Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(2), P. 168 - 168
Published: Feb. 8, 2024
Most
of
the
existing
methods
developed
for
predicting
antibacterial
peptides
(ABPs)
are
mostly
designed
to
target
either
gram-positive
or
gram-negative
bacteria.
In
this
study,
we
describe
a
method
that
allows
us
predict
ABPs
against
gram-positive,
gram-negative,
and
gram-variable
Firstly,
an
alignment-based
approach
using
BLAST
identify
achieved
poor
sensitivity.
Secondly,
employed
motif-based
obtained
high
precision
with
low
To
address
issue
sensitivity,
alignment-free
machine/deep
learning
techniques.
case
methods,
utilized
wide
range
peptide
features
include
different
types
composition,
binary
profiles
terminal
residues,
fastText
word
embedding.
five-fold
cross-validation
technique
has
been
used
build
models
on
training
datasets.
These
were
evaluated
independent
dataset
no
common
between
Our
machine
learning-based
model
amino
acid
profile
residues
maximum
AUC
0.93,
0.98,
0.94
bacteria,
respectively,
dataset.
performs
better
than
when
compared
approaches
A
user-friendly
web
server,
standalone
package
pip
have
facilitate
peptide-based
therapeutics.
Microbial Biotechnology,
Journal Year:
2023,
Volume and Issue:
16(4), P. 757 - 777
Published: Jan. 27, 2023
Abstract
Antimicrobial
peptides
play
a
crucial
role
in
innate
immunity,
whose
components
are
mainly
peptide‐based
molecules
with
antibacterial
properties.
Indeed,
the
exploration
of
immune
system
over
past
40
years
has
revealed
number
natural
playing
pivotal
defence
mechanisms
vertebrates
and
invertebrates,
including
amphibians,
insects,
mammalians.
This
review
provides
discussion
regarding
agents
their
structure–activity
relationships
(SARs)
aim
describing
topic
that
is
not
yet
fully
explored.
Some
growing
evidence
suggests
immunity
should
be
strongly
considered
for
development
novel
antibiotic
libraries.
Also,
due
to
constantly
rising
concern
resistance,
new
drugs
becoming
priority
global
importance.
Hence,
study
understanding
phenomena
occurring
may
inspire
compound
libraries
set
stage
overcome
drug‐resistant
pathogens.
Here,
we
provide
an
overview
importance
sources,
focusing
on
accurately
selected
molecular
structures,
SARs
recently
introduced
modifications,
latest
biotechnology
applications,
potential
against
multi‐drug
resistant
Last,
cues
describe
how
show
better
scope
action
selectivity
than
several
anti‐infective
agents,
which
characterized
by
non‐selective
activities
non‐targeted
actions
toward
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(33)
Published: June 14, 2024
Abstract
Uncontrolled
bleeding
and
wound
infections
following
severe
trauma
pose
significant
challenges
for
existing
tissue
adhesives,
primarily
due
to
their
weak
wet
adhesion,
slow
adhesion
formation,
cytotoxicity
concerns,
lack
of
antibacterial
properties.
Herein,
an
injectable
hydrogel
(denoted
as
ES
gel)
with
rapid,
robust
adhesive
sealing
inherent
activity
based
on
ε‐polylysine
a
poly(ethylene
glycol)
derivative
is
developed.
The
engineered
exhibits
rapid
gelation
behavior,
high
mechanical
strength,
strong
various
tissues,
can
sustain
ultrahigh
burst
pressure
450
mmHg.
It
also
presents
excellent
biocompatibility,
biodegradability,
properties,
on‐demand
removability.
Significantly
improved
hemostatic
efficacy
gel
compared
fibrin
glue
demonstrated
using
injury
models
in
rats
rabbits.
Remarkably,
the
effectively
halt
lethal
non‐compressible
hemorrhages
visceral
organs
(liver,
spleen,
heart)
femoral
artery
fully
anticoagulated
pigs.
Furthermore,
outperforms
commercial
products
sutureless
closure
repair
rat
liver
defect,
skin
incision,
infected
full‐thickness
models.
Overall,
this
study
highlights
promising
clinical
applications
managing
uncontrolled
hemorrhage,
closure,
repair.
Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
10(7), P. 1005 - 1018
Published: Jan. 1, 2022
Human
health
damage
and
economic
losses
due
to
bacterial
infections
are
very
serious
issues
worldwide.
Excessive
use
of
antibiotics
has
caused
an
increase
in
resistance.
Fortunately,
various
non-antibiotic
antibacterial
materials
have
been
developed
treat
without
This
review
mainly
introduces
functional
polymers
with
intrinsic
ability
their
applications
drug
delivery
systems.
The
strategies
polymer-based
coatings
include
resisting
adhesion
releasing
debris.
Their
direct
assisted
effects
also
discussed.
development
antimicrobial
drugs
is
prospected
this
review.
Pathogens,
Journal Year:
2023,
Volume and Issue:
12(2), P. 320 - 320
Published: Feb. 15, 2023
Currently,
the
cosmetic
industry
is
a
very
intensively
growing
part
of
economy.
Consumer
demands
are
adapted
to
current
lifestyle,
which
based
on
technological
innovations
and
awareness
impact
various
factors
human
health
fitness.
There
interest
in
cosmetics
environmentally
friendly
natural
compounds
exerting
health-promoting
effects.
Chemicals
with
antimicrobial
properties
used
as
ingredients
ensure
their
durability
safety.
Polyphenolic
compounds,
peptides,
essential
oils,
plant
extracts
characterized
by
these
that
can
replace
synthetic
components
cosmetics.
The
advantage
they
exhibit
antioxidant,
anti-inflammatory,
soothing
properties,
enhancing
product
value
addition
properties.
This
review
article
describes
protect
previously
preservative
agents.
Various
studies
indicate
use
increases
consumer
products
has
positive
environment.
