Journal of Oral Biosciences, Journal Year: 2024, Volume and Issue: unknown, P. 100606 - 100606
Published: Dec. 1, 2024
Language: Английский
iScience, Journal Year: 2025, Volume and Issue: 28(3), P. 112006 - 112006
Published: Feb. 12, 2025
The large-caliber primary afferents innervating the spindles of jaw-closing muscles have their cell bodies located centrally in mesencephalic trigeminal nucleus (NVmes). We shown, an acid-induced jaw muscle chronic myalgia model, that these exhibit increased excitability and ectopic discharges emerge from subthreshold membrane oscillations (SMOs) supported by a persistent sodium current (I NaP) exquisitely sensitive to extracellular Ca2+-decreases. Here, we explore if Ca2+-binding astrocytic protein, S100β, contributes this hyperexcitability emergence aim localize site where discharge arises using whole-cell patch-clamp recordings on mice brain slices. found astrocytes, lowering [Ca2+]e at focal points along axons NVmes neurons through enhance amplitude NaV1.6-dependent SMOs, leading firing. These findings suggest crucial role for astrocytes regulation raise questions about neuron-astrocyte interaction as key contributor several pathologies.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: May 8, 2024
Abstract Facial expressions and movements, from a subtle ephemeral grimace, to vigorous rapid chewing, offer direct insights into the moment-to-moment change of neural physiological processes. Mice, with discernible facial responses evolutionarily conserved mammalian movement control circuits, provide an ideal model unravel link between underlying states. However, existing frameworks lack spatial or temporal resolution sensitively track all movements mouse face, due its small conical form factor. We introduce Cheese3D, computer vision system that captures high-speed 3D motion entire face (including ears, eyes, whisker pad, jaw, while covering both sides face) using calibrated six-camera array. The interpretable framework extracts dynamics anatomically-meaningful features in absolute world units at sub-millimeter precision. precise face-wide data generated by Cheese3D provides clear insights, as shown proof-of-principle experiments predicting time under general anesthesia changing patterns, inferring tooth muscle anatomy fast ingestion motions across measuring minute differences evoked brainstem stimulation, relating activity spontaneous including expressive only measurable (e.g., angles ear motion). can serve discovery tool renders highly readout otherwise hidden internal
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 8, 2024
Abstract The mesencephalic trigeminal nucleus is unique in that it contains the cell bodies of large-caliber primary afferents are usually located periphery dorsal root ganglia or ganglia. activity these typically associated with proprioception jaw-closing muscles mechanoreception on teeth and periodontal ligament. However, like other from body which display ectopic firing neuropathic pain models, exhibit increased excitability discharges even a relatively mild muscle model. These normally emerge subthreshold membrane oscillations (SMOs) supported by persistent sodium current ( I NaP ) exquisitely sensitive to extracellular Ca 2+ -decreases. We have shown main sensory release -binding astrocytic protein, S100β, sufficient modulate this current. Here, we explore if astrocyte-dependent mechanism contributes emergence hyperexcitability aim localize cellular site where discharge may arise using whole-cell patch-clamp recordings, confocal imaging, immunohistochemistry methods mice brain slices. found astrocytes, lowering [Ca ] e at focal points along axons NVmes neurons through enhance amplitude Na V 1.6-dependent SMOs leading firing. findings suggest crucial role for astrocytes regulation raise questions about neuron-astrocyte interaction as key contributor several pathologies.
Language: Английский
Citations
1
BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 29, 2024
Language: Английский
Citations
1
Journal of Evaluation in Clinical Practice, Journal Year: 2024, Volume and Issue: 31(1)
Published: Dec. 20, 2024
ABSTRACT Background Chewing is a fundamental motor activity, but there no specific assessment tool in Italian for paediatric rehabilitation. The Karaduman Performance Scale (KCPS) performance‐based that allow to classify chewing performance childhood. Objective To translate, culturally adapt and assess reliability, criterion validity cross‐cultural of the KCPS into population. Methods Following international guidelines, was translated adapted Italian. Inter‐rater reliability measured using intraclass correlation coefficient (ICC), Pearson comparing score with Paediatric Screening‐Priority Evaluation Dysphagia (PS‐PED), examined across diagnostic groups. Results study included 165 children mean age 6.33 different health conditions, namely autism spectrum disorder, cerebral palsy genetic syndromes. analysis revealed reliable measure ICC 0.93, moderate positive linear PS‐PED (Pearson 0.48) found. In each group, disorders were found, highlighting characteristics. Conclusions Despite limited sample need exploring relationship abilities severity diseases, found valid determining level Now clinicians can use it more confidence their clinical practice research.
