Sniff-synchronized, gradient-guided olfactory search by freely moving mice

eLife, Journal Year: 2021, Volume and Issue: 10

Published: May 4, 2021

For many organisms, searching for relevant targets such as food or mates entails active, strategic sampling of the environment. Finding odorous may be most ancient search problem that motile organisms evolved to solve. While chemosensory navigation has been well characterized in microorganisms and invertebrates, spatial olfaction vertebrates is poorly understood. We have established an olfactory assay which freely moving mice navigate noisy concentration gradients airborne odor. Mice solve this task using gradient cues do not require stereo performance. During performance, respiration nose movement are synchronized with tens milliseconds precision. This synchrony present during trials largely absent inter-trial intervals, suggesting sniff-synchronized a behavioral state rather than simply constant accompaniment fast breathing. To reveal spatiotemporal structure these active sensing movements, we used machine learning methods parse motion trajectories into elementary motifs. Motifs fall two clusters, correspond investigation approach states. Investigation motifs lock precisely sniffing, individual preferentially occur at specific phases sniff cycle. The allocentric indicates advantage both sides sharpest part odor gradient, consistent serial-sniff strategy sensing. work clarifies sensorimotor strategies mouse guides ongoing underlying neural mechanisms.

Language: Английский

---

Cortical processing of flexible and context-dependent sensorimotor sequences

Nature, Journal Year: 2022, Volume and Issue: 603(7901), P. 464 - 469

Published: March 9, 2022

Language: Английский

---

Spontaneous Rapid Odor Source Localization Behavior Requires Interhemispheric Communication

Current Biology, Journal Year: 2017, Volume and Issue: 27(10), P. 1542 - 1548.e4

Published: May 1, 2017

Language: Английский

---

Brainstem Circuits Controlling Action Diversification

Annual Review of Neuroscience, Journal Year: 2019, Volume and Issue: 42(1), P. 485 - 504

Published: July 8, 2019

Neuronal circuits that regulate movement are distributed throughout the nervous system. The brainstem is an important interface between upper motor centers involved in action planning and spinal cord ultimately leading to execution of body movements. Here we focus on recent work using genetic viral entry points reveal identity functionally dedicated frequently spatially intermingled populations essential for diversification, a general principle conserved evolution. Brainstem with distinct organization function control skilled forelimb behavior, orofacial movements, locomotion. They convey regulatory parameters output structures collaborate construction complex natural behaviors. Functionally tuned neurons different actions serve as integrators synaptic inputs from upstream centers, including basal ganglia cortex, modulate behavioral contexts.

Language: Английский

---

Body language signals for rodent social communication

Current Opinion in Neurobiology, Journal Year: 2021, Volume and Issue: 68, P. 91 - 106

Published: Feb. 11, 2021

Integration of social cues to initiate adaptive emotional and behavioral responses is a fundamental aspect animal human behavior. In humans, communication includes prominent nonverbal components, such as touch, gestures facial expressions. Comparative studies investigating the neural basis in rodents has historically been centered on olfactory signals vocalizations, with relatively less focus non-verbal cues. Here, we outline two exciting research directions: First, will review recent observations pointing role expressions rodents. Second, that point 'non-canonical' rodent body language: posture beyond stereotyped displays aggressive sexual both sections, how neuroscience can build advances machine learning, robotics micro-engineering push these directions forward towards holistic systems neurobiology language.

