Astragalus membranaceus (Fisch.) Bge. administered by dissolving microneedles achieves systemic therapeutic effects at low doses DOI Creative Commons
Yiwen Chen, Zihan Zhou,

Luzheng Zhang

et al.

Journal of Traditional Chinese Medical Sciences, Journal Year: 2024, Volume and Issue: 11(3), P. 340 - 350

Published: June 5, 2024

To determine the main components of Astragalus membranaceus (Fisch.) Bge. (A. membranaceus, Huang Qi), Astragaloside IV (AIV) and polysaccharides (AP), to characterize their properties, evaluate in vivo efficacy, analyze drug diffusion using dissolving microneedle (DMN) technology vivo. Respectively, AIV- AP-loaded DMNs comprising chitosan (CTS) polyvinyl alcohol (PVA) were prepared via dual-mold forming. Their morphology, mechanical solubility, skin irritation characteristics tested. In efficacy was assessed cyclophosphamide-induced immunosuppressed mice, AIV AP by conventional methods compared, rheological properties AIV-CTS-PVA AP-CTS-PVA mixtures measured. Subcutaneous dissolution absorption microneedles (MNs) at low doses (50% – 17% intraperitoneal injection 12% 4% intravenous injection) reduced spleen index acid phosphatase activity mouse models, increased thymus index, achieved equivalent or better systemic therapeutic effects. Compared with injections, controllable solid-liquid conversion through delivery CTS-PVA MNs, resulting highly localized aggregation within 48 h, reducing initial explosive effect drug, achieving stable slow release. The present study enhances our understanding remote effects drug-loaded from a traditional Chinese medicine (TCM) perspective, thereby promoting development precise efficient TCM further expanding drug-loading range application scenarios for DMNs.

Language: Английский

Hyaluronic acid-functionalized nanoparticles enable enhanced chemo/chemodynamic therapy for the targeted treatment of colon cancer DOI
Shan Liu, Siyu Tong, Guodong Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140553 - 140553

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review DOI Creative Commons

Isaac Wong Kai Jie,

Kar Wai Alvin Lee, So Jeong Yoon

et al.

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 582 - 582

Published: April 1, 2025

Introduction: Recombinant human collagen, developed through advanced recombinant DNA technology, has emerged as a cutting-edge biomaterial with diverse applications in medicine. It addresses significant limitations of animal-derived collagens, such immunogenicity and the risk zoonotic diseases. Objective: This review evaluates clinical applications, benefits, challenges associated focusing on its potential to transform medical surgical practices. Methods: A comprehensive search was conducted MEDLINE, PubMed, Ovid databases using keywords “Recombinant Human Collagen”, “Collagen-Based Biomaterials”, “Clinical Applications”, “Tissue Repair”, “Wound Healing”. Relevant studies, including trials diagnostic were analyzed classified according Oxford Centre for Evidence-Based Medicine evidence hierarchy. Findings: collagen demonstrates superior mechanical properties controlled degradation rates compared traditional sources. Clinical studies highlight effectiveness accelerating wound closure, promoting dermal regeneration, minimizing scarring, making it particularly valuable chronic management interventions. In tissue engineering, scaffolds have shown regenerating cartilage, bone, cardiovascular tissues by supporting cell proliferation, differentiation, matrix deposition. Additionally, adaptability forming hydrogels matrices enhances suitability drug delivery systems, enabling sustained release therapeutic agents. Conclusion: represents transformative advancement practice, providing safer more effective alternative Its demonstrated success healing, highlights significantly improve patient outcomes. However, high production costs, regulatory complexities, long-term biocompatibility remain barriers widespread adoption. Further research collaboration between biotechnology developers authorities are essential fully realize potential.

Language: Английский

Citations

0
Molded All-in-One Microneedles to administer Diverse drugs in Clinical biomedical field DOI
W.J. Wang, Zhou Wang, Gaofei Zeng

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 107029 - 107029

Published: May 1, 2025

Language: Английский

Citations

0
Flurbiprofen microneedle patches for the management of acute postoperative pain DOI

Huaqing Chu,

Yanyan Zhang,

Yuan Yang

et al.

Nano Research, Journal Year: 2024, Volume and Issue: 17(8), P. 7493 - 7503

Published: June 27, 2024

Language: Английский

Citations

3
Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery DOI Creative Commons
Satish Rojekar,

Swapnali Parit,

Amol D. Gholap

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1398 - 1398

Published: Oct. 30, 2024

Microneedle technology revolutionizes ocular drug delivery by addressing challenges in treating diseases. This review explores its potential impact, recent advancements, and clinical uses. minimally invasive technique offers precise control of to the eye, with various microneedle types showing penetrate barriers cornea sclera, ensuring effective delivery. Recent advancements have improved safety efficacy, offering sustained controlled for conditions like age-related macular degeneration glaucoma. While promising, such as regulatory long-term biocompatibility persist. Overcoming these through interdisciplinary research is crucial. Ultimately, presents a revolutionary method significantly enhance disease treatment, marking new era eye care.

