Sleep regularity and major adverse cardiovascular events: a device-based prospective study in 72 269 UK adults

Journal of Epidemiology & Community Health, Journal Year: 2024, Volume and Issue: unknown, P. jech - 222795

Published: Nov. 27, 2024

Background This study examines the associations between device-measured sleep regularity and risk of major adverse cardiovascular events (MACE), aims to determine whether sufficient duration attenuates or eliminates effects irregular on MACE risk. Methods A prospective cohort adults aged 40–79 years from UK Biobank who wore wrist-attached accelerometers for 7 days was conducted. Sleep Regularity Index (SRI) scores were calculated each participant using a validated algorithm, categorised as (SRI <71.6), moderately 71.6 87.3), regular >87.3 (reference group)). Information its subtypes (myocardial infarction, heart failure, stroke) obtained inpatient hospitalisation death records. Results We analysed data 72 269 individuals followed 8 years, without previous history an event in first year follow-up. Irregular (HR 1.26, 95% CI 1.16 1.37) sleepers 1.08, 1.01 1.70) at higher compared with sleepers. Dose-response analyses treating SRI continuous measure showed that associated near-linear fashion, steeper reduction (better) scores. Joint meeting age-specific recommendation offsets 1.07, 0.96 1.18), but not 1.19, 1.06 1.35). Conclusions strongly Adequate offset these among supports inclusion public health guidelines clinical practice factor disease.

Language: Английский

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Cardiovascular health metrics defined by Life's Essential 8 scores and subsequent macrovascular and microvascular complications in individuals with type 2 diabetes: A prospective cohort study

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(7), P. 2673 - 2683

Published: April 1, 2024

Abstract Aim To investigate the association between cardiovascular health metrics defined by Life's Essential 8 (LE8) scores and vascular complications among individuals with type 2 diabetes (T2D). Materials Methods This prospective study included 11 033 participants T2D, all devoid of macrovascular diseases (including peripheral artery disease) microvascular (e.g. diabetic retinopathy, neuropathy nephropathy) at baseline from UK Biobank. The LE8 score comprised eight metrics: smoking, body mass index, physical activity, non‐high‐density lipoprotein cholesterol, blood pressure, glycated haemoglobin, diet sleep duration. Cox proportional hazards models were established to assess associations incident complications. Results During a median follow‐up 12.1 years, we identified 1975 cases 1797 After adjusting for potential confounders, each 10‐point increase in was associated an 18% lower risk 15% Comparing highest lowest quartiles revealed hazard ratios 0.55 (95% confidence interval 0.47‐0.62) diseases, 0.61 0.53‐0.70) remained robust across series sensitivity analyses nearly subgroups. Conclusion Higher T2D. These findings underscore significance adopting fundamental strategies maintain optimal curtail developing

Language: Английский

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Association of change in cardiovascular health based on life's essential 8 with incident cardiovascular disease

American Journal of Preventive Cardiology, Journal Year: 2024, Volume and Issue: 18, P. 100668 - 100668

Published: April 5, 2024

To evaluate whether and to what extent changes in cardiovascular health (CVH) based on life's essential 8 (LE8) are associated with incident disease (CVD).

Language: Английский

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Associations between life’s essential 8 and metabolic health among us adults: insights of NHANES from 2005 to 2018

Acta Diabetologica, Journal Year: 2024, Volume and Issue: 61(8), P. 963 - 974

Published: April 7, 2024

Language: Английский

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Dose-response associations of the American Heart Association's new “Life's essential 8” metrics with all-cause and cardiovascular mortality in a nationally representative sample from the United States

Progress in Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 85, P. 31 - 37

Published: July 1, 2024

Language: Английский

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Life's Essential 8 and the risk of cardiovascular disease: a systematic review and meta-analysis

European Journal of Preventive Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

Abstract Aims The benefits of achieving optimal cardiovascular health (CVH) through Life's Simple 7 (LS7) are well-documented across diverse populations. In this study, we assess the updated metrics, Essential 8 (LE8), and its association with long-term disease (CVD) outcomes mortality. Methods results We conducted a comprehensive systematic review, searching PubMed, Google Scholar, Cochrane Library, ScienceDirect from January 2022 until June 2024, focusing on studies that specifically assessed impact LE8 CVH. statistical analysis used RevMan 5.4 applied random effects model to synthesize hazard ratios (HRs) for primary secondary outcomes. This study is registered in PROSPERO (CRD42024558493). Our final comprised 34 observational studies, encompassing 1 786 664 participants aged 18–80 years, an average follow-up approximately 11.6 years. Pooled revealed statistically significant decrease risk CVD among individuals higher scores compared those lower scores, HR 0.47 (95% CI: 0.39–0.56, P &lt; 0.00001). Higher were also associated reductions both all-cause mortality (HR: 0.54, 95% 0.43–0.69, 0.00001) CVD-related 0.37, 0.26–0.52, 0.00001. Moreover, high have 56% coronary heart 48% stroke. Conclusion has strong inverse mortality, corresponding significantly levels.

