Investigating Nanomaterials for Improved Barrier Properties in Food Packaging DOI Open Access
Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(2)

Published: Jan. 13, 2025

This review examines the potential of nanomaterials in revolutionizing food packaging, focusing on their role enhancing barrier properties and extending shelf life packaged foods. Traditional packaging materials often fall short effectively protecting against oxygen, moisture, UV light, resulting diminished quality shorter life. Nanomaterials, including nanoclays, metal oxide nanoparticles (e.g., ZnO, TiO₂), carbon-based graphene, carbon nanotubes), biodegradable options like cellulose nanocrystals, have emerged as promising solutions. These offer exceptional gas moisture properties, antimicrobial effects, protection capabilities. The provides an in-depth exploration various nanomaterials, highlighting distinctive mechanisms; such tortuosity which enhance performance by limiting permeability. It also discusses recent advancements integrating into both flexible rigid systems, well active intelligent that employs nanosensors for real-time monitoring freshness spoilage. Despite potential, challenges toxicity concerns, environmental impacts, economic constraints to large-scale adoption are addressed. emphasizes need future research dual-function can simultaneously improve enable sensing. innovations could transform technologies, promoting enhanced safety sustainability.

Language: Английский

Biopolymer: A Sustainable Material for Food and Medical Applications DOI Open Access
Jaya Baranwal, Brajesh Barse, Antonella Fais

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(5), P. 983 - 983

Published: Feb. 28, 2022

Biopolymers are a leading class of functional material suitable for high-value applications and great interest to researchers professionals across various disciplines. Interdisciplinary research is important understand the basic applied aspects biopolymers address several complex problems associated with good health well-being. To reduce environmental impact dependence on fossil fuels, lot effort has gone into replacing synthetic polymers biodegradable materials, especially those derived from natural resources. In this regard, many types or have been developed meet needs ever-expanding applications. These currently used in food expanding their use pharmaceutical medical industries due unique properties. This review focuses uses industry provides future outlook biopolymer industry.

Language: Английский

Citations

459

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors DOI Creative Commons
Agnese Gagliardi, Elena Giuliano, Eeda Venkateswararao

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Feb. 3, 2021

Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate pharmacological and biopharmaceutical properties drugs. The peculiar physico-chemical technological nanomaterial-based therapeutics allowed for several successful applications treatment cancer. size, shape, charge patterning nanoscale therapeutic molecules are parameters that need be investigated modulated order promote optimize cell tissue interaction. In this review, use polymeric nanoparticles as drug delivery systems anticancer compounds, their ability efficiently localized specific tumor tissues been described. nanoencapsulation antitumor active compounds is a promising approach improve efficacy various treatments.

Language: Английский

Citations

405

Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue Engineering, Antimicrobial, and Agro-Food Applications DOI Creative Commons
Vancha Harish, Devesh Tewari,

Manish Gaur

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(3), P. 457 - 457

Published: Jan. 28, 2022

In the last few decades, vast potential of nanomaterials for biomedical and healthcare applications has been extensively investigated. Several case studies demonstrated that can offer solutions to current challenges raw materials in fields. This review describes different nanoparticles nanostructured material synthesis approaches presents some emerging biomedical, healthcare, agro-food applications. focuses on various nanomaterial types (e.g., spherical, nanorods, nanotubes, nanosheets, nanofibers, core-shell, mesoporous) be synthesized from their bioimaging, biosensing, drug delivery, tissue engineering, antimicrobial, agro-foods. Depending morphology size, aspect ratio, geometry, porosity), used as formulation modifiers, moisturizers, nanofillers, additives, membranes, films. As toxicological assessment depends sizes morphologies, stringent regulation is needed testing efficient dosages. The perspectives an industrial breakthrough are related optimization production processing conditions.

Language: Английский

Citations

379

Drug release study of the chitosan-based nanoparticles DOI Creative Commons
Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin

et al.

Heliyon, Journal Year: 2021, Volume and Issue: 8(1), P. e08674 - e08674

Published: Dec. 24, 2021

Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted delivery, and controlled release. Chitosan-based nanoparticles (CSNPs) are employed as imaging delivering the particular sites in regulated manner. Drug release is an important factor ensuring high reproducibility, stability, quality control of CSNPs, scientific-based for developing CSNPs. Several factors influence from composition, composition ratio, ingredient interactions, preparation methods. Early, CSNPs were used improving solubility, pharmacokinetics, pharmacotherapeutics properties. Chitosan has developed toward system by exploring positively charged properties modifiable functional groups. Various modifications polymer backbone, charge, or groups will undoubtedly affect The significant on its therapeutic actions. Our review's objective was summarize discuss relationship between modification kinetics model. Kinetic models help describe rate, leading increased efficiency, accuracy, safety dose, optimizing device's design, evaluating improvement patient compatibility. In conclusion, almost all showed bi-phasic release, initial burst time followed manner achieving expected stimuli external can be applied. promising technique systems.

