Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: March 10, 2022

Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA its derivatives have been used for many centuries due to their natural healing medicinal properties. possesses various biological pharmacological activities, including antioxidant, anti-inflammatory, anticancer, neuroprotective effects. The potential therapeutic effects of are mediated via repression inhibition transcription growth factors. anticancer human cell cultures animal models. However, the biomolecular interactions pathways described highlighting target binding proteins signaling molecules. current review focuses on CA’s chemical, physical, properties, We further characteristics future directions.

Language: Английский

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Biomedical features and therapeutic potential of rosmarinic acid

Archives of Pharmacal Research, Journal Year: 2022, Volume and Issue: 45(4), P. 205 - 228

Published: April 1, 2022

Language: Английский

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Understanding of Alzheimer's Disease Pathophysiology for Therapeutic Implications of Natural Products as Neuroprotective Agents

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102680 - 102680

Published: Feb. 1, 2025

Language: Английский

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Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: March 25, 2022

Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of cancer cases. EGFR is involved in several developments, including NSCLC. The pathway regulates the Bax/Bcl-2 cascade Increasing understanding molecular mechanisms fundamental tumor progression has guided development numerous antitumor drugs. and improvement rationally planned inhibitors agents targeting particular cellular biological pathways have been signified as a most important paradigm shift strategy to treat manage cancer. Newer approaches novel chemotherapeutic are required accompany present therapies for improving efficiency. Using natural products drug with an effective delivery system may benefit therapeutics. Naturally originated compounds such phytochemicals provide crucial sources agents/drugs resources therapy. Applying small-molecule (SMIs)/phytochemicals led potent preclinical discoveries various human models, In this review, we summarize recent information on NSCLC target them therapeutic implications. We further described potential Bax/Bcl-2/EGFR SMIs, mainly those more selectivity, gefitinib, EGCG, ABT-737, thymoquinone, quercetin, venetoclax. addition, explained ongoing vitro vivo clinical investigations Exploration facilitates future treatment management

Language: Английский

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Recent advances in the therapeutic potential of emodin for human health

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113555 - 113555

Published: Aug. 23, 2022

Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a bioactive compound, natural anthraquinone aglycone, present mainly in herbaceous species of the families Fabaceae, Polygonaceae and Rhamnaceae, with physiological role protection against abiotic stress vegetative tissues. used traditional Chinese medicine to treat sore throats, carbuncles, sores, blood stasis, damp-heat jaundice. Pharmacological research last decade has revealed other potential therapeutic applications such as anticancer, neuroprotective, antidiabetic, antioxidant anti-inflammatory. The study aimed summarize recent studies on bioavailability, preclinical pharmacological effects evidence molecular mechanisms, clinical trials pitfalls, respectively limitations emodin. For this purpose, extensive searches were performed using PubMed/Medline, Scopus, Google scholar, TRIP database, Springer link, Wiley SciFinder databases search engines. vitro vivo included updated review highlighted signaling pathways mechanisms Because its bioavailability low, there are use. In conclusion, for an increase pharmacotherapeutic efficacy, future carrier molecules target, thus opening up new perspectives.

Language: Английский

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Utilisation of Mangifera indica plant extracts and parts in antimicrobial formulations and as a pharmaceutical excipient: a review

Future Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 9(1)

Published: April 5, 2023

Abstract Background Antimicrobial resistance and the environmental threat posed by some synthetic antimicrobial agents necessitate more research into development of novel pharmaceutical products that are environmentally friendly. Also, use plant derived excipients is growing opening up new avenue to solve current drug delivery issues in industry. Main body This review summarizes studies related property Mangifera indica extracts, possible mechanisms action formulations from overview researches relating M. as a excipient. Electronic searches were conducted on databases such Pub Med, Wiley Online Library (WOL) Google Scholar with focus published articles . Inclusion exclusion criteria include publications properties its The electronic yielded about 190 articles. From reviewed, phytochemicals described corroborate activity exhibited extracts selected formulations. In addition, mango pectin was observed possess potential Very few previous based their incorporating mechanism activity. examined formulations, major parts modes action. study assessed natural polymer pharmacological preparations. Conclusion concluded effective requires synergy actions among various phytochemical constituents extract or formulation. It recommended focused discovery indica, utilization industry should be further explored.

