Journal of Natural Medicines, Journal Year: 2021, Volume and Issue: 76(1), P. 20 - 37
Published: Oct. 8, 2021
Language: Английский
MedComm, Journal Year: 2022, Volume and Issue: 3(3)
Published: July 14, 2022
The main proteases (M
Language: Английский
Citations
149
Journal of Ethnobiology and Ethnomedicine, Journal Year: 2021, Volume and Issue: 17(1)
Published: April 8, 2021
Abstract Background Medicinal plants are the fundamental unit of traditional medicine system in Nepal. Nepalese people rich especially folk (ethnomedicine), and this is gaining much attention after 1995. The use medicinal has increased during COVID-19 pandemic as a private behavior (not under control government). A lot misinterpretations to treat or prevent have been spreading throughout Nepal which need be managed proactively. In context, research was needed document used, their priority society, cultivation status, source information follow them. This study aimed present status plant make important suggestion concerned authorities. Methods used web-based survey collect primary data related COVID-19. total 774 respondents took part survey. calculated relative frequencies citation (RFC) for recorded plants. relationship between different covariates (age, gender education, occupation, living place, treatment methods) assessed using Kruskal-Wallis test Wilcoxon test. sources respondent characteristics chi-square Results found that most recommended 60 belonging 36 families. leaves were frequently used. Zingiber officinale cited species with frequency 0.398. Most (45.61%) getting from home garden. significantly associated education level, location home, mode, gender, age class. method treatment, family, lockdown caused by Conclusions People more claiming they can cure should taken seriously authorities validity these flow false spread through awareness programs.
Language: Английский
Citations
125
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 147, P. 112658 - 112658
Published: Jan. 20, 2022
The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more than three hundred million individuals and resulted in five deaths worldwide. ongoing pandemic underscored urgent need for effective preventive therapeutic measures to develop anti-viral therapy. natural compounds possess various pharmaceutical properties are reported as anti-virals. interest an drug against novel severe acute respiratory syndrome (SARS-CoV-2) from increased globally. Here, we investigated potential selected promising products. Sources data this paper current literature published context uses phytoconstituents their mechanism action reputed peer-reviewed journals. An extensive survey was done were critically analyzed get deeper insights into a few important phytoconstituents. consumption products such thymoquinone, quercetin, caffeic acid, ursolic ellagic vanillin, thymol, rosmarinic acid could improve our immune response thus possesses excellent potential. This review focuses on functions phytoconstituent alkaloids implications SARS-CoV-2. Our comprehensive analysis provides mechanistic restrain viral infection provide better solution through natural, therapeutically active agents.
Language: Английский
Citations
76
PLoS ONE, Journal Year: 2021, Volume and Issue: 16(9), P. e0257165 - e0257165
Published: Sept. 22, 2021
The burden of the COVID-19 pandemic in Peru has led to people seeking alternative treatments as preventives and treatment options such medicinal plants. This study aimed assess factors associated with use plants preventive or respiratory symptom related during Cusco, Peru.
Language: Английский
Citations
93
Microbiology Insights, Journal Year: 2021, Volume and Issue: 14
Published: Jan. 1, 2021
After the outbreak of SARS and MERS, world is now in grip another viral disease named COVID-19 caused by a beta Coronavirus - COV-2 which appears to be only one with pandemic potential. The case was reported Hubei province Wuhan city Central China at end December 2019 it suspected that sea food market played role this closed abruptly. Subsequently, Public Health Emergency International Concern declared on 30 January 2020 World Organization. Both MERS corona viruses had its reservoir bats were transferred humans from palm civets camels respectively. This virus can transmitted through airborne droplets. Natural intermediate host yet identified. paper reviews occurrences diseases recent times including MERS. As an addition this, will contain detailed examination Pandemic.
Language: Английский
Citations
72
Pharmaceuticals, Journal Year: 2021, Volume and Issue: 14(3), P. 213 - 213
Published: March 4, 2021
The emergence of the SARS-CoV-2 pandemic has prompted scientists to search for an efficient antiviral medicine overcome rapid spread and marked increase in number patients worldwide. In this regard natural products could be a potential source substances active against coronavirus infections. A systematic computer-aided virtual screening approach was carried out using commercially available found on Zinc Database addition in-house compound library identify product inhibitors main protease (MPRO). top eighteen hits from were selected vitro evaluation viral (SARS-CoV-2 MPRO). Five compounds (naringenin, 2,3′,4,5′,6-pentahydroxybenzophenone, apigenin-7-O-glucoside, sennoside B, acetoside) displayed high activity protein. Acteoside showed similar positive control GC376. most potent tested Egyptian strain where only naringenin moderate anti-SARS-CoV-2 at non-cytotoxic micromolar concentrations with significant selectivity index (CC50/IC50 = 178.748/28.347 6.3). Moreover; common feature pharmacophore model generated explain requirements enzyme inhibition by diverse group ligands. These results pave path future repurposing development aid battle COVID-19.