Language: Английский
Citations
1
Науковий вісник Ужгородського університету Серія Медицина, Journal Year: 2024, Volume and Issue: 1(69), P. 110 - 113
Published: Jan. 1, 2024
Aim. Investigation of the specific interaction elements stomatognathic apparatus and their functional-occlusal relationships in patients with occlusal disharmony determination impact these factors on development temporomandibular joint dysfunction (TMD) through conducting clinical research, utilizing instrumental diagnostic methods, as well collecting analyzing statistical data. Materials Methods. The research includes an analysis functional occlusion dental disharmony. methodology incorporates laboratory considering various aspects anatomy joints, muscle activity, movements lower jaw. use high-precision tools allows for identification changes topography activity. Results. obtained results highlight importance during prosthetic treatment indicate a connection between disturbances, jaw, Temporomandibular Disorders. Aspects such asymmetry activity trauma to nerve endings underscore necessity avoiding unimpeded displacement jaw interventions. Conclusions. Based conducted analysis, it has been determined that restoration is great preventing issues recession, hypersensitivity, periodontal trauma, dysfunction. relevance studying modern orthopedic emphasized. indicates further scientific studies improve approaches prevention anomalies.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 2, 2024
Abstract The first phase of feeding consists in acquiring solid foods from the environment by biting, and their preparation for swallowing chewing. These actions require precise coordination tens orofacial muscles jaw tongue. siege this motor patterning is known to be reticular formation, a complex poorly mapped region hindbrain, but neuron groups involved are still elusive. Here, we characterize group interneurons located supratrigeminal area that express homeodomain transcription factor Phox2b . This nucleus — Sup5 premotor both jaw-closing jaw-opener motoneurons receives direct input cranial sensory afferents, cortex satiation related nuclei. Its activity differentially tracks lapping, biting chewing movements, suggesting its involvement elaboration distinct patterns vivo. Acute global activation or inhibition optogenetics interrupt volitional sequences. Thus, an obligatory subcortical node, topologically genetically defined, neural circuits control oral feeding. Teaser A defined cluster neurons hindbrain essential relay food.
Language: Английский
Citations
0
Scientific Journal of Sport and Performance, Journal Year: 2024, Volume and Issue: 3(4), P. 485 - 492
Published: July 19, 2024
Chewing is a simple and effective method for managing psychological stress maintaining optimal physical mental health. This study aimed to systematically review the potential benefits disadvantages of chewing in sports. We conducted comprehensive literature search all relevant articles sourced from Cochrane Central Register Controlled Trials, MEDLINE, PUBMED. used “chewing OR mastication masticatory” “sport sports training exercise fitness athletic athlete performance.” adopted three-step screening process titles, abstracts, full-texts select eligible articles. After applying our inclusion exclusion criteria, we performed full-text 101 The results showed that could improve muscle activation, force production, strength, postural stability, positively affecting performance, especially rugby, judo, kendo, climbing. beneficial effects on performance may be associated with activation central nervous system circuits, an increase arousal level alertness, improvements cognitive ability. In contrast, gum poses risk laryngeal spasm during activities, such as swimming or cricket. Attention should paid while engaging
Language: Английский
Citations
0
Archives of Oral Biology, Journal Year: 2024, Volume and Issue: 171, P. 106163 - 106163
Published: Dec. 12, 2024
Language: Английский
Citations
0
Journal of Oral Biosciences, Journal Year: 2024, Volume and Issue: unknown, P. 100606 - 100606
Published: Dec. 1, 2024
Language: Английский
Citations
0