Bioinspired Hybrid Nanostructured PEEK Implant with Enhanced Antibacterial and Anti-inflammatory Synergy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 38989 - 39004

Published: July 22, 2024

Implant-associated infections and excessive immune responses are two major postsurgical issues for successful implantation. However, conventional strategies including antibiotic treatment inflammatory regulation always compromised due to the comodification of various biochemical agents instances functional interference. It is imperative provide implant surfaces with satisfactory antibacterial anti-inflammatory properties. Here, a dual-effect nanostructured polyetheretherketone (PEEK) surface (NP@PDA/Zn) bionic mechano-bactericidal nanopillars immobilized immunomodulatory Zn2+ designed. The constructed hybrid display remarkable performance against Gram-negative Gram-positive strains through synergy physical chemical bactericidal effects imposed by Zn2+. Meanwhile, immunoregulatory property evaluated investigation macrophage polarization both in vitro vivo, results reveal that NP@PDA/Zn could downregulate expression M1-related cytokines decrease M1 recruitment lower response. Notably, exhibited exceptional biocompatibility discerning biocidal activity between bacterial mammalian cells antioxidant effectively scavenges ROS, minimizing potential cytotoxicity. Taken together, presents convenient promising strategy combining synergistic without any mutual interference, which can support development multifunctional implant-associated materials.

Language: Английский

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Laser-based fabrication of superhydrophobic glass with high transparency and robustness

Journal of Central South University, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

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Robust superhydrophobic PEEK surface with stable antifouling and self-cleaning performances

Applied Surface Science, Journal Year: 2025, Volume and Issue: 688, P. 162326 - 162326

Published: Jan. 10, 2025

Language: Английский

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A photothermal therapy enhanced mechano-bactericidal hybrid nanostructured surface

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 645, P. 380 - 390

Published: May 3, 2023

Language: Английский

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Fabrication of antibacterial and anti-corrosive zirconia ceramics with extreme wettability by facile laser-based surface modification

Ceramics International, Journal Year: 2024, Volume and Issue: 50(13), P. 22733 - 22747

Published: April 4, 2024

Language: Английский

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Black silicon spacing effect on bactericidal efficacy against gram-positive bacteria

Nanotechnology, Journal Year: 2023, Volume and Issue: 35(2), P. 025102 - 025102

Published: Sept. 28, 2023

Abstract The morphology of regular and uniform arrays black silicon structures was evaluated for bactericidal efficacy against gram-positive, non-motile Staphylococcus epidermidis ( S. ). In this study, were fabricated using nanosphere lithography deep reactive ion etching. effects nanomorphology on bacterial killing systematically nanostructures with pitches ranging from 300 to 1400 nm pitch spherical cocci approximately 500 1000 in diameter. Our results show that nanostructure factors such as height roughness do not directly determine efficacy. Instead, the spacing between plays a crucial role determining how bacteria are stretched lysed. Nanostructures smaller more effective at bacteria, an 82 ± 3% enhancement observed nanoneedles surface compared flat control substrates.

Language: Английский

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Bioinspired Nanomaterials to Combat Microbial Biofilm and Pathogen Challenges: A Review

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 25287 - 25313

Published: Nov. 12, 2024

The emergence of antibiotic-resistant biofilms poses a significant challenge in healthcare, as these complex microbial communities demonstrate an increased resistance to conventional treatment methods. Traditional antibiotics often fail against biofilms, resulting persistent infections and failures. To address this urgent issue, innovative strategies such bioinspired nanomaterials, antimicrobial peptides, quorum sensing inhibitors, combination therapies show promise disrupting biofilm structures, enhancing activity, overcoming mechanisms. Bioinspired nanomaterials have emerged pivotal approach for tackling the challenges presented by pathogens across various sectors, including industry, environmental protection. Their advantages include enhanced biocompatibility, targeted delivery, improved efficacy formation threats. Recent advancements highlight potential solutions, nanoparticles, smart nanocarriers, surface modifications, nanozymes, combating biofilm-related issues. Despite progress nanomaterial research, remain. intricate interactions within evolving nature necessitate multidisciplinary approaches. Furthermore, translating laboratory findings into practical applications faces obstacles related scalability, stability, regulatory compliance. Future are expected focus on multifunctional nanoparticles that disrupt advanced modifications better interaction, nanocarriers nanozymes dismantle structures. This review focuses development application pathogen challenges. It emphasizes roles targeting capabilities. Additionally, explores formulating management practices, providing insights advantages, limitations, future perspectives

Language: Английский

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Engineering commonality of bionic micro/nanostructures to achieve anti-contaminant surfaces: From natural inspiration to artificial optimization

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102723 - 102723

Published: March 22, 2025

Language: Английский

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A self-activating electron transfer antibacterial strategy: Co₃O₄/TiO₂ P–N heterojunctions combined with photothermal therapy

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(6), P. 1573 - 1589

Published: Jan. 1, 2024

Implant-associated infections are significant impediments to successful surgical outcomes, often resulting from persistent bacterial contamination. It has been hypothesized that bacteria can transfer electrons semiconductors with comparable potential the biological redox (BRP). Building on this concept, we developed an antibiotic-free bactericidal system, Co3O4/TiO2-Ti, capable of achieving real-time and sustainable effects. Our study demonstrated possessing appropriately set valence band, initiated charge transfer, reactive oxygen species (ROS) production, membrane damage in adherent Staphylococcus aureus (S. aureus). Notably, vivo experiments illustrated remarkable antibacterial activity while promoting soft-tissue reconstruction demonstrating excellent cytocompatibility. Transcriptomic analysis further revealed a down-regulation aerobic respiration-associated genes up-regulation ROS-associated S. presence Co3O4/TiO2-Ti compared Ti. Kyoto Encyclopedia Genes Genomes (KEGG) gene enrichment (GSEA) identified alterations respiratory metabolism, oxidative phosphorylation, synthesis amino acid cultured Co3O4/TiO2-Ti. Furthermore, when combined near-infrared (NIR) irradiation photothermal therapy (PTT), eliminated 95.71% floating vitro. The findings suggest strategy holds substantial promise enhancing implant sterilization capabilities, thereby contributing prevention treatment through bandgap engineering implants NIR irradiation.

Language: Английский

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Evaluation of antibacterial activity on nanoline-array surfaces with different spacing

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: unknown, P. 114242 - 114242

Published: Sept. 1, 2024

Language: Английский

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