Journal of the International Neuropsychological Society, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12
Published: Nov. 19, 2024
This systematic review was prospectively registered with PROSPERO (CRD42023426005) and the data collected in accordance Preferred Reporting Items for Systematic reviews Meta-Analyses (PRISMA) guidelines. The quality of reporting included studies evaluated CONSORT statement.
Language: Английский
International Journal of Psychiatry in Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8
Published: Feb. 24, 2025
Efficacy and safety of transcranial direct current stimulation (tDCS) in the treatment obsessive-compulsive disorder (OCD) were explored by meta-analysis. Four electronic databases (Cochrane, PubMed, Embase, Web Science) retrieved at 25/06/23. From our inclusion criteria, seven studies (N = 201 patients) included, we performed a meta-analysis using Stata15.0. Results suggested that total Y-BOCS (Yale-Brown obsessive com-pulsive scale) scale was significantly lower patients with OCD after tDCS [SMD= -0.46, 95%CI (-0.84, -0.07), I2=39%, p 0.02, Grade: high]. Subgroup analysis showed statistically significant results when duration ≤ 20 days -0.95, (-1.80, -0.10), 0.03]. Moreover, sham tDCS-treated neither different depressive symptoms nor adverse events [RR= -0.21, (-0.58, 0.15), 0.25, moderate] [RR 3.98, (0.04, 374.99), 0.55, very low], respectively. maybe reduce scores symptoms, but for reactions. are inconclusive.
Language: Английский
Citations
1
Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 33, P. 100670 - 100670
Published: Sept. 3, 2024
Exposure to chronic stress contributes considerably the development of cognitive impairments in psychiatric disorders such as depression, generalized anxiety disorder (GAD), obsessive-compulsive (OCD), post-traumatic (PTSD), and addictive behavior. Unfortunately, unlike mood-related symptoms, are not effectively treated by available therapies, a situation part resulting from still incomplete knowledge neurobiological substrates that underly domains difficulty generating interventions both efficacious safe. In this review, we will present an overview affected with specific focus on flexibility, behavioral inhibition, working memory. We then consider effects neuronal correlates function factors which may modulate interaction cognition. Finally, discuss intervention strategies for treatment stress-related gaps emerging new treatments under development. Understanding how impairment occurs during exposure is crucial make progress towards effective therapeutic approaches.
Language: Английский
Citations
7
Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 173, P. 387 - 397
Published: March 29, 2024
Language: Английский
Citations
5
Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106171 - 106171
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 374, P. 116 - 127
Published: Jan. 11, 2025
This study investigates the effects of transcranial direct current stimulation (tDCS) on brain network connectivity in individuals with obsessive-compulsive disorder (OCD). In a randomized, double-blind, sham-controlled experimental design anodal tDCS (vs. sham) was applied total 43 right-handed patients OCD, targeting right pre-supplementary motor area (pre-SMA). Cathodal reference electrode put left pre-SMA. The set as 2 mA, duration either 30 s (sham) or 1200 s. Concurrent resting-state functional MRI data were collected following (or stimulation. We employed regression dynamic causal modelling (rDCM) to extract whole effective (EC) matrices subsequently analyzing these through graph theory approaches examine changes activity across different scales. found that compared sham caused significant local connectivity. Increased recruitment level detectable sensorimotor (SMN), indicating enhanced intra-network after active tDCS. Clustering coefficient and efficiency also be increased same area. No regard global Current findings indicate single-session can effectively alter connectivities within SMN OCD patients. Given relevance connected regions for pathophysiology we believe areas might constitute an intervention normalize altered OCD. used single session, which may not reflect long-term effects.