Language: Английский

Citations

3
Albumin-Based Microneedles for Spatiotemporal Delivery of Temozolomide and Niclosamide to Resistant Glioblastoma DOI
Zhipeng Yang, Haoyuan Li, Biao Yang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(34), P. 44518 - 44527

Published: Aug. 15, 2024

Glioblastoma (GBM) is the most common and aggressive malignant brain tumor. Standard therapy includes maximal surgical resection, radiotherapy, adjuvant temozolomide (TMZ) administration. However, rapid development of TMZ resistance impermeability blood-brain barrier (BBB) significantly hinder therapeutic efficacy. Herein, we developed spatiotemporally controlled microneedle patches (BMNs) loaded with niclosamide (NIC) to overcome GBM resistance. We found that hyaluronic acid (HA) increased viscosity bovine serum albumin (BSA) evidenced concentrations BSA/HA exert an impact degradation rates exposure high-temperature treatment, showing higher result in slower drug release. To optimize release ensure synergistic antitumor effects, a 15% solution constituting bottoms BMNs was chosen load TMZ, sustained for over 28 days, guaranteeing long-term DNA damage TMZ-resistant cells (U251-TR). Needle tips made from 10% NIC released within 14 enhancing TMZ's efficacy by inhibiting activity O6-methylguanine-DNA methyltransferase (MGMT). exhibit superior mechanical properties, bypass BBB, gradually into tumor periphery, thus proliferation expanding median survival mice. The on-demand delivery shows strong translational potential clinical applications, particularly treatment.

Language: Английский

Citations

2
Wireless power supply near-infrared light drug-loaded microneedle system for the treatment of linear skin wounds DOI
Xiaoning Zhang, Jingxian Zhu,

Xiaoya Kang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157110 - 157110

Published: Nov. 1, 2024

Language: Английский

Citations

2
Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery DOI Open Access
Satish Rojekar,

Swapnali Parit,

Amol D. Gholap

et al.

Published: June 19, 2024

Microneedle technology is a novel platform that revolutionizes ocular drug delivery and addresses critical challenges in the treatment of diseases. Routine methods, such as eye drops intravitreal injections, suffer from low bioavailability poor patient compliance. So, advanced technologies are required to overcome these challenges. minimally invasive promising alternative technique helps precisely control targeted tissues organs. This review investigates potential impact microneedle for care, underscoring recent advancements, underlying mechanisms, emerging preclinical clinical uses. Different types microneedles, including solid, coated, dissolvable, hollow, have demonstrated their capability bypass several barriers cornea sclera. ensures effective penetration delivery. The current innovations material science fabrication methods enhanced safety efficacy reducing discomfort chances infections. These offer sustained controlled delivery, which could improve therapeutic outcomes various disease conditions like age-related macular degeneration, glaucoma, diabetic neuropathy, etc. In review, studies emphasize microneedle-based delivery's feasibility benefits. include improved pharmacokinetics, reduced dosing frequency, adherence, and, most importantly, microneedles versatile platforms delivering wide range small large molecules gene therapies. Despite exciting progress, obstacles regulatory barriers, scalability, long-term biocompatibility persist. It will be essential tackle through interdisciplinary research partnerships integrate into standard use effectively. Ultimately, offers revolutionary method has significantly enhance results diseases, marking dawn new era care.

Language: Английский

Citations

1
Hydroxyethyl methacrylate hydrogel microneedles with high mechanical strength and skin penetration by template method DOI
Jung-Jie Huang,

Tieh-Fei Cheng,

Jui-Yu Wang

et al.

Journal of Polymer Research, Journal Year: 2024, Volume and Issue: 31(12)

Published: Nov. 19, 2024

Language: Английский

Citations

1
Microneedle Patches: A New Vantage Point for Diabetic Wound Treatments DOI
Ashkan Bigham, Atefeh Zarepour, Arezoo Khosravi

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Microneedle patches have emerged as a promising approach for diabetic wound healing by enabling the targeted delivery of therapeutic agents such stem cells and their derived exosomes, well localized bioactive moieties. These offer non-invasive efficient method administering payloads directly to site wound, bypassing systemic circulation minimizing potential side effects. The holds immense promoting tissue regeneration accelerating in patients. Similarly, cell-derived which are known regenerative anti-inflammatory properties, can enhance process. Furthermore, microneedle enable precise controlled release moieties, growth factors cytokines, site, creating conducive microenvironment repair regeneration. challenges associated with multifaceted. Biocompatibility issues, variability skin characteristics among patients, regulatory hurdles, scalability, cost considerations, long-term stability, patient acceptance compliance all present significant barriers widespread adoption optimization technology clinical practice. Overcoming these will require collaborative efforts from various stakeholders advance field address critical gaps research development. Ongoing focuses on enhancing biocompatibility mechanical properties materials, developing customizable technologies personalized treatment approaches, integrating advanced functionalities sensors real-time monitoring, improving engagement adherence through education support mechanisms. advancements improve management providing tailored therapies that promote faster reduce complications. This review explores current landscape context management, highlighting both need be addressed future perspectives this innovative modality.

Language: Английский

Citations

1