Organization of the catecholaminergic systems in the brain of lungfishes, the closest living relatives of terrestrial vertebrates DOI
Jesús M. López, Agustı́n González

The Journal of Comparative Neurology, Journal Year: 2017, Volume and Issue: 525(14), P. 3083 - 3109

Published: June 26, 2017

Abstract Lungfishes are a group of sarcopterygian fishes currently considered the closest living relatives tetrapods, and represent an interesting for study evolutionary traits in transition from to tetrapods. Catecholaminergic systems brain among most carefully analyzed neurotransmitter vertebrate groups. Their organization shows major shared characteristics, although particular each class have also been found, primarily between anamniotes amniotes. Given relevance lungfishes terms, present provides first comprehensive detailed map catecholaminergic structures two representative species lungfishes, African lungfish ( Protopterus dolloi ) Australian Neoceratodus forsteri ), as revealed by immunohistochemistry. Distinct groups cells were observed olfactory bulb, pallium, preoptic area telencephalon, subpallium is devoid these cells. Hypothalamic diencephalic detected and, particular, dopaminergic nucleus periventricular organ was evidenced with dopamine antibodies but not anti‐tyrosine hydroxylase. A well developed mesostriatal system formed conspicuous midbrain tegmentum profuse innervation subpallium. Comparison results those other classes vertebrates numerous common highlights features different actinopterygian that resemble amphibians

Language: Английский

Zebrafish Larvae Behavior Models as a Tool for Drug Screenings and Pre-Clinical Trials: A Review DOI Open Access
João Gabriel Santos Rosa, Carla Lima, Mônica Lopes‐Ferreira

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(12), P. 6647 - 6647

Published: June 14, 2022

To discover new molecules or review the biological activity and toxicity of therapeutic substances, drug development, research relies on robust systems to obtain reliable results. Phenotype-based screenings can transpose organism’s compensatory pathways by adopting multi-target strategies for treating complex diseases, zebrafish emerged as an important model biomedical screenings. Zebrafish’s clear correlation between neuro-anatomical physiological features behavior is very similar that verified in mammals, enabling construction relevant experimental models neurological disorders research. Zebrafish presents highly conserved are found higher vertebrates, including along with a behavioral repertoire. Moreover, it sensitive pharmacological/environmental manipulations, these phenotypes detected both larvae adults. These advantages align 3Rs concept qualify powerful tool pre-clinical trials. This highlights domains studied their neurotransmitter summarizes currently used techniques evaluate quantify laboratory studies.

Language: Английский

Citations

102
Controlled delivery of a neurotransmitter–agonist conjugate for functional recovery after severe spinal cord injury DOI

Yanming Zuo,

Jingjia Ye, Wanxiong Cai

et al.

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(10), P. 1230 - 1240

Published: June 12, 2023

Language: Английский

Citations

51
The Zebrafish Visual System: From Circuits to Behavior DOI
Johann H. Bollmann

Annual Review of Vision Science, Journal Year: 2019, Volume and Issue: 5(1), P. 269 - 293

Published: Sept. 15, 2019

Visual stimuli can evoke complex behavioral responses, but the underlying streams of neural activity in mammalian brains are difficult to follow because their size. Here, I review visual system zebrafish larvae, highlighting where recent experimental evidence has localized functional steps visuomotor transformations specific brain areas. The retina a larva encodes behaviorally relevant information distributed across feature-selective ganglion cells such that signals representing distinct stimulus properties arrive different areas or layers brain. Motor centers hindbrain encode motor variables precisely tuned needs within given setting. Owing rapid technological progress, larval provide unique opportunities for obtaining comprehensive understanding intermediate processing occurring between and centers, revealing how implemented vertebrate

Language: Английский

Citations

99
A Critical Role for Dopamine D5 Receptors in Pain Chronicity in Male Mice DOI Creative Commons
Salim Megat, Stephanie Shiers, Jamie K. Moy

et al.

Journal of Neuroscience, Journal Year: 2017, Volume and Issue: 38(2), P. 379 - 397

Published: Nov. 22, 2017

Dopaminergic modulation of spinal cord plasticity has long been recognized, but circuits affected by this system and the precise receptor subtypes involved in have not defined. from A11 nucleus hypothalamus contributes to a model chronic pain called hyperalgesic priming. Here we tested hypothesis that key subtype mediating effect is D5 (D5R). We find spinally directed lesion dopaminergic neurons reverses priming both sexes D1/D5 antagonist transiently inhibits neuropathic pain. used mice lacking D5Rs ( DRD5KO mice) show carrageenan, interleukin 6, as well BDNF-induced hyperalgesia are reduced specifically male mice. These also formalin responses decreased heat To characterize dorsal horn engaged dopamine signaling model, c-fos labeling. mixed agonist given primed activates subset lamina III IV coexpress PAX2, transcription factor for GABAergic interneurons. In line with this, gabazine, GABA-A antagonist, antihyperalgesic exposed administration agonist. Therefore, D5R, males, D1R, females, exert powerful influence over circuitry pathological likely via deep neurons. SIGNIFICANCE STATEMENT Pain most prominent reason why people seek medical attention, incidence worldwide estimated be high 33%. This study provides new insight into how descending controls states. Our work demonstrates projections necessary maintenance state sexes; however, receptors seem play critical role males whereas females rely more heavily on D1 receptors, an could explained sexual dimorphisms expression levels. Collectively, our insights interacts promote plasticity.

