Antioxidants,
Journal Year:
2022,
Volume and Issue:
12(1), P. 50 - 50
Published: Dec. 26, 2022
Aloe
plant
species
have
been
used
for
centuries
in
traditional
medicine
and
are
reported
to
be
an
important
source
of
natural
products.
However,
despite
the
large
number
within
genus,
only
a
few
investigated
chemotaxonomically.
A
Molecular
Network
approach
was
highlight
different
chemical
classes
characterizing
leaves
five
species:
macra,
vera,
tormentorii,
ferox,
purpurea.
A.
purpurea
endemic
from
Mascarene
Islands
comprising
Reunion,
Mauritius,
Rodrigues.
UHPLC-MS/MS
analysis
followed
by
dereplication
process
allowed
characterization
93
metabolites.
The
newly
developed
MolNotator
algorithm
usedfor
molecular
networking
better
exploration
metabolome
chemodiversity.
appeared
rich
polyphenols
(anthracene
derivatives,
flavonoids,
phenolic
acids).
Therefore,
total
content
antioxidant
activity
were
evaluated,
DPPH-On-Line-HPLC
assay
determine
metabolites
responsible
radical
scavenging
activity.
use
computational
tools
description
comparative
phytochemical
profiling
species,
which
showed
differences
their
metabolite
composition,
both
qualitative
quantitative.
Moreover,
network
combined
with
On-Line-HPLC
identification
9
Two
them,
aloeresin
coumaroylaloesin,
could
principal
From
374
calculated
MolNator,
characterized.
can
new
structures
that
need
discovered.
Phytotherapy Research,
Journal Year:
2022,
Volume and Issue:
36(2), P. 873 - 890
Published: Jan. 17, 2022
Abstract
The
Aloe
species
is
known
for
its
medicinal
and
cosmetic
properties.
Aloin
an
active
ingredient
found
in
the
leaves
of
plants
genus
.
has
attracted
considerable
interest
antiinflammatory,
anticancer,
antibacterial,
antioxidant
activities.
However,
since
clinical
application
restricted
by
unclear
mechanism
action,
a
deeper
understanding
pharmacological
activity
required.
This
review
provides
overview
current
toxicological
studies
published
English
from
February
2000
to
August
2021.
Herein,
we
summarized
sources
potential
health
benefits
aloin
perspective
guide
further
on
aloin,
aimed
at
efficiently
increasing
production.
Importantly,
function
action
remain
unclarified.
In
future
research,
it
necessary
develop
new
approaches
studying
molecular
mechanisms
underlying
this
compound
against
various
diseases.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(11), P. 6276 - 6276
Published: June 3, 2022
Skin
cancer
(melanoma
and
non-melanoma)
is
the
most
frequent
type
of
malignancy
in
Caucasian
population.
Photodynamic
therapy
(PDT)
as
an
interesting
unique
strategy
may
potentially
boost
standard
therapeutic
approaches.
In
present
study,
potential
emodin
aloe-emodin
photosensitizers
photodynamic
has
been
investigated.
The
conducted
research
presents
for
first-time
comparison
phototoxic
anti-cancerous
effects
on
skin
cell
lines,
including
SCC-25
representing
cutaneous
squamous
carcinoma,
MUG-Mel2
a
melanoma
line,
normal
human
keratinocytes
HaCaT
control
cells.
To
assess
effectiveness
photosensitizer
PDT
different
we
performed
MTT
assay
measuring
cytotoxicity
natural
compounds,
cellular
uptake,
apoptosis
with
flow
cytometry,
wound-healing
assay.
Although
are
isomers
differ
only
position
one
hydroxyl
group,
our
phototoxicity
detection
results
show
that
both
substances
affect
cells
(SSC-25
carcinoma
melanoma)
(HaCaT
line)
other
ways.
conclusion,
study
provides
evidence
suggesting
mediated
exhibits
clinical
development
new
effective
safe
to
treat
cancer.
Arabian Journal of Chemistry,
Journal Year:
2021,
Volume and Issue:
14(12), P. 103449 - 103449
Published: Sept. 22, 2021
•
2-methylindole
analogs
were
designed,
synthesized
and
characterized.