Language: Английский

Citations

310

Clinical translation of nanomedicines: Challenges, opportunities, and keys DOI
Mahmoud A. Younis, Hesham M. Tawfeek, Ahmed A. H. Abdellatif

et al.

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 181, P. 114083 - 114083

Published: Dec. 17, 2021

Language: Английский

Citations

206

Frontiers in the treatment of glioblastoma: Past, present and emerging DOI
Taskeen Iqbal Janjua,

Prarthana Rewatkar,

Aria Ahmed-Cox

et al.

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 171, P. 108 - 138

Published: Jan. 22, 2021

Language: Английский

Citations

197

The ancillary effects of nanoparticles and their implications for nanomedicine DOI Open Access

Evan P. Stater,

Ali Yasin Sonay,

Cassidy Hart

et al.

Nature Nanotechnology, Journal Year: 2021, Volume and Issue: 16(11), P. 1180 - 1194

Published: Nov. 1, 2021

Language: Английский

Citations

177

Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery DOI Creative Commons
Son H. Pham,

Yonghyun Choi,

Jonghoon Choi

et al.

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(7), P. 630 - 630

Published: July 4, 2020

The new era of nanotechnology has produced advanced nanomaterials applicable to various fields medicine, including diagnostic bio-imaging, chemotherapy, targeted drug delivery, and biosensors. Various materials are formed into nanoparticles, such as gold nanomaterials, carbon quantum dots, liposomes. have been functionalized widely used because they biocompatible easy design prepare. This review mainly focuses on responsive the external stimuli in drug-delivery systems. To overcome drawbacks conventional therapeutics a tumor, dual- multi-responsive behaviors nanoparticles harnessed improve efficiency from delivery point view. Issues future research related these nanomaterial-based sensitivities scope stimuli-responsive systems for nanomedicine applications discussed.

Language: Английский

Citations

168

Cell Membrane-Coated Mimics: A Methodological Approach for Fabrication, Characterization for Therapeutic Applications, and Challenges for Clinical Translation DOI Creative Commons

Vaishali Chugh,

K. Vijaya Krishna,

Abhay Pandit

et al.

ACS Nano, Journal Year: 2021, Volume and Issue: 15(11), P. 17080 - 17123

Published: Oct. 26, 2021

Cell membrane-coated (CMC) mimics are micro/nanosystems that combine an isolated cell membrane and a template of choice to mimic the functions cell. The design exploits its physicochemical biological properties for therapeutic applications. demonstrate excellent compatibility, enhanced biointerfacing capabilities, physical, chemical, tunability, ability retain cellular properties, immune escape, prolonged circulation time, protect encapsulated drug from degradation active targeting. These ease adapting them personalized clinical medicine have generated significant research interest over past decade. This review presents detailed overview recent advances in development mimics. primary focus is collate discuss components, fabrication methodologies, significance physiochemical characterization techniques validating CMC mimic. We present critical analysis two main components mimics: mapped their use scenarios. In addition, we emphasized on challenges associated with translation. Overall, this up date toolbox researchers can benefit while designing characterizing

Language: Английский

Citations

118

Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery DOI Creative Commons

Saquib Waheed,

Zhibin Li,

Fangyingnan Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Aug. 31, 2022

Abstract The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable revolutionizing health care by improving efficacy, bioavailability, drug targeting, safety. NPs are intriguing when considering medical applications because their essential unique qualities, including a significantly higher surface to mass ratio, quantum properties, the potential adsorb transport drugs other compounds. However, must overcome or navigate several biological barriers human body successfully deliver at precise locations. Engineering carrier biointerface can help main optimize delivery in more personalized manner. This review discusses significant heterogeneous how engineering promote carriers prevail over hurdles manner, thus ushering era Precision Medicine. We also summarize nanomedicines' current advantages disadvantages administration, from natural/synthetic sources clinical applications. Additionally, we explore innovative NP designs used both non-personalized customized as well they attain therapeutic strategy.

Language: Английский

Citations

113