Locus coeruleus noradrenergic neurons phase-lock to prefrontal and hippocampal infra-slow rhythms that synchronize to behavioral events DOI Creative Commons

Liyang Xiang,

Antoine Harel, Ralitsa Todorova

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 21, 2023

The locus coeruleus (LC) is the primary source of noradrenergic projections to forebrain, and, in prefrontal cortex, implicated decision-making and executive function. LC neurons phase-lock cortical infra-slow wave oscillations during sleep. Such rhythms are rarely reported awake states, despite their interest, since they correspond time scale behavior. Thus, we investigated neuronal synchrony with rats performing an attentional set-shifting task. Local field potential (LFP) oscillation cycles cortex hippocampus on order 0.4 Hz phase-locked task events at crucial maze locations. Indeed, successive showed different wavelengths, as if periodic that can reset phase relative salient events. Simultaneously recorded could show cycle durations well, suggesting independent control. Most (including optogenetically identified neurons) here were these rhythms, hippocampal units LFP probes. also phase-modulated gamma amplitude, linking behavior those coordinating synchrony. This would provide a mechanism where noradrenaline, released by concert rhythm, facilitate synchronization or brain networks, underlying behavioral adaptation.

Language: Английский

Hippocampo-cortical circuits for selective memory encoding, routing, and replay DOI
Ryan E. Harvey, Heath L. Robinson, Can Liu

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(13), P. 2076 - 2090.e9

Published: May 16, 2023

Language: Английский

Citations

65
Associative and predictive hippocampal codes support memory-guided behaviors DOI
Can Liu, Ralitsa Todorova, Wenbo Tang

et al.

Science, Journal Year: 2023, Volume and Issue: 382(6668)

Published: Oct. 19, 2023

Episodic memory involves learning and recalling associations between items their spatiotemporal context. Those memories can be further used to generate internal models of the world that enable predictions made. The mechanisms support these associative predictive aspects are not yet understood. In this study, we an optogenetic manipulation perturb sequential structure, but global network dynamics, place cells as rats traversed specific spatial trajectories. This perturbation abolished replay those trajectories development representations, leading impaired new optimal during memory-guided navigation. However, cell assembly reactivation reward-context were unaffected. Our results show a mechanistic dissociation two complementary hippocampal codes: code (through coactivity) sequences).

Language: Английский

Citations

56
Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective DOI Creative Commons
Ileana L. Hanganu‐Opatz, Thomas Klausberger, Torfi Sigurdsson

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1020 - 1036

Published: April 1, 2023

Language: Английский

Citations

51
Neuronal ensembles: Building blocks of neural circuits DOI Creative Commons
Rafael Yuste, Rosa Cossart, Emre Yaksi

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(6), P. 875 - 892

Published: Jan. 22, 2024

Language: Английский

Citations

36
Cell type diversity in a developing octopus brain DOI Creative Commons
Ruth Styfhals, Grygoriy Zolotarov, Gert Hulselmans

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 30, 2022

Abstract Octopuses are mollusks that have evolved intricate neural systems comparable with vertebrates in terms of cell number, complexity and size. The brain types control their sophisticated behavioral repertoire still unknown. Here, we profile the diversity paralarval Octopus vulgaris to build a type atlas comprises mostly cells, but also multiple glial subtypes, endothelial cells fibroblasts. We spatially map vertical, subesophageal optic lobes. Investigation conservation reveals shared gene signature between mouse, fly octopus. Genes related learning memory enriched vertical lobe which show molecular similarities Kenyon Drosophila . construct taxonomy revealing transcriptionally types, tend appear same region. Together, our data sheds light on evolution octopus brain.

Language: Английский

Citations

48
Amygdalo-cortical dialogue underlies memory enhancement by emotional association DOI Creative Commons
Yoshihito Saito, Yuma Osako, Maya Odagawa

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Interictal epileptiform discharges affect memory in an Alzheimer’s disease mouse model DOI Creative Commons
Marisol Soula, Anna Maslarova, Ryan E. Harvey

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(34)

Published: Aug. 17, 2023

Interictal epileptiform discharges (IEDs) are transient abnormal electrophysiological events commonly observed in epilepsy patients but also present other neurological diseases, such as Alzheimer's disease (AD). Understanding the role IEDs have on hippocampal circuit is important for our understanding of cognitive deficits seen and AD. We characterize compare human from microwire recording with those AD transgenic mice implanted multilayer silicon probes. Both local field potential features firing patterns pyramidal cells interneurons were similar mouse human. found that emerged CA3-1 circuits, they recruited silenced interneurons, followed by post-IED suppression. suppressed incidence altered properties physiological sharp-wave ripples, their properties, interfered replay place sequences a maze. In addition, inversely correlated daily memory performance. Together, work implies may common epilepsy-independent phenomenon neurodegenerative diseases perturbs hippocampal-cortical communication interferes memory.

Language: Английский

Citations

14
Striatum expresses region-specific plasticity consistent with distinct memory abilities DOI Creative Commons

Sylvie Pérez,

Yihui Cui, Gaëtan Vignoud

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 38(11), P. 110521 - 110521

Published: March 1, 2022

Language: Английский

Citations

20
Synchronous processing of temporal information across the hippocampus, striatum, and orbitofrontal cortex DOI Open Access
Akihiro Shimbo,

Y. Sekine,

Saori Kashiwagi

et al.

Published: Jan. 31, 2025

Information processing for interval timing is supported by several brain regions, including the hippocampus, basal ganglia, and frontal cortical areas. However, little known about mechanism which temporal information processed cooperatively in distributed network. Here, we investigated neuronal of hippocampal CA1, dorsal striatum, orbitofrontal cortex simultaneously recording activity during a bisection task. We found time cells representing elapsed period across all three regions. Seeking potential correlative representation time, that theta oscillations were dominant these areas modulated cells. Moreover, synchronization cell pairs was also regulated oscillations. Taken together, results demonstrated presence synchronous on fine scale, In addition, decoding analysis revealed correlated with rats’ decisions based their internal estimation, decoded showing correlations Thus, cooperative time-cell assemblies regions reflected recognition rats. conclusion, demonstrate pivotal role supporting

Language: Английский

Citations

0
Synchronous processing of temporal information across the hippocampus, striatum, and orbitofrontal cortex DOI Open Access
Akihiro Shimbo,

Y. Sekine,

Saori Kashiwagi

et al.

Published: Jan. 31, 2025

Information processing for interval timing is supported by several brain regions, including the hippocampus, basal ganglia, and frontal cortical areas. However, little known about mechanism which temporal information processed cooperatively in distributed network. Here, we investigated neuronal of hippocampal CA1, dorsal striatum, orbitofrontal cortex simultaneously recording activity during a bisection task. We found time cells representing elapsed period across all three regions. Seeking potential correlative representation time, that theta oscillations were dominant these areas modulated cells. Moreover, synchronization cell pairs was also regulated oscillations. Taken together, results demonstrated presence synchronous on fine scale, In addition, decoding analysis revealed correlated with rats’ decisions based their internal estimation, decoded showing correlations Thus, cooperative time-cell assemblies regions reflected recognition rats. conclusion, demonstrate pivotal role supporting

Language: Английский

Citations

0