Language: Английский

Citations

73
The hypothalamic-spinal dopaminergic system: a target for pain modulation DOI Creative Commons
Michelino Puopolo

Neural Regeneration Research, Journal Year: 2019, Volume and Issue: 14(6), P. 925 - 925

Published: Jan. 1, 2019

Nociceptive signals conveyed to the dorsal horn of spinal cord by primary nociceptors are subject extensive modulation local neurons and supraspinal descending pathways before being relayed higher brain centers. Descending modulatory comprise, among others, noradrenergic, serotonergic, γ-aminobutyric acid (GABA)ergic, dopaminergic fibers. The contributions noradrenaline, serotonin, GABA pain have been extensively investigated. In contrast, dopamine remain poorly understood. focus this review is summarize current knowledge modulation. Hypothalamic A11 project all levels provide main source dopamine. Dopamine receptors expressed in as well located different laminae cord, suggesting that can modulate acting at both presynaptic postsynaptic targets. Here, I will literature on effects receptor agonists/antagonists excitability nociceptors, synaptic transmission between neurons, rodents. Published data support anti-nociceptive mediated D2-like pro-nociceptive D1-like receptors.

Language: Английский

Citations

63
Hypothalamic Dopamine Neurons Control Sensorimotor Behavior by Modulating Brainstem Premotor Nuclei in Zebrafish DOI Creative Commons
Joshua Barrios, Wei‐Chun Wang, Roman England

et al.

Current Biology, Journal Year: 2020, Volume and Issue: 30(23), P. 4606 - 4618.e4

Published: Oct. 1, 2020

Language: Английский

Citations

46
Parallel Channels for Motion Feature Extraction in the Pretectum and Tectum of Larval Zebrafish DOI Creative Commons
Kun Wang, Julian Hinz, Yue Zhang

et al.

Cell Reports, Journal Year: 2020, Volume and Issue: 30(2), P. 442 - 453.e6

Published: Jan. 1, 2020

Non-cortical visual areas in vertebrate brains extract relevant stimulus features, such as motion, object size, and location, to support diverse behavioral tasks. The optic tectum pretectum, two primary zebrafish, are involved motion processing, yet their differential neural representation of behaviorally features is unclear. Here, we characterize receptive fields (RFs) motion-sensitive neurons the diencephalon midbrain. We show that RFs many pretectal large sample lower field, whereas tectal mostly small-size selective upper nasal field more densely. Furthermore, optomotor swimming can reliably be evoked by presenting forward temporal alone, matching bias pretectum. Thus, pretectum different from distinct regions space, which likely a result adaptations hunting behavior, respectively.

Language: Английский

Citations

45
Rapid Effects of Selection on Brain-wide Activity and Behavior DOI Creative Commons
Carlos Pantoja, Johannes Larsch,

Eva Laurell

et al.

Current Biology, Journal Year: 2020, Volume and Issue: 30(18), P. 3647 - 3656.e3

Published: Aug. 6, 2020

Language: Английский

Citations

35
Conserved Genoarchitecture of the Basal Hypothalamus in Zebrafish Embryos DOI Creative Commons
Theresa Schredelseker, Wolfgang Driever

Frontiers in Neuroanatomy, Journal Year: 2020, Volume and Issue: 14

Published: Feb. 6, 2020

Analyses of genoarchitecture recently stimulated substantial revisions anatomical models for the developing hypothalamus in mammalian and other vertebrate systems. The prosomeric model proposes to be derived from secondary prosencephalon, consist alar basal regions. can further subdivided into tuberal mamillary regions, each with distinct subregions. Albeit being a widely used system neurodevelopmental studies, no detailed genoarchitectural maps exist zebrafish (Danio rerio) hypothalamus. Here, we compare expression domains genes, including arxa, shha, otpa, isl1, lhx5, nkx2.1, nkx2.2a, pax6 dlx5a, orthologs which delimit specific subregions within murine We develop highly conserved brain-specific homeobox (bsx) gene as novel marker analysis hypothalamic Our comparison patterns reveals that embryos 48 hours post fertilization is similar mouse at E13.5. found relatively large comprise previously ill-defined regions around posterior recess. smaller concentrates rather medial areas proximity anterior end neural tube floor plate. Within identified longitudinal transverse topologically equivalent those described vertebrates. However, diencephalic boundary region tuberculum still provide challenge. applied updated facilitate cross-species comparisons. Accordingly, nomenclature organization propose it replace some controversial previous nomenclature.

Language: Английский

Citations

33
Dense Circuit Reconstruction to Understand Neuronal Computation: Focus on Zebrafish DOI
Rainer W. Friedrich, Adrian Wanner

Annual Review of Neuroscience, Journal Year: 2021, Volume and Issue: 44(1), P. 275 - 293

Published: March 17, 2021

The dense reconstruction of neuronal wiring diagrams from volumetric electron microscopy data has the potential to generate fundamentally new insights into mechanisms information processing and storage in circuits. Zebrafish provide unique opportunities for dynamical connectomics approaches that combine reconstructions with measurements population activity behavior. Such have power reveal higher-order structure cannot be detected by sparse sampling connectivity is essential computations. In brain stem, recurrently connected modules were identified can account slow, low-dimensional dynamics an integrator circuit. spinal cord, specifies functional differences between premotor interneurons. olfactory bulb, tuning-dependent implements a whitening transformation based on selective suppression responses overrepresented stimulus features. These findings illustrate zebrafish analyze circuit underlying

Language: Английский

Citations

29