Recommendations for a better understanding of sex and gender in neuroscience of mental health DOI Open Access
Lara M. Wierenga, Amber Ruigrok,

Eira Ranheim Aksnes

et al.

Published: April 29, 2023

There are prominent sex/gender differences in the prevalence, expression and lifespan course of mental health neurodiverse conditions. Yet underlying sex gender related mechanisms their interactions still not fully understood. This lack knowledge has harmful consequences for those suffering from problems. Hence, we set up a co-creation session one-week workshop with multidisciplinary team 25 researchers, clinicians policy makers, to identify main barriers research neuroscience health. Based on this work, here provide recommendations methodologies, translational stakeholder involvement. These include guidelines recording, reporting, analysis beyond binary groups, open science. Improved understanding may benefit public as is an important step towards precision medicine function archetype studying diversity.

Language: Английский

The role of brain structure in the association between pubertal timing and depression risk in an early adolescent sample (the ABCD Study®): A registered report DOI Creative Commons
Niamh MacSweeney, Judith Allardyce, Amelia J. Edmondson-Stait

et al.

Developmental Cognitive Neuroscience, Journal Year: 2023, Volume and Issue: 60, P. 101223 - 101223

Published: Feb. 25, 2023

Earlier pubertal timing is associated with higher rates of depressive disorders in adolescence. Neuroimaging studies report brain structural associations both and depression. However, whether structure mediates the relationship between depression remains unclear. The current registered examined (indexed via perceived development), (cortical subcortical metrics, white matter microstructure) symptoms a large sample (N = ∼5000) adolescents (aged 9–13 years) from Adolescent Brain Cognitive Development (ABCD) Study. We used three waves follow-up data when youth were aged 10–11 years, 11–12 12–13 respectively. generalised linear-mixed models (H1) equation modelling (H2 & H3) to test our hypotheses. hypothesised that earlier at Year 1 would be increased 3 (H1), this mediated by global (H2a-b) regional (H3a-g) measures 2. Global included reduced cortical volume, thickness, surface area sulcal depth. Regional thickness volume temporal fronto-parietal areas, ventral diencephalon, depth pars orbitalis, fractional anisotropy cortico-striatal tract corpus callosum. These regions interest informed pilot analyses using baseline ABCD 9–10 years. was two years later. magnitude effect stronger female association remained significant controlling for parental depression, family income, BMI females but not male youth. Our did however mediate later symptoms. present results demonstrate youth, particularly females, who begin puberty ahead their peers are an risk adolescent-onset Future work should explore additional biological socio-environmental factors may affect so we can identify targets intervention help these at-risk

Language: Английский

Citations

14
Profiling intra- and inter-individual differences in brain development across early adolescence DOI Creative Commons
Katherine L. Bottenhorn,

Carlos Cardenas‐Iniguez,

Kathryn L. Mills

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 279, P. 120287 - 120287

Published: Aug. 1, 2023

As we move toward population-level developmental neuroscience, understanding intra- and inter-individual variability in brain maturation sources of neurodevelopmental heterogeneity becomes paramount. Large-scale, longitudinal neuroimaging studies have uncovered group-level trajectories, while recent work has begun to untangle differences, they remain largely unclear. Here, aim quantify both across facets neurodevelopment early adolescence (ages 8.92 13.83 years) the Adolescent Brain Cognitive Development (ABCD) Study examine as a function age, sex, puberty. Our results provide novel insight into differences annualized percent change macrostructure, microstructure, functional development from ages 9-13 years old. These findings reveal moderate age-related intra-individual change, but only few measures cortical macro- microstructure development. Greater were seen mid-pubertal individuals, except for aspects white matter that more variable between prepubertal individuals some tracts. Although sexes contributed macrostructure regions brain, found limited support hypotheses regarding greater male-than-female variability. This highlights pockets individual adolescent development, also highlighting regional facilitate future investigations quantifying probing nuances normative deviations therefrom.

Language: Английский

Citations

14
High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration DOI
Xiuting Yao, Chenxi Yang,

Xirui Jia

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 119, P. 236 - 250

Published: April 9, 2024

Language: Английский

Citations

6
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study DOI Creative Commons
Azzurra Invernizzi, Stefano Renzetti, Christoph van Thriel

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 2, 2024

Language: Английский

Citations

6
Radically reframing studies on neurobiology and socioeconomic circumstances: A call for social justice-oriented neuroscience DOI Creative Commons
E. Kate Webb,

Carlos Cardenas‐Iniguez,

Robyn D. Douglas

et al.

