Macrophage membrane-camouflaged pure-drug nanomedicine for synergistic chemo- and interstitial photodynamic therapy against glioblastoma

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

Advances in biomimetic nanomaterial delivery systems: harnessing nature's inspiration for targeted drug delivery

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(29), P. 7001 - 7019

Published: Jan. 1, 2024

The properties of nanomaterials make them promising and advantageous for use in drug delivery systems, but challenges arise from the immune system's recognition exogenous nanoparticles, leading to their clearance reduced targeting efficiency.

Language: Английский

---

Engineered Cell Membrane‐Coated Nanoparticles: New Strategies in Glioma Targeted Therapy and Immune Modulation

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: April 23, 2024

Gliomas, the most prevalent primary brain tumors, pose considerable challenges due to their heterogeneity, intricate tumor microenvironment (TME), and blood-brain barrier (BBB), which restrict effectiveness of traditional treatments like surgery chemotherapy. This review provides an overview engineered cell membrane technologies in glioma therapy, with a specific emphasis on targeted drug delivery modulation immune microenvironment. study investigates progress membranes, encompassing physical, chemical, genetic alterations, improve across BBB effectively target gliomas. The examination focuses interaction membrane-coated nanoparticles (ECM-NPs) TME gliomas, emphasizing potential modulate behavior enhance therapeutic efficacy. further explores involvement ECM-NPs immunomodulation techniques, highlighting impact reactions. While facing obstacles related stability manufacturing scalability, outlines forthcoming research directions focused enhancing performance. underscores promise surpassing conventional constraints, proposing novel approaches for efficacious treatment.

Language: Английский

---

Peptide-Hitchhiking for the Development of Nanosystems in Glioblastoma

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16359 - 16394

Published: June 11, 2024

Glioblastoma (GBM) remains the epitome of aggressiveness and lethality in spectrum brain tumors, primarily due to blood–brain barrier (BBB) that hinders effective treatment delivery, tumor heterogeneity, presence treatment-resistant stem cells contribute recurrence. Nanoparticles (NPs) have been used overcome these obstacles by attaching targeting ligands enhance therapeutic efficacy. Among ligands, peptides stand out their ease synthesis high selectivity. This article aims review single multiligand strategies critically. In addition, it highlights other integrate effects external stimuli, biomimetic approaches, chemical approaches as nanocatalytic medicine, revealing significant potential treating GBM with peptide-functionalized NPs. Alternative routes parenteral administration, specifically nose-to-brain delivery local within resected cavity, are also discussed. Finally, an overview them discussed provide a perspective on this promising field therapy.

Language: Английский

---

Interactions between nanoparticles and pathological changes of vascular in Alzheimer’s disease

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115219 - 115219

Published: Feb. 23, 2024

Language: Английский

---

Utilization of nanotechnology to surmount the blood-brain barrier in disorders of the central nervous system

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101457 - 101457

Published: Jan. 5, 2025

Central nervous system (CNS) diseases are a major cause of disability and death worldwide. Due to the blood-brain barrier (BBB), drug delivery for CNS is extremely challenging. Nano-delivery systems can overcome limitations BBB deliver drugs CNS, improve ability target brain provide potential therapeutic methods diseases. At same time, choice different (bypassing or crossing BBB) further optimize effect nano-drug system. This article reviews nano-delivery way enters brain. Different kinds nanoparticles were discussed in depth.

Language: Английский

---

Challenges and Material Innovations in Drug Delivery to Central Nervous System Tumors

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123180 - 123180

Published: Feb. 13, 2025

Language: Английский

---

Immune cell targeting-mediated cytomimetic drug delivery system for BBB-penetrating and precise therapy of in situ glioma

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101694 - 101694

Published: March 1, 2025

Language: Английский

---

Genetically engineered macrophages as living cell drug carriers for targeted cancer therapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 697 - 707

Published: Feb. 9, 2024

Language: Английский

---

Cell Membrane Camouflaged Biomimetic Nanoparticles as a Versatile Platform for Brain Diseases Treatment

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 10, 2024

Abstract Although there are various advancements in biomedical the past few decades, still challenges treatment of brain diseases. The main difficulties inability to deliver a therapeutic dose drug through blood‐brain barrier (BBB) and serious side effects drug. Thus, it is essential select biocompatible carriers novel tools better enhance effect disease treatment. In recent years, biomimetic nanoparticles (BNPs) based on natural cell membranes, which have excellent biocompatibility low immunogenicity, widely used diseases enable successfully cross BBB target lesions. BNPs can prolong circulation time vivo, more conducive aggregation Cell membranes (CMs) from cancer cells (CCs), red blood (RBCs), white (WBCs), so as coatings for (NPs) achieve ability target, evade clearance, or stimulate immune system. This review summarizes application different sources discusses possibilities clinical translation.

Language: Английский

---