The
target
(
4a–4j
)
evaluated
for
their
inhibitory
potential
against
glutathione
S-transferase
(GST),
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE)
activities.
Molecular
docking
studies
conducted
to
correlate
the
in
vitro
results
identify
possible
mode
of
interactions
at
active
pocket
site
receptors.
pharmacokinetic
carried
out
using
SwissADMET
analyses.
In
this
study,
we
aimed
(i)
synthesize
new
containing
various
amino
structures,
pyrrolidine,
piperidine,
morpholine,
substituted
phenyl
groups
through
structural
molecular
modifications,
(ii)
evaluate
pharmaceutical
via
assessing
enzyme
activity
(BChE),
(iii)
predict
ADMET
properties
analogs,
(iv)
reveal
between
with
GST,
AChE,
BChE
enzymes
several
software.
inhibition
assays
showed
that
indole
exhibited
moderate
good
activities
enzymes.
Briefly,
4b
4i
4a
BChE,
1
GST
detected
be
higher
or
close
standard
inhibitor
compounds.
analog
was
have
best
both
AChE
lowest
IC
50
values
as
0.648
µM
0.745
BChE.
analyses
relationship
could
help
design
inhibitors
cholinergic
pathways
based
on
derivatives.
Journal of drug targeting,
Journal Year:
2020,
Volume and Issue:
29(4), P. 349 - 364
Published: Nov. 19, 2020
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
appeared
in
2019
and
is
the
causative
agent
of
new
pandemic
viral
disease
COVID-19.
The
outbreak
COVID-19
infection
affecting
entire
world,
thus
many
researchers
scientists
are
desperately
looking
for
suitable
vaccines
treatment
options.
Indeed,
researches
to
find
potential
inhibitors
SARS-CoV-2
mainly
focussed
on
targeting
virus-host
interactions
or
inhibiting
assembly.
Additionally,
drugs
other
therapeutic
agents
that
modulate
broad-spectrum
host
innate
immune
responses
interfere
with
signalling
pathways
involved
replication
important.
These
may
be
capable
engaging
receptors
proteases
utilised
entry
impact
endocytosis
pathway.
3CLpro
(3-chymotrypsin-like
protease),
PLpro
(papain-like
RdRp
(RNA-dependent
RNA
polymerase),
S
protein
(viral
spike
glycoprotein),
TMPRSS2
(transmembrane
protease
serine
2),
ACE2
(angiotensin-converting
enzyme
AT2
(angiotensin
receptor)
important
targets.
With
no
approved
therapies,
this
illustrates
urgent
need
safe
antiviral
strategies
against
future
pathogenic
viruses.
In
review,
we
discussed
about
recent
trends
challenges
regarding
inhibitors,
nanomaterials
screened
SARS-CoV-2.
Journal of Complementary and Alternative Medical Research,
Journal Year:
2020,
Volume and Issue:
unknown, P. 10 - 22
Published: Sept. 26, 2020
Aim:
Till
now,
no
specific
treatment
is
available
for
COVID-19.
This
work
carried
out
with
the
aim
of
verifying
in
literature
antiviral
properties
aromatic
plants
and
essential
oils
that
can
justify
their
use
against
causative
agent
COVID-19,
SARS-CoV-2.
Methodology:
The
review
was
based
mainly
on
usual
databases
such
as
PubMed,
PubMed
Central.,
Science
Direct,
SCIELO,
DOAJ,
alert,
Semantic
scholar
Google
scholar.
Results:
A
survey
reveals
are
active
a
large
number
viruses
(Herpes
virus-1,
Herpes
virus-2,
HIV,
Adeno
virus,
Hepatite
B
Virus,
Enterovirus
71,
JUNV,
etc.)
even
SARS-CoV-1
which
has
96%
same
genetic
background
Conclusion:
Aromatic
exhibit
high
activities
several
types
viruses.
evidence
stemming
from
experimental
studies
means
some
compounds
derived
could
act
inhibitors
COVID-19.
Molecular
docking
investigations
pharmacoinformatics
SARS-CoV-2
protease
progress
to
identify
potential
virus.
