Understanding the retinal basis of vision across species

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 21(1), P. 5 - 20

Published: Nov. 28, 2019

Language: Английский

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Fovea-like Photoreceptor Specializations Underlie Single UV Cone Driven Prey-Capture Behavior in Zebrafish

Neuron, Journal Year: 2020, Volume and Issue: 107(2), P. 320 - 337.e6

Published: May 29, 2020

In the eye, function of same-type photoreceptors must be regionally adjusted to process a highly asymmetrical natural visual world. Here, we show that UV cones in larval zebrafish area temporalis are specifically tuned for UV-bright prey capture their upper frontal field, which may use signal from single cone at time. For this, UV-photon detection probability is boosted more than 10-fold. Next, vivo two-photon imaging, transcriptomics, and computational modeling reveal these an elevated baseline synaptic calcium facilitate encoding bright objects, turn results expressional tuning phototransduction genes. Moreover, light-driven slowed by interactions with horizontal cells later accentuated level glutamate release driving retinal networks. These regional differences tally variations between peripheral foveal primates hint common mechanistic origin.

Language: Английский

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Ancestral photoreceptor diversity as the basis of visual behaviour

Nature Ecology & Evolution, Journal Year: 2024, Volume and Issue: 8(3), P. 374 - 386

Published: Jan. 22, 2024

Language: Английский

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Deconstructing Hunting Behavior Reveals a Tightly Coupled Stimulus-Response Loop

Current Biology, Journal Year: 2019, Volume and Issue: 30(1), P. 54 - 69.e9

Published: Dec. 19, 2019

Language: Английский

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The Retinal Basis of Vertebrate Color Vision

Annual Review of Vision Science, Journal Year: 2019, Volume and Issue: 5(1), P. 177 - 200

Published: June 21, 2019

The jawless fish that were ancestral to all living vertebrates had four spectral cone types probably served by chromatic-opponent retinal circuits. Subsequent evolution of photoreceptor sensitivities is documented for many vertebrate lineages, giving insight into the ecological adaptation color vision. Beyond photoreceptors, processing best understood in mammals, especially blue

Language: Английский

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True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field

eLife, Journal Year: 2020, Volume and Issue: 9

Published: May 28, 2020

Color, an important visual cue for survival, is encoded by comparing signals from photoreceptors with different spectral sensitivities. The mouse retina expresses a short wavelength-sensitive and middle/long opsin (S- M-opsin), forming opposing, overlapping gradients along the dorsal-ventral axis. Here, we analyzed distribution of all cone types across entire two commonly used strains. We found, unexpectedly, that ‘true S-cones’ (S-opsin only) are highly concentrated (up to 30% cones) in ventral retina. Moreover, S-cone bipolar cells (SCBCs) also skewed towards retina, wiring patterns matching true S-cones. In addition, S-cones form clusters, which may augment synaptic input SCBCs. Such unique SCBC connecting pattern forms basis color vision, likely reflecting evolutionary adaptation enhance coding upper field suitable mice’s habitat behavior.

Language: Английский

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Seeing the rainbow: mechanisms underlying spectral sensitivity in teleost fishes

Journal of Experimental Biology, Journal Year: 2020, Volume and Issue: 223(8)

Published: April 15, 2020

ABSTRACT Among vertebrates, teleost eye diversity exceeds that found in all other groups. Their spectral sensitivities range from ultraviolet to red, and the number of visual pigments varies 1 over 40. This variation is correlated with different ecologies life histories fish species, including their variable aquatic habitats: murky lakes, clear oceans, deep seas turbulent rivers. These ecotopes often change season, but may also migrate between diurnally, seasonally or ontogenetically. To survive these light habitats, systems have evolved a suite mechanisms modulate on timescales. include: (1) optical media filter light, (2) variations photoreceptor type size vary absorbance sensitivity, (3) changes optimize peak sensitivity. The pigment can result chromophore opsin. Opsin results opsin sequence, expression co-expression, gene duplications losses. Here, we review groups where structural molecular underlying been relatively well determined. Although document considerable variability, this alone does not imply functional difference per se. We therefore highlight need for more studies examine species known sensitivity differences, emphasizing behavioral experiments test whether such differences actually matter execution tasks are relevant fish.

Language: Английский

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The Zebrafish Visual System: From Circuits to Behavior

Annual Review of Vision Science, Journal Year: 2019, Volume and Issue: 5(1), P. 269 - 293

Published: Sept. 15, 2019

Visual stimuli can evoke complex behavioral responses, but the underlying streams of neural activity in mammalian brains are difficult to follow because their size. Here, I review visual system zebrafish larvae, highlighting where recent experimental evidence has localized functional steps visuomotor transformations specific brain areas. The retina a larva encodes behaviorally relevant information distributed across feature-selective ganglion cells such that signals representing distinct stimulus properties arrive different areas or layers brain. Motor centers hindbrain encode motor variables precisely tuned needs within given setting. Owing rapid technological progress, larval provide unique opportunities for obtaining comprehensive understanding intermediate processing occurring between and centers, revealing how implemented vertebrate

Language: Английский

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Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior

Neuron, Journal Year: 2020, Volume and Issue: 109(4), P. 645 - 662.e9

Published: Dec. 23, 2020

Language: Английский

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An arbitrary-spectrum spatial visual stimulator for vision research

eLife, Journal Year: 2019, Volume and Issue: 8

Published: Sept. 23, 2019

Visual neuroscientists require accurate control of visual stimulation. However, few stimulator solutions simultaneously offer high spatio-temporal resolution and free over the spectra light sources, because they rely on off-the-shelf technology developed for human trichromatic vision. Importantly, consumer displays fail to drive UV-shifted short wavelength-sensitive photoreceptors, which strongly contribute behaviour in many animals, including mice, zebrafish fruit flies. Moreover, non-mammalian species feature more than three spectral photoreceptor types. Here, we present a flexible, spatial with up six arbitrary spectrum chromatic channels. It combines standard digital processing engine open source hard- software that can be easily adapted experimentalist’s needs. We demonstrate capability this general experimentally vitro mouse retinal whole-mount vivo zebrafish. With work, intend start community effort sharing developing common design vision research.

Language: Английский

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