Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(2), P. 168 - 168
Published: Feb. 8, 2024
Most
of
the
existing
methods
developed
for
predicting
antibacterial
peptides
(ABPs)
are
mostly
designed
to
target
either
gram-positive
or
gram-negative
bacteria.
In
this
study,
we
describe
a
method
that
allows
us
predict
ABPs
against
gram-positive,
gram-negative,
and
gram-variable
Firstly,
an
alignment-based
approach
using
BLAST
identify
achieved
poor
sensitivity.
Secondly,
employed
motif-based
obtained
high
precision
with
low
To
address
issue
sensitivity,
alignment-free
machine/deep
learning
techniques.
case
methods,
utilized
wide
range
peptide
features
include
different
types
composition,
binary
profiles
terminal
residues,
fastText
word
embedding.
five-fold
cross-validation
technique
has
been
used
build
models
on
training
datasets.
These
were
evaluated
independent
dataset
no
common
between
Our
machine
learning-based
model
amino
acid
profile
residues
maximum
AUC
0.93,
0.98,
0.94
bacteria,
respectively,
dataset.
performs
better
than
when
compared
approaches
A
user-friendly
web
server,
standalone
package
pip
have
facilitate
peptide-based
therapeutics.
Biomaterials Science,
Journal Year:
2022,
Volume and Issue:
10(15), P. 4058 - 4076
Published: Jan. 1, 2022
Multifunctional
wound
dressings
or
smart
with
pro-angiogenic
function,
antibacterial
properties,
anti-inflammatory/antioxidant
activity
and
tissue
adhesion
for
chronic
repair.
Infection and Drug Resistance,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 7515 - 7545
Published: Dec. 1, 2023
Abstract:
Antimicrobial
resistance,
referring
to
microorganisms'
capability
subsist
and
proliferate
even
when
there
are
antimicrobials
is
a
foremost
threat
public
health
globally.
The
appearance
of
antimicrobial
resistance
can
be
ascribed
anthropological,
animal,
environmental
factors.
Human-related
causes
include
overuse
misuse
in
medicine,
antibiotic-containing
cosmetics
biocides
utilization,
inadequate
sanitation
hygiene
settings.
Prophylactic
therapeutic
overuse,
using
as
feed
additives,
microbes
resistant
antibiotics
genes
animal
excreta,
residue
found
animal-origin
food
excreta
animals
related
contributive
factors
for
the
antibiotic
emergence
spread.
Environmental
including
naturally
existing
genes,
improper
disposal
unused
antimicrobials,
contamination
from
waste
settings,
farms,
pharmaceutical
industries,
use
agricultural
chemicals
facilitatet
its
Wildlife
has
plausible
role
Adopting
one-health
approach
involving
properly
humans,
improving
spaces
implementing
coordinated
governmental
regulations
crucial
combating
resistance.
Collaborative
cooperative
involvement
stakeholders
public,
veterinary
ecological
sectors
circumvent
problem
effectively.
Keywords:
one
health,
gene,
environment,
wildlife
Journal of Pharmaceutical Analysis,
Journal Year:
2024,
Volume and Issue:
15(1), P. 101046 - 101046
Published: July 18, 2024
Natural
antimicrobial
peptides
(AMPs)
are
promising
candidates
for
the
development
of
a
new
generation
antimicrobials
to
combat
antibiotic-resistant
pathogens.
They
have
found
extensive
applications
in
fields
medicine,
food,
and
agriculture.
However,
efficiently
screening
AMPs
from
natural
sources
poses
several
challenges,
including
low
efficiency
high
antibiotic
resistance.
This
review
focuses
on
action
mechanisms
AMPs,
both
through
membrane
non-membrane
routes.
We
thoroughly
examine
various
highly
efficient
AMP
methods,
whole-bacterial
adsorption
binding,
cell
chromatography
(CMC),
phospholipid
membrane-mediated
capillary
electrophoresis
(CE),
colorimetric
assays,
thin
layer
(TLC),
fluorescence-based
screening,
genetic
sequencing-based
analysis,
computational
mining
databases,
virtual
methods.
Additionally,
we
discuss
potential
developmental
enhancing
discovery.
provides
comprehensive
framework
identifying
within
complex
product
systems.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
10(10), P. 4033 - 4058
Published: Jan. 1, 2023
In
this
paper,
the
structure
types,
optimization
mechanism
of
mechanical
properties
and
common
application
scenarios
bionic
ordered
hydrogels
are
reviewed.
