Detection of neuronal defensive discharge information transmission and characteristics in periaqueductal gray double-subregions using PtNP/PEDOT:PSS modified microelectrode arrays DOI Creative Commons
Botao Lu, Penghui Fan, Ming Li

et al.

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: May 31, 2023

Threatened animals respond with appropriate defensive behaviors to survive. It has been accepted that midbrain periaqueductal gray (PAG) plays an essential role in the circuitry system and organizes behavioral responses. However, correlation of different PAG subregions expression remain largely unexplored. Here, we designed manufactured a microelectrode array (MEA) simultaneously detect activities dPAG vPAG neurons freely behaving rats. To improve detection performance MEAs, PtNP/PEDOT:PSS nanocomposites were modified onto MEAs. Subsequently, predator odor was used induce rat's innate fear, changes information transmission neuronal detected vPAG. Our results showed participated but activation degree distinct defense behaviors. During flight, responses stronger earlier than vPAG, while responded more strongly during freezing. By applying high-performance MEA, it revealed neural spread from activated weakly research also exhibited discharge characteristics, regulation burst-firing patterns. The slow continuous firing cooresponded long-term freezing demonstrated important controlling aspects provided novel insights for investigating electrophysiological perspective.

Language: Английский

How Instructions, Learning, and Expectations Shape Pain and Neurobiological Responses DOI Creative Commons
Lauren Y. Atlas

Annual Review of Neuroscience, Journal Year: 2023, Volume and Issue: 46(1), P. 167 - 189

Published: March 14, 2023

Treatment outcomes are strongly influenced by expectations, as evidenced the placebo effect. Meta-analyses of clinical trials reveal that effects strongest in pain, indicating psychosocial factors directly influence pain. In this review, I focus on neural and psychological mechanisms which instructions, learning, expectations shape subjective address new experimental designs help researchers tease apart impact these distinct processes evaluate evidence regarding cognitive Studies modulate pain through parallel circuits include both pain-specific domain-general such those involved affect learning. then review how verbal instructions outcomes, including analgesia responses to pharmacological treatments, discuss implications for future work.

Language: Английский

Citations

19
Peptidergic and functional delineation of the Edinger-Westphal nucleus DOI Creative Commons
Michael F. Priest, Sara Nicole Freda, Isabelle J. Rieth

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(8), P. 112992 - 112992

Published: Aug. 1, 2023

Many neuronal populations that release fast-acting excitatory and inhibitory neurotransmitters in the brain also contain slower-acting neuropeptides. These facultative peptidergic cell types are common, but it remains uncertain whether neurons solely peptides exist. Our fluorescence situ hybridization, genetically targeted electron microscopy, electrophysiological characterization suggest most of non-cholinergic, centrally projecting Edinger-Westphal nucleus mice obligately peptidergic. We further show, using anterograde projection mapping, monosynaptic retrograde tracing, angled-tip fiber photometry, chemogenetic modulation ablation conjunction with canonical assays for anxiety, this population activates response to loss motor control promotes anxiety responses. Together, these findings elucidate an integrative, ethologically relevant role functionally align periaqueductal gray, where resides. This work advances our understanding provides a framework future investigations systems.

Language: Английский

Citations

19
Periaqueductal Gray and Rostromedial Tegmental Inhibitory Afferents to VTA Have Distinct Synaptic Plasticity and Opiate Sensitivity DOI Creative Commons
Robyn St. Laurent, Valentina Martínez Damonte, Ayumi Tsuda

et al.

Neuron, Journal Year: 2020, Volume and Issue: 106(4), P. 624 - 636.e4

Published: March 18, 2020

Language: Английский

Citations

41
Play and tickling responses map to the lateral columns of the rat periaqueductal gray DOI Creative Commons

Natalie Gloveli,

Jean Simonnet, Wei Tang

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(19), P. 3041 - 3052.e7

Published: July 28, 2023

The persistence of play after decortication points to a subcortical mechanism control. We found that global blockade the rat periaqueductal gray with either muscimol or lidocaine interfered ticklishness and play. recorded vocalizations neural activity from young, playful rats during interspecific touch, play, tickling. Rats vocalized weakly touch more strongly Periaqueductal units showed diverse but strong modulation tickling Hierarchical clustering based on neuronal responses revealed functional clusters mapping different columns. Specifically, we observed play-neutral/tickling-inhibited tickling/play-neutral in dorsolateral dorsomedial In contrast, play/tickling-excited mapped lateral columns were suppressed by anxiogenic conditions. Optogenetic inactivation disrupted conclude are decisive for laughter.

