Cell, Journal Year: 2020, Volume and Issue: 184(2), P. 507 - 520.e16
Published: Dec. 30, 2020
Language: Английский
eLife, Journal Year: 2020, Volume and Issue: 9
Published: April 21, 2020
The Drosophila ventral nerve cord (VNC) receives and processes descending signals from the brain to produce a variety of coordinated locomotor outputs. It also integrates sensory information periphery sends ascending brain. We used single-cell transcriptomics generate an unbiased classification cellular diversity in VNC five-day old adult flies. produced atlas 26,000 high-quality cells, representing more than 100 transcriptionally distinct cell types. predominant gene signatures defining neuronal types reflect shared developmental histories based on neuroblast which cells were derived, as well their birth order. relative position along anterior-posterior axis could be assigned using Hox expression. This transcriptional fly will valuable resource for future studies neurodevelopment behavior.
Language: Английский
Citations
151
Neuron, Journal Year: 2014, Volume and Issue: 83(1), P. 135 - 148
Published: July 1, 2014
Language: Английский
Citations
171
Current Opinion in Neurobiology, Journal Year: 2016, Volume and Issue: 38, P. 18 - 26
Published: March 3, 2016
Language: Английский
Citations
159
Current Biology, Journal Year: 2015, Volume and Issue: 25(20), P. 2621 - 2630
Published: Sept. 24, 2015
Language: Английский
Citations
130
Current Biology, Journal Year: 2016, Volume and Issue: 26(11), P. 1395 - 1403
Published: May 12, 2016
Language: Английский
Citations
126
Current Biology, Journal Year: 2015, Volume and Issue: 25(6), P. 790 - 797
Published: Feb. 19, 2015
Language: Английский
Citations
106
eLife, Journal Year: 2018, Volume and Issue: 7
Published: Feb. 2, 2018
To optimize fitness, animals must dynamically match food choices to their current needs. For drosophilids, yeast fulfills most dietary protein and micronutrient requirements. While several metabolites activate known gustatory receptor neurons (GRNs) in Drosophila melanogaster, the chemosensory channels mediating feeding remain unknown. Here we identify a class of proboscis GRNs required for intake. Within this class, taste peg are specifically sustain feeding. Sensillar GRNs, however, mediate initiation. Furthermore, response but not sweet is enhanced following deprivation from amino acids, providing potential basis protein-specific appetite. Although nutritional reproductive states synergistically increase appetite, state acts independently state, modulating processing downstream GRNs. Together, these results suggest that different internal act at distinct levels dedicated circuit elicit nutrient-specific appetites towards complex, ecologically relevant source.
Language: Английский
Citations
104
Annual Review of Neuroscience, Journal Year: 2017, Volume and Issue: 40(1), P. 327 - 348
Published: April 25, 2017
Animals are born with a rich repertoire of robust behaviors that critical for their survival. However, innate also highly adaptable to an animal's internal state and external environment. Neuromodulators, including biogenic amines, neuropeptides, hormones, released signal changes in animals' circumstances serve reconfigure neural circuits. This circuit flexibility allows animals modify behavioral responses according environmental cues, metabolic demands, physiological states. Aided by powerful genetic tools, researchers have made remarkable progress Drosophila melanogaster address how myriad contextual information influences the input-output relationship hardwired circuits support complex repertoire. Here we highlight recent advances understanding neuromodulation behaviors, special focus on feeding, courtship, aggression, postmating behaviors.
Language: Английский
Citations
103
Current Biology, Journal Year: 2014, Volume and Issue: 24(14), P. 1584 - 1595
Published: July 1, 2014
BackgroundFemale sexual receptivity offers an excellent model for complex behavioral decisions. The female must parse her own reproductive state, the external environment, and male sensory cues to decide whether copulate. In fly Drosophila melanogaster, virgin has received relatively little attention, its neural circuitry individual components remain unmapped. Using a genome-wide neuronal RNAi screen, we identify subpopulation of neurons responsible pausing, novel aspect characterized in this study.ResultsWe show that Abdominal-B (Abd-B), homeobox transcription factor, is required developing high levels receptivity. Silencing adult Abd-B significantly decreased We characterize two are elicited sexually mature females by courtship: pausing vaginal plate opening. but did not affect opening, demonstrating these behavior functionally separable. Synthetic activation increased courtship song alone was sufficient elicit behavior.ConclusionsOur results provide entry point circuit controlling integrates multiple from execute discrete motor programs prior copulation. control key receptivity, response courtship.
Language: Английский
Citations
100
Briefings in Functional Genomics, Journal Year: 2015, Volume and Issue: 14(6), P. 396 - 406
Published: March 22, 2015
In recent years, our knowledge of the conserved master-switch gene doublesex (dsx) and its function in regulating development dimorphic traits insects has deepened considerably. Here, a comprehensive overview is given on properties male- female-specific dsx transcripts yielding DSXF DSXM proteins Drosophila melanogaster, many downstream targets that they regulate. As have cell-autonomous sex determination, it was assumed would be expressed every somatic cell, but research showed only when cell required to show sexual identity through or morphology. This spatiotemporal regulation expression not been established D. melanogaster all insect species studied. Gradually, appreciated could no longer viewed as orchestrating behaviour each instead should interpreter for expressing this request, making central nexus determination.
Language: Английский
Citations
98