Frontiers in Integrative Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Sept. 2, 2022

Socioeconomic circumstances are associated with symptoms and diagnostic status of nearly all mental health conditions. Given these robust relationships, neuroscientists have attempted to elucidate how socioeconomic-based adversity “gets under the skin.” Historically, this work emphasized individual proxies socioeconomic position (e.g., income, education), ignoring effects broader contexts neighborhood disadvantage) which may uniquely contribute chronic stress. This omission represented a disconnect between neuroscience other allied fields that recognized is undeniably linked interactions systems power characteristics. More recently, has considered sociopolitical context affects brain structure function; however, products exciting line research lacked critical sociological historical perspectives. While empirical evidence on topic burgeoning, cultural, ethical, societal, legal implications been elusive. Although mechanisms by impact function be similar across people, not everyone exposed factors at rates. Individuals from ethnoracially minoritized groups disproportionally disadvantage. Thus, inequities examined in undergirding forms oppression, namely structural racism. We utilize holistic, interdisciplinary approach interpret findings interweave relevant theories public health, social sciences, Black feminist thought. In perspective piece, we discuss complex relationship continues exist academic institutions underserved surrounding communities, acknowledging areas historically harmed and/or excluded structurally disadvantaged communities. conclude envisioning can used; just inform policymakers, but also engage partner communities shape future direction human research.

Language: Английский

Citations

22
Effects of COVID-19 pandemic on structural brain development in early adolescence DOI Creative Commons
Lina van Drunen, Yara J. Toenders, Lara M. Wierenga

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: April 5, 2023

Abstract The COVID-19 pandemic caused a global health crisis with large behavioral effects and serious stress social consequences. Particularly, teenagers suffered pandemic-related restrictions including school closures. This study examined whether how structural brain development was influenced by the length associated accumulating or resilience of development. We investigated changes in regions (medial prefrontal cortex: mPFC; temporoparietal junction: TPJ) as well stress-related hippocampus amygdala, using longitudinal design 2 MRI waves. selected two age-matched subgroups (9–13 years old), one tested before (n = 114) other during (peri-pandemic group, n 204) pandemic. Results indicated that peri -pandemic group showed accelerated mPFC compared to before- group. Furthermore, TPJ growth immediate followed possibly subsequent recovery returned typical developmental pattern. No were observed for amygdala. findings this region-of-interest suggest experiencing measures had accelerating on but negative effects. Follow-up assessments are needed test acceleration over longer periods.

Language: Английский

Citations

13
A Neuroecosocial Perspective on Adolescent Development DOI Creative Commons

Suparna Choudhury,

Blanca Piera Pi‐Sunyer, Sarah‐Jayne Blakemore

et al.

Annual Review of Developmental Psychology, Journal Year: 2023, Volume and Issue: 5(1), P. 285 - 307

Published: Aug. 24, 2023

Adolescence is a period of life that encompasses biological maturation and profound change in social roles. It also associated with the onset mental health problems. The field developmental cognitive neuroscience has advanced our understanding development brain within its immediate cultural context. In time rising rates problems among adolescents across globe, it important to understand how wider societal, structural, contexts young people are impacting their social-cognitive maturation. this article, we review landscape youth during adolescence consider potential role research effects current determinants adolescent health, including socioeconomic inequality, city living, eco-anxiety about climate crisis.

Language: Английский

Citations

12
Genetic and brain similarity independently predict childhood anthropometrics and neighborhood socioeconomic conditions DOI Creative Commons
Andreas Dahl, Espen Moen Eilertsen,

Sara F. Rodriguez-Cabello

et al.

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 65, P. 101339 - 101339

Published: Jan. 4, 2024

Linking the developing brain with individual differences in clinical and demographic traits is challenging due to substantial interindividual heterogeneity of anatomy organization. Here we employ an integrative approach that parses both cortical thickness common genetic variants, assess their effects on a wide set childhood traits. The uses linear mixed model framework obtain unique each type similarity, as well covariance. We this sample 7760 unrelated children ABCD cohort baseline (mean age 9.9, 46.8% female). In general, associations between similarity were limited anthropometrics such height, weight, birth marker neighborhood socioeconomic conditions. Common variants explained significant proportions variance across nearly all included outcomes, although estimates somewhat lower than previous reports. No covariance was found. present findings highlight connection conditions brain, which appear be independent from population-based sample.

Language: Английский

Citations

4
Associations of recent stressful life events with anxiety symptoms among Chinese adolescents with a consideration of family functioning DOI Creative Commons
Yilin Hua, Weiqing Jiang,

Yitong He

et al.

European journal of psychotraumatology, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 10, 2024

The association between stressful life events (SLEs) and adolescent anxiety symptoms has been extensively studied, but the specific impacts of different SLEs domains remain inconclusive. Moreover, limited research examined role family functioning in these associations.

Language: Английский

Citations

4
Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence DOI
Qingyang Li, Miao Cao, Dan J. Stein

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0