Language: Английский

Citations

15
Why reliving is not remembering and the unique neurobiological representation of traumatic memory DOI
Breanne E. Kearney,

Ruth A. Lanius

Nature Mental Health, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Language: Английский

Citations

6
Interoception in Autism: A Narrative Review of Behavioral and Neurobiological Data DOI Creative Commons
Fernanda Loureiro, Sofronia M Ringold, Lisa Aziz‐Zadeh

et al.

Psychology Research and Behavior Management, Journal Year: 2024, Volume and Issue: Volume 17, P. 1841 - 1853

Published: May 1, 2024

While exteroceptive sensory processing is a hallmark of autism spectrum disorder, how interoceptive may impact and contribute to symptomatology remains unclear. In this comprehensive narrative review on interoception in autism, we discuss: 1) difficulties with assessing interoception; 2) potential differences; 3) interactions between neural systems for interoception, attention, sensorimotor processing, cognition; 4) differences circuits involved interoception. general, there are mixed findings autism. Nevertheless, some data indicate integration information symptomatology. Neurologically, be impacted by the development, morphometry, connectivity key hubs (vagal brainstem, thalamus, insula), though much work needed topic.

Language: Английский

Citations

5
Deep brain stimulation of midbrain locomotor circuits in the freely moving pig DOI Creative Commons
Stephano J. Chang, Andrea J. Santamaría, Francisco J. Sánchez

et al.

Brain stimulation, Journal Year: 2021, Volume and Issue: 14(3), P. 467 - 476

Published: Feb. 27, 2021

Deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR) has been studied as a therapeutic target in rodent models stroke, parkinsonism, and spinal cord injury. Clinical DBS trials have targeted closely related pedunculopontine nucleus patients with Parkinson's disease therapy for gait dysfunction, mixed reported outcomes. Recent studies suggest that optimizing MLR could improve its effectiveness.We sought to determine if stereotaxic targeting midbrain pig, anatomically similar previously identified other species, initiate modulate ongoing locomotion, step towards generating large animal neuromodulation model gait.We implanted Medtronic 3389 electrodes into putative structures Yucatan micropigs characterize effects acute this region, using EMG recordings, joint kinematics, speed measurements on manual treadmill.MLR initiated augmented locomotion freely moving micropigs. Effective sites centered around cuneiform frequency controlled stepping frequency. Off-target evoked defensive aversive behaviors precluded animals.Pigs appear an can be used gait-promoting center. These results indicate pig is useful guide future clinical cases deficiencies associated such conditions disease, injury, or stroke.

Language: Английский

Citations

30
Upregulation of breathing rate during running exercise by central locomotor circuits in mice DOI Creative Commons
Coralie Hérent, Séverine Diem, Giovanni Usseglio

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 22, 2023

Abstract While respiratory adaptation to exercise is compulsory cope with the increased metabolic demand, neural signals at stake remain poorly identified. Using circuit tracing and activity interference strategies in mice, we uncover here two systems by which central locomotor network can enable augmentation relation running activity. One originates mesencephalic region (MLR), a conserved controller. Through direct projections onto neurons of preBötzinger complex that generate inspiratory rhythm, MLR trigger moderate increase frequency, prior to, or even absence of, locomotion. The other lumbar enlargement spinal cord containing hindlimb motor circuits. When activated, through retrotrapezoid nucleus (RTN), it also potently upregulates breathing rate. On top identifying critical underpinnings for hyperpnea, these data expand functional implication cell types pathways are typically regarded as “locomotor” “respiratory” related.

Language: Английский

Citations

12
Gait control by the frontal lobe DOI
Kaoru Takakusaki

Handbook of clinical neurology, Journal Year: 2023, Volume and Issue: unknown, P. 103 - 126

Published: Jan. 1, 2023

Language: Английский

Citations

12
Pathway-specific inputs to the superior colliculus support flexible responses to visual threat DOI Creative Commons
Chen Li, Norma K. Kühn, Ilayda Alkislar

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(35)

Published: Aug. 30, 2023

Behavioral flexibility requires directing feedforward sensory information to appropriate targets. In the superior colliculus, divergent outputs orchestrate different responses visual threats, but circuit organization enabling flexible routing of remains unknown. To determine this structure, we focused on inhibitory projection (Gad2) neurons. Trans-synaptic tracing and neuronal recordings revealed that Gad2 neurons projecting lateral geniculate nucleus (LGN) parabigeminal (PBG) form two separate populations, each receiving a set non-retinal inputs. Inhibiting LGN- or PBG-projecting resulted in opposing effects behavior; increasing freezing escape probability looming, respectively. Optogenetic activation selected inputs cells predictably regulated threat. These data suggest projection-specific sampling brain-wide provides design principle enables be selectively routed produce context-specific behavior.

Language: Английский

Citations

12