Language: Английский
Citations
0
International Clinical Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 4, 2025
Transcranial direct current stimulation (tDCS) holds promise as a treatment for obsessive-compulsive disorder (OCD). Patients with OCD show impairment in specific domains of cognitive flexibility and response inhibition. We previously reported that tDCS produced positive clinical effect on symptoms. Here, we report secondary analysis neurocognitive data. In this randomized, double-blind, sham-controlled, crossover, multicenter feasibility study, adults diagnosis according to the diagnostic statistical manual mental disorders, fifth edition (DSM-5) received three courses clinic-based tDCS, targeting left orbitofrontal cortex (L-OFC), bilateral supplementary motor area (SMA), sham, randomly allocated delivered counterbalanced order. Cognitive assessments were conducted before 2-h after first each arm. Nineteen recruited. both L-OFC SMA significantly improved inflexibility, while sham did not (paired-sample t test, baseline vs. stimulation). No significant was found impulsivity (stop-signal reaction time) any arms. small sample patients OCD, single administration rapid improvement inflexibility but impulsivity. A definitive controlled trial OFC SMA, including markers, is indicated.
Language: Английский
Citations
0
Clinical Oral Investigations, Journal Year: 2025, Volume and Issue: 29(4)
Published: April 5, 2025
Abstract Objective This study investigates the frequency and characteristics of obsessive-compulsive (OC) symptoms Obsessive-Compulsive Personality Disorder (OCPD) in patients with Burning Mouth Syndrome (BMS). Background (OCD) is a chronic condition involving intrusive thoughts (obsessions) repetitive behaviors (compulsions), while personality disorder characterized by specific traits such as perfectionism, rigidity need for control. Both conditions frequently overlap, but their prevalence BMS has never been explored. Materials methods A total 151 were assessed using Inventory-Revised (OCI-R), Compulsive Assessment Scale (CPAS), Visual Analog (VAS), Short-Form McGill Pain Questionnaire (SF-MPQ), Hamilton Anxiety Depression scales (HAM-A, HAM-D), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness (ESS). Patients grouped based on OCI CPAS scores. Results n = 123 (81.6%) our sample females, mean age 63.19 ± 12.2 years. Clinically significant OC (OCI- R > 21) observed 41.7% sample, 37% met OCPD criteria; both present 24.5% patients. Conclusions show high traits, which should be taken into account clinicians considered therapeutic approach, given that they could complicate symptom management. Clinical relevance : By identifying these through OCI-R CPAS, may improve treatment strategies, perspective multidisciplinary tailored personalized approach.
Language: Английский
Citations
0
Journal of Cognitive Enhancement, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Language: Английский
Citations
0
Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 177, P. 39 - 45
Published: June 29, 2024
Obsessive-Compulsive Disorder (OCD) is characterized by intrusive thoughts and repetitive behaviors, with associated brain abnormalities in various regions. This study explores the correlation between neural biomarkers response to transcranial Direct Current Stimulation (tDCS) OCD patients. Using structural MRI data from two tDCS trials involving 55 patients 28 controls, cortical thickness, gray matter morphometry was analyzed. Findings revealed thicker precentral paracentral areas patients, compared control (p < 0.001). Correlations thickness treatment indicated a significant association thinner area reduced Yale-Brown Obsessive Compulsive Scale (YBOCS) scores = 0.02). While results highlight complexity of predictors, this sheds light on potential markers for Further investigations larger datasets are warranted better understand underpinnings these their implications personalized approaches.
Language: Английский
Citations
2
Neuroscience Applied, Journal Year: 2024, Volume and Issue: 3, P. 104073 - 104073
Published: Jan. 1, 2024
The ability to flexibly adapt thoughts and behaviours represents a fundamental attribute for behavioural success. Impairments in aspects of cognitive flexibility are found as transdiagnostic latent phenotypes obsessive-compulsive symptomatology present within range mental disorders the population at large. In this narrative review, we focus on attentional set-shifting aspect inflexibility, which has been largely investigated context spectrum is thought underpin perseverative symptomatology. We appraise published literature relating putative neurobiological mechanisms, methods assessment, interventional approaches, health wellbeing impacts. discuss critical knowledge gaps, promising new research avenues, potential approaches from clinical public perspective. conclude that inflexibility relevance clinicians terms understanding outcomes tailoring personalised forms treatments, professionals rigid attitudes adjustment current post-pandemic environment.
Language: Английский
Citations
1