Language: Английский

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Investigating regulated signaling pathways in therapeutic targeting of non-small cell lung carcinoma

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114452 - 114452

Published: March 3, 2023

Non-small cell lung carcinoma (NSCLC) is the most common malignancy worldwide. The signaling cascades are stimulated via genetic modifications in upstream molecules, which affect apoptotic, proliferative, and differentiation pathways. Dysregulation of these causes cancer-initiating proliferation, cancer development, drug resistance. Numerous efforts treatment NSCLC have been undertaken past few decades, enhancing our understanding mechanisms development moving forward to develop effective therapeutic approaches. Modifications transcription factors connected pathways utilized new options for NSCLC. Developing designed inhibitors targeting specific cellular tumor progression has recommended management This comprehensive review provided deeper mechanistic insights into molecular mechanism action various molecules their clinical

Language: Английский

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Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114710 - 114710

Published: May 3, 2023

α-Mangostin (α-MG) is a natural xanthone obtained from the pericarps of mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective, antimicrobial, antioxidant, and anti-inflammatory properties, induces apoptosis. α-MG controls cell proliferation by modulating signaling molecules, thus implicated in cancer therapy. possesses incredible pharmacological features modulates crucial cellular molecular factors. Due to its lesser water solubility pitiable target selectivity, has limited clinical application. As known gained significant attention scientific community, increasing interest extensive technical biomedical applications. Nanoparticle-based drug delivery systems were designed improve efficiency α-MG. This review focused on recent developments therapeutic potential managing neurological diseases, with special focus mechanism action. In addition, we highlighted biochemical features, metabolism, functions, anti-inflammatory, antioxidant effects pre-clinical applications

Language: Английский

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The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1345 - 1345

Published: April 29, 2024

This review aims to evaluate the efficacy of any vitamin administration(s) in preventing and managing COVID-19 and/or long-COVID. Databases were searched up May 2023 identify randomized clinical trials comparing data on effects supplementation(s) versus placebo or standard care two conditions interest. Inverse-variance random-effects meta-analyses conducted estimate pooled risk ratios (RRs) 95% confidence intervals (CIs) for all-cause mortality between supplemented non-supplemented individuals. Overall, 37 articles included: regarded long-COVID prevention 35 records management. The D contrasting. Similarly, no conclusion could be drawn multivitamins, A, B A few positive findings reported some C but results inconsistent most outcomes, excluding (RR = 0.84; CI: 0.72–0.97). Vitamin mixed aspects, including mortality, which benefits observed regular administrations only 0.67; 0.49–0.91). Despite benefits, mostly contradictory. Variety recruitment treatment protocols might explain this heterogeneity. Better-designed studies are needed clarify these vitamins’ potential against SARS-CoV-2.

Language: Английский

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Evaluation of the Potency of Repurposed Antiretrovirals in HBV Therapy: A Narrative Investigation of the Traditional Medicine Alternatives

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1523 - 1523

Published: Feb. 11, 2025

Hepatitis B is one of the killer communicable diseases, with a global estimation 1.1 million deaths resulting from liver diseases annually. The search for HBV therapeutics has resulted in repurposing existing antiretrovirals (ARVs) treatment, considering their shared common replication mechanisms. This review aimed at evaluating potencies some repurposed ARVs used analyzing mechanisms viral replications and HIV, investigating potentials traditional medicines as an alternative treatment patients. topical keywords drug repurposing, repositioning, antiretrovirals, hepatitis HBV, natural products, medicines, title, abstract were searched PubMed, Web Science, Google Scholar. advanced included five years, 2019-2024. result was filtered 377 to 110 relevant articles. evaluation reveals that CD4+ T cells are targeted by while targets its associated (cirrhosis hepatocellular carcinoma (HCC)). Furthermore, treatments available only prevent or slow down progression cirrhosis, reduce HCC incidence, can improve quality life increase expectancy; however, they not curative HBV. Traditional medicines/natural product extracts phytochemicals exert anti-HBV effects through different improved therapeutic when combined properly. investigation further consideration silico approach might streamline development but also contribute deeper understanding pathogenesis. Therefore, we recommend integration computational design methods medicine screening discovering new bioactive candidates.

Language: Английский

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