Language: Английский

---

The deep and slow breathing characterizing rest favors brain respiratory-drive

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: March 29, 2021

Abstract A respiration-locked activity in the olfactory brain, mainly originating mechano-sensitivity of sensory neurons to air pressure, propagates from bulb rest brain. Interestingly, changes nasal airflow rate result reorganization response. By leveraging spontaneous variations respiratory dynamics during natural conditions, we investigated whether drive also varies with movements. We analyzed local field potential relative signal various brain regions waking and sleep states. found that respiration regime was state-specific, quiet only vigilance state which all recorded structures can be respiration-driven whatever frequency. Using CO 2 -enriched alter associated each a cycle based analysis, evidenced large strong observed related an optimal trade-off between depth duration inspiration pattern, characterizing this specific state. These results show for first time affect cortical is

Language: Английский

---

Respiration aligns perception with neural excitability

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Dec. 14, 2021

Recent studies from the field of interoception have highlighted link between bodily and neural rhythms during action, perception, cognition. The mechanisms underlying functional body-brain coupling, however, are poorly understood, as ways in which they modulate behavior. We acquired respiration human magnetoencephalography data a near-threshold spatial detection task to investigate trivariate relationship respiration, excitability, performance. Respiration was found significantly perceptual sensitivity well posterior alpha power (8–13 Hz), well-established proxy cortical excitability. In turn, suppression prior detected versus undetected targets underscored behavioral benefits heightened Notably, respiration-locked excitability changes were maximized at phase lag around –30° thus temporally preceded performance changes. line with interoceptive inference accounts, these results suggest that actively aligns sampling sensory information transient cycles facilitate

Language: Английский

---

Active tactile discrimination is coupled with and modulated by the cardiac cycle

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Oct. 12, 2022

Perception and cognition are modulated by the phase of cardiac signal in which stimuli presented. This has been shown locking presentation to distinct phases. However, everyday life sensory information is not presented this passive phase-locked manner, instead we actively move control our sensors perceive world. Whether active sensing coupled with cycle remains largely unknown. Here, recorded electrocardiograms human participants while they performed a tactile grating orientation task. We show that duration subjects’ touch varied as function initiated it. Touches systole were held for longer periods time than touches diastole phase. effect was most pronounced when elongating sense difficult gratings. Conversely, condition cycle, their length did vary these initiated. Our results reveal spend more during periods, associated lower perceptual sensitivity (vs. diastole). In line interoceptive inference accounts, indicate adjust acquisition data internal bodily cycles.

Language: Английский

---

Circuit formation and sensory perception in the mouse olfactory system

Frontiers in Neural Circuits, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 16, 2024

In the mouse olfactory system, odor information is converted to a topographic map of activated glomeruli in bulb (OB). Although arrangement genetically determined, glomerular structure plastic and can be modified by environmental stimuli. If pups are exposed particular odorant, responding become larger recruiting dendrites connecting projection neurons interneurons. This imprinting not only increases sensitivity odor, but also imposes positive quality on imprinted memory. External represented as an OB transmitted cortex (OC) amygdala for decision making elicit emotional behavioral outputs using two distinct neural pathways, innate learned. Innate circuits start work right after birth, whereas learned functional later on. this paper, recent progress will summarized study circuit formation perception mice. We propose new hypotheses timing gating activity relation respiration cycle.

Language: Английский

---

Twitches, Blinks, and Fidgets: Important Generators of Ongoing Neural Activity

The Neuroscientist, Journal Year: 2018, Volume and Issue: 25(4), P. 298 - 313

Published: Oct. 12, 2018

Animals and humans continuously engage in small, spontaneous motor actions, such as blinking, whisking, postural adjustments (“fidgeting”). These movements are accompanied by changes neural activity sensory regions of the brain. The frequency these motions varies time, is affected stimuli, arousal levels, pathology. fidgeting behaviors can be entrained stimuli. Fidgeting will cause distributed, bilateral functional activation 0.01 to 0.1 Hz range that show up magnetic resonance imaging wide-field calcium neuroimaging studies, contribute observed connectivity among brain regions. However, despite large potential drive brain-wide activity, fidget-like rarely monitored. We argue studies evoked dynamics awake animals should closely monitor behaviors. Differences due or pathology “contaminate” ongoing lead apparent differences connectivity. Monitoring accounting for activations essential during experiments differentiate fidget-driven from internally driven dynamics.

Language: Английский

---