Cell membrane-based biomimetic vehicles for effective central nervous system target delivery: Insights and challenges

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 169 - 184

Published: June 24, 2023

Language: Английский

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Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy

Small, Journal Year: 2023, Volume and Issue: 19(23)

Published: March 11, 2023

Abstract Osteoarthritis (OA) is one of the most prevalent age‐related degenerative diseases. With an increasingly aging global population, greater numbers OA patients are providing clear economic and societal burdens. Surgical pharmacological treatments common conventional therapeutic strategies for OA, but often fall considerably short desired or optimal outcomes. development stimulus‐responsive nanoplatforms has come potential improved OA. Enhanced control, longer retention time, higher loading rates, increased sensitivity among benefits. This review summarizes advanced application drug delivery categorized by either those that depend on endogenous stimulus (reactive oxygen species, pH, enzyme, temperature), exogenous (near‐infrared ray, ultrasound, magnetic fields). The opportunities, restrictions, limitations related to these various systems, their combinations, discussed in areas such as multi‐functionality, image guidance, multi‐stimulus response. remaining constraints solutions represented clinical finally summarized.

Language: Английский

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Advanced multilayer composite dressing with co-delivery of gelsevirine and silk fibroin for burn wound healing

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 253, P. 110549 - 110549

Published: Jan. 21, 2023

Language: Английский

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Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2071 - 2071

Published: Feb. 8, 2024

Nanoencapsulation has become a recent advancement in drug delivery, enhancing stability, bioavailability, and enabling controlled, targeted substance delivery to specific cells or tissues. However, traditional nanoparticle faces challenges such as short circulation time immune recognition. To tackle these issues, cell membrane-coated nanoparticles have been suggested practical alternative. The production process involves three main stages: lysis membrane fragmentation, isolation, coating. Cell membranes are typically fragmented using hypotonic with homogenization sonication. Subsequent fragments isolated through multiple centrifugation steps. Coating can be achieved extrusion, sonication, combination of both methods. Notably, this analysis reveals the absence universally applicable method for coating, stages differ significantly their procedures. This review explores current developments approaches nanoparticles, highlighting potential an effective alternative various therapeutic applications.

Language: Английский

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Exosomes from young plasma alleviate osteoporosis through miR-217-5p-regulated osteogenesis of bone marrow mesenchymal stem cell

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 276, P. 111358 - 111358

Published: March 4, 2024

Language: Английский

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