Language: Английский

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The correlation between Life’s essential 8 and cardiovascular disease and mortality in individuals with nonalcoholic fatty liver disease: a cross-sectional study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 14, 2024

It is currently unclear whether there a connection between Life's Essential 8 (LE8) and cardiovascular disease (CVD), as well mortality in people with nonalcoholic fatty liver (NAFLD). Our goal was to explore these relationships by examining data collected the National Health Nutrition Examination Survey (NHANES) from 2005 2018. We identified eligible participants NAFLD based on NHANES 2005-2018 data. CVD status acquired through self-reported information, using Death Index, were prospectively matched. The diagnosis of relied noninvasive biomarkers. research involved 9094 individuals who having NAFLD, mean age 52.05 years. Each incremental LE8 score exhibited significant association, leading 3%, 4%, 4% reduction odds experiencing CVD, ischemic heart disease, congestive failure, coronary attack, angina, stroke NAFLD. A strong correlation found maintaining superior level Cardiovascular (CVH), shown ranging 80 100, reduced occurrence its various forms (all p for trend < 0.0001). Likewise, demonstrated protective benefits showing that following high CVH (in contrast low CVH) linked reductions 64%, 71%, 74% all-cause, cancer mortality, respectively. Restricted cubic spline analyses suggested noteworthy dose-response specifically types nonlinear mortality. Interaction highlighted race effect modifiers. CVH, evaluated LE8, an independent association decreased risk findings substantiate adhering may alleviate excessive burden context

Language: Английский

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Cardiovascular Health Score and Atherosclerotic Cardiovascular Disease in the Million Veteran Program

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(12), P. e2447902 - e2447902

Published: Dec. 6, 2024

Importance The American Heart Association proposed Life’s Essential 8 (LE8) as an enhanced measurement tool for cardiovascular health. Objective To examine the association of LE8 with risk atherosclerotic disease (ASCVD) incidence and prognosis in veterans. Design, Setting, Participants This was a prospective cohort study US veterans enrolled Department Veterans Affairs (VA) Million Veteran Program (MVP) between 2011 2022. Data were analyzed from 2023 to 2024. Exposure score ranged 0 100, higher indicating better Main Outcomes Measures primary outcome total ASCVD without baseline ASCVD, secondary major adverse event (MACE) among at baseline. Results A 413 052 (mean [SD] age, 65.8 [12.1] years; 378 162 [91.6%] male) included. Based on 1.7 million person-years follow-up 279 868 any baseline, 45 067 had during follow-up. Total each component factor associated incident inverse, linear, dose-response manner. For prior those 80 100 lower compared 49 (adjusted hazard ratio [aHR], 0.36 [95% CI, 0.35-0.38]). Similarly, MACE significantly regardless status (with ASCVD: aHR, 0.52 0.48-0.56]; 0.14 0.13-0.15]) 49. Conclusions Relevance In this veterans, scores likelihood developing events These results support utility health promotion prevention.

Language: Английский

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Predictive Value of Cardiovascular Health Score for Health Outcomes in Patients with PCI: Comparison between Life’s Simple 7 and Life’s Essential 8

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(4), P. 3084 - 3084

Published: Feb. 10, 2023

The American Heart Association recently published an updated algorithm for quantitative assessments of cardiovascular health (CVH) metrics, namely Life's Essential 8 (LE8). This study aimed to compare the predictive value between Simple 7 (LS7) and LE8 predict likelihood major adverse cardiac events (MACEs) in patients undergoing percutaneous coronary intervention (PCI) determine utility predicting CVH outcomes. A total 339 with acute syndrome (ACS) who had undergone PCI were enrolled assess scores using LS7 LE8. Multivariable Cox regression analysis was employed evaluate two different scoring systems at 2 years MACEs. revealed that both protective factors MACEs (HR = 0.857, [95%CI: 0.78-0.94], HR 0.964, 0.95-0.98]; p < 0.05, respectively). Receiver operator characteristic indicated area under curve (AUC) higher than (AUC: 0.662 vs. 0.615, 0.05). Lastly, score, diet, sleep health, serum glucose levels, nicotine exposure, physical activity found be correlated 0.985, 0.988, 0.993, 0.994, Our established is a more reliable assessment system CVH. population-based prospective reports unfavorable profile associated Future research warranted effectiveness optimizing reducing risk In conclusion, our findings corroborated provided further evidence association

Language: Английский

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Changes in Life’s Essential 8 and risk of cardiovascular disease in Chinese people

European Journal of Public Health, Journal Year: 2024, Volume and Issue: 34(4), P. 766 - 773

Published: April 4, 2024

Abstract Background The American Heart Association recently released an updated algorithm for evaluating cardiovascular health—Life’s Essential 8 (LE8). However, the associations between changes in LE8 score over time and risk of disease (CVD) remain unclear. Methods We investigated 6-year (2006–12) subsequent CVD events (2012–20) among 53 363 Chinese men women from Kailuan Study, who were free 2012. was calculated based on eight components: diet quality, physical activity, smoking status, sleep health, body mass index, blood lipids, glucose pressure. Multivariable-adjusted Cox proportional-hazards models used to estimate hazard ratios (HRs) 95% confidence intervals (CIs). Results documented 4281 incident cases during a median 7.7 years follow-up. Compared with participants whose scores remained stable period, those large increases period had lower CVD, heart stroke [HRs CIs: 0.67 (0.64, 0.70) 0.65 (0.61, 0.69) disease, 0.71 (0.67, 0.76) stroke, all Ptrend &lt; 0.001]. Conversely, decreases 47%, 51% 41% higher respectively. These consistent across subgroups stratified by factors. Conclusions Improving short- moderate-term associated risk, whereas decreased risk.

Language: Английский

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