Language: Английский
Citations
58
Frontiers in Medicine, Journal Year: 2020, Volume and Issue: 7
Published: Dec. 11, 2020
Background: During the COVID-19 pandemic people are facing risks of adverse health effects due to restrictions implemented such as quarantine measures, reduced social contact, and self-isolation. In this qualitative review, we collected data on potential preventive therapeutic benefits Complementary Integrative Medicine (CIM) that might be useful during pandemic. We have reviewed scientific literature summarize CIM practices could beneficial for improving physical mental well-being population under current circumstances. It must noted review is not SARS-CoV-2 specific explicitly do intend make any claims in article. Methods Findings: A qualitative, non-systematic was conducted Medline identify describing approaches strengthening health. For a variety clinical evidence identified, indicating effects. include dietary measures selected micronutrients, activity, techniques from Mind-Body Medicine, single botanicals or botanical compounds, spending time nature among others. The conditions like obesity hypertension special relevance here, these considered risk factors severe course COVID-19. Moreover, possibly direct effect immune functions parameters respiratory tract infections, influenza, were identified. findings helpful clinicians, patients, general when discussing and/or considering options. Conclusions: offers options resilience, which also with benefit different areas worth analyzed. While has several obvious limitations, it serve starting point further research topic.
Language: Английский
Citations
59
Journal of Science Advanced Materials and Devices, Journal Year: 2021, Volume and Issue: 6(3), P. 407 - 414
Published: May 20, 2021
COVID-19 belongs to a typical class of viruses that predominantly affects the human respiratory system, thereby proving be fatal many. The virus, along with other air pollutant particulates poses severe threat organs. Since most common transmission mode is fomites and aerosol particulates, it necessary prevent their ingression through mask. primary use masks aerial particulates. This paper reveals development filters coated functionalized graphene (fG) mounted on 3D-printed facial mask replica. fused deposition modeling (FDM) process used for fabricating fG associated nanosheets has an additional adsorbing capacity high surface area volume ratio. coat over polypropylene (PP) cloth dip coating method enhance antiviral antimicrobial properties. quality was investigated Raman spectroscopy characterization techniques such as SEM, XRD, FTIR, which were visual interpretation distributions fabric. Fabricated MB show 98.2% bacterial filtration efficiency 1.10 mbar breathing resistance. efficacy filter tested against SARS-CoV-2 viral particles, showed complete arrest at layer.
Language: Английский
Citations
51
Journal of Traditional and Complementary Medicine, Journal Year: 2022, Volume and Issue: 12(1), P. 100 - 113
Published: Jan. 1, 2022
The management of the worldwide spreading COVID-19 consists amelioration its symptoms but no cure is yet available. Herbal medicines supplemented with Western medicine have been applied for treatment in India, China, Iran, and other countries. This systematic review meta-analysis RCTs evaluates effect safety herbal intervention COVID-19. from databases like PubMed, Cochrane Library, ScienceDirect, Google Scholar, Science Direct, CTRI, AYUSH Research Portal, were reviewed data extracted study sample demographics, details, clinical effect, inflammatory markers monitoring. Outcomes expressed as Risk-ratio (RR) 95% CI dichotomous data, Mean-Difference (MD) continuous data. From 32 eligible studies, a total 3177 patients included review. an adjuvant to causes significantly higher improvement compared alone [Fever (RR = 1.09 1.03, 1.15), Cough (Risk-Ratio 1.22 1.08, 1.37), Fatigue 1.27 1.11, 1.44), Chest CT Improvement 1.15 1.23)]. laboratory parameters also better group standard care only WBC (MD 0.36 0.16, 0.55), Lymphocyte percentage 5.48 3.05, 7.92), Absolute lymphocyte count 0.23 0.07, 0.39), CRP −5.66 -7.96, −3.37). However, duration hospital stays −1.82 -3.84, 0.21); IL-6 −3.67 -8.76, 1.43), ESR Level −10.38 -25.96, 5.21) statistically insignificant. No significant adverse events medications noted RCTs, during time studies. (n 665, RR 0.93; 0.76, 1.14).
Language: Английский
Citations
38
Narra J, Journal Year: 2022, Volume and Issue: 2(3), P. e92 - e92
Published: Dec. 9, 2022
he emergence of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has affected many countries throughout the world. As urgency is a necessity, most efforts have focused on identifying small molecule drugs that can be repurposed for use as anti-SARS-CoV-2 agents. Although several drug candidates been identified using
Language: Английский
Citations
36