Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16
Published: Nov. 8, 2024
Language: Английский
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1401 - 1423
Published: Feb. 1, 2025
Abstract: Kidney stones constitute a common condition impacting the urinary system. In clinical diagnosis and management, traditional surgical interventions pharmacological treatments are primarily utilized; however, these methods possess inherent limitations. Presently, field of nanomedicine is undergoing significant advancements. The application nanomaterials in biosensors enables accurate assessment ion composition. Furthermore, contrast agents developed from materials can improve signal-to-noise ratio enhance image clarity. By mitigating oxidative stress-induced cellular damage, inhibit formation kidney efficacy drug delivery as effective carriers. Additionally, by modifying physical chemical properties bacteria, effectively eliminate bacterial presence, thereby preventing severe complications. This review explores advancements technology related to early detection risk factors, diagnosis, treatment their associated Keywords: nanomaterials, stones, stress, biomaterial
Language: Английский
Citations
1
Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 22, 2024
Language: Английский
Citations
5
Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122432 - 122432
Published: Dec. 21, 2023
Language: Английский
Citations
11
Current Cancer Drug Targets, Journal Year: 2024, Volume and Issue: 24(11), P. 1089 - 1103
Published: Jan. 29, 2024
Chronic inflammation is associated with a prolonged increase in various inflammatory factors. According to clinical data, it can be linked both cancer and autoimmune diseases the same patients. This raises critical question of how chronic relates seemingly opposing - tumors, which there immunosuppression, diseases, over-activation immune system. In this review, we consider as prerequisite for suppression an increased likelihood damage. We also discuss potential disease-modifying therapies targeting inflammation, helpful autoimmunity. On one hand, pro-inflammatory factors persisting areas stimulate production anti-inflammatory due negative feedback loop, eliciting suppression. other bring baseline immunity closer threshold level required triggering response using bystander activation cells. Focusing on role may open prospects more intensive drug discovery inflammation.
Language: Английский
Citations
4
Biomaterials Advances, Journal Year: 2025, Volume and Issue: 171, P. 214235 - 214235
Published: Feb. 15, 2025
Language: Английский
Citations
0
Translational Oncology, Journal Year: 2024, Volume and Issue: 46, P. 102002 - 102002
Published: May 25, 2024
Lung cancer is a highly prevalent malignancy with poor prognosis and rapid progression. It most frequently metastasizes to the bone, where it can pose severe threat patient's survival. Once metastasized, disease often incurable result in complications such as hypercalcemia, bone pain, fractures, spinal cord compression, subsequent paralysis. Exosomes are bilayer vesicle nanoparticles secreted by of extracellular vesicles, which be found almost all organisms play an essential role intercellular communication. Through their ability regulate related cells, exosomes carry bioactive molecules, including proteins, lipids, non-coding RNAs (ncRNAs), that extremely important remodeling. Studies have been conducted on lncRNA, microRNA-all ncRNAs-carried metastases lung cancer. In this review, latest progress regulatory mechanism ncRNAs carried metastasis has reviewed. The clinical use promising biomarker, drug transporter, therapeutic target was highlighted offer novel diagnostic treatment approach for patients metastases.
Language: Английский
Citations
3
Small Methods, Journal Year: 2024, Volume and Issue: unknown
Published: May 28, 2024
Abstract Ribonucleic acid (RNA) therapeutics offer a broad prospect in cancer treatment. However, their successful application requires overcoming various physiological barriers to effectively deliver RNAs the target sites. Currently, number of RNA delivery systems based on polymeric nanoparticles are developed overcome these delivery. This work provides an overview existing for gene therapy, and particularly summarizes those that entering clinical phase. then discusses core features latest research developments tumor microenvironment‐responsive polymer‐based carriers which designed pathological characteristics microenvironment. Finally, this also proposes opportunities transformation therapies into immunotherapy methods applications.
Language: Английский
Citations
3
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1366 - 1366
Published: Oct. 25, 2024
The COVID-19 pandemic has significantly accelerated progress in RNA-based therapeutics, particularly through the successful development and global rollout of mRNA vaccines. This review delves into transformative impact on RNA with a strong focus lipid nanoparticles (LNPs) as pivotal delivery platform. LNPs have proven to be critical enhancing stability, bioavailability, targeted mRNA, facilitating unprecedented success vaccines like those developed by Pfizer-BioNTech Moderna. Beyond vaccines, LNP technology is being explored for broader therapeutic applications, including treatments cancer, rare genetic disorders, infectious diseases. also discusses emerging systems, such polymeric viral vectors, which offer alternative strategies overcome existing challenges related immune responses, tissue-specific targeting. Additionally, we examine pandemic's influence regulatory processes, fast-tracked approvals therapies, surge research funding that spurred further innovation field. Public acceptance grown, laying groundwork future developments personalized medicine. By providing an in-depth analysis these advancements, this highlights long-term evolution therapeutics precision drug technologies.
Language: Английский
Citations
1
Biologics, Journal Year: 2023, Volume and Issue: 4(1), P. 1 - 16
Published: Dec. 22, 2023
Arboviruses are a group of viruses that transmitted by arthropods, such as mosquitoes, and cause significant morbidity mortality worldwide. Currently, there only few options, with restricted use, for effective vaccines against these viruses. However, recent advances in arboviral vaccine development have shown promising innovations potential preclinical clinical studies. Insect-specific been explored novel platform can induce cross-protective immunity related arboviruses. Nanoparticle-based also developed to enhance the immunogenicity stability viral antigens. Additionally, mosquito salivary proteins modulate host immune response interfere transmission being explored. Synonymous recoding, random codon shuffling, deoptimization, codon-pair is investigated strategy attenuate replication arboviruses vertebrate cells, reducing risk reverting wild-type virulence. Finally, mRNA rapidly generate express antigens eliciting robust durable responses. The challenges opportunities outlined, future directions research innovation discussed.
Language: Английский
Citations
3
Published: Oct. 4, 2024
This comprehensive chapter explores the diverse applications of coatings across various domains, ranging from biomedical engineering to energy, environmental applications, and beyond. The begins with an introduction fundamental role in engineering, providing insights into their tissue surgical procedures, emerging field smart coatings. subsequent sections delve multifaceted landscape coatings-related contexts. Section Coatings Energy elucidates impact on solar energy green buildings, storage, hydrogen technology. Through a detailed exploration advancements, this section showcases pivotal play advancing sustainable solutions. Moving further, Environment: Agriculture, Food, Separations presents thorough investigation applied agriculture, food industry, separations. Notable subsections include evolution polymer advancements paper for packaging, innovations edible utilization by-products Additionally, intersection nanotechnology In realm highlights significance water purification, wastewater treatment, gas separations, membranes these processes. final section, Other Applications Coatings, expands scope by exploring cosmetics personal hygiene, application transportation industries. provides overview versatile nature enhancing functionality, aesthetics, sustainability different sectors. offers panoramic view coatings' demonstrating versatility addressing challenges solutions, Researchers, practitioners, professionals domains will find valuable resource understanding applications.
Language: Английский
Citations
0