as
high
bioactivity
specificity,
strong
solubility,
low
toxicity.
Therefore,
the
strategies
for
improving
bioavailability
of
protein
peptides
are
reviewed,
including
chemical
modification
nanocarriers,
absorption
enhancers,
mucous
adhesion
systems.
The
status,
disadvantages
various
systematically
analyzed.
systematic
personalized
design
factors
affecting
release
based
on
nanoparticles
is
pointed
out.
It
expected
to
a
oral
delivery
system
that
can
be
applied
in
clinic.
Nanomaterials,
Journal Year:
2020,
Volume and Issue:
10(4), P. 656 - 656
Published: April 1, 2020
Nanomedicine
is
a
field
of
science
that
uses
nanoscale
materials
for
the
diagnosis
and
treatment
human
disease.
It
has
emerged
as
an
important
aspect
therapeutics,
but
at
same
time,
also
raises
concerns
regarding
safety
nanomaterials
involved.
Recent
applications
functionalized
biodegradable
have
significantly
improved
profile
nanomedicine.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: June 7, 2021
Abstract
Over
the
past
decades,
great
interest
has
been
given
to
biomimetic
nanoparticles
(BNPs)
since
rise
of
targeted
drug
delivery
systems
and
nanotechnology.
Biological
vectors
including
cell
membranes,
extracellular
vesicles
(EVs),
viruses
are
considered
promising
candidates
for
owing
their
biocompatibility
biodegradability.
BNPs,
integration
biological
functional
agents,
anticipated
load
cargos
or
camouflage
synthetic
achieve
delivery.
Despite
excellent
intrinsic
properties,
natural
deliberately
modified
endow
multiple
functions
such
as
good
permeability,
improved
loading
capability,
high
specificity.
Through
structural
modification
transformation
vectors,
they
pervasively
utilized
more
effective
vehicles
that
can
deliver
contrast
chemotherapy
drugs,
nucleic
acids,
genes
target
sites
refractory
disease
therapy.
This
review
summarizes
recent
advances
in
based
on
EVs,
viruses,
highlighting
potential
applications
BNPs
fields
biomedical
imaging
therapy
industry,
well
discussing
possibility
clinical
translation
exploitation
trend
these
BNPs.
