Biosensors,
Journal Year:
2025,
Volume and Issue:
15(5), P. 280 - 280
Published: April 29, 2025
Parkinson’s
disease
(PD),
a
neurodegenerative
disorder
marked
by
the
progressive
loss
of
dopaminergic
neurons
in
substantia
nigra,
imposes
substantial
economic
burdens,
including
both
direct
and
indirect
costs.
The
medical
community
currently
lacks
definitive
cure
for
disease,
early
detection
is
crucial
timely
intervention
management.
As
innovative
diagnostic
tools,
biosensors
have
shown
great
potential
detecting
PD
at
its
stages.
This
review
comprehensively
summarizes
recent
advances
PD,
with
particular
focus
on
two
key
biomarkers:
dopamine
(DA)
α-synuclein
(α-syn).
Furthermore,
it
illustrates
variety
nanotechnology-based
biosensors,
optical,
electrochemical,
transistor
detailing
their
underlying
principles,
advantages,
limitations,
applications
detection.
Moreover,
explores
challenges
prospects
advancing
diagnosis.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Dec. 6, 2023
Gut-liver-brain
axis
is
a
three-way
highway
of
information
interaction
system
among
the
gastrointestinal
tract,
liver,
and
nervous
systems.
In
past
few
decades,
breakthrough
progress
has
been
made
in
gut
liver
brain
axis,
mainly
through
understanding
its
formation
mechanism
increasing
treatment
strategies.
this
review,
we
discuss
various
complex
networks
including
barrier
permeability,
hormones,
microbial
metabolites,
vagus
nerve,
neurotransmitters,
immunity,
toxic
β-amyloid
(Aβ)
metabolism,
epigenetic
regulation
gut-liver-brain
axis.
Some
therapies
containing
antibiotics,
probiotics,
prebiotics,
synbiotics,
fecal
microbiota
transplantation
(FMT),
polyphenols,
low
FODMAP
diet
nanotechnology
application
regulate
Besides,
some
special
treatments
targeting
gut-liver
include
farnesoid
X
receptor
(FXR)
agonists,
takeda
G
protein-coupled
5
(TGR5)
glucagon-like
peptide-1
(GLP-1)
antagonists
fibroblast
growth
factor
19
(FGF19)
analogs.
Targeting
gut-brain
embraces
cognitive
behavioral
therapy
(CBT),
antidepressants
tryptophan
metabolism-related
therapies.
liver-brain
contains
Aβ
future,
better
interactions
will
promote
development
novel
preventative
strategies
discovery
precise
therapeutic
targets
multiple
diseases.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 23, 2024
Ferroptosis
is
a
non-apoptotic
mode
of
programmed
cell
death
characterized
by
iron
dependence
and
lipid
peroxidation.
Since
the
ferroptosis
was
proposed,
researchers
have
revealed
mechanisms
its
formation
continue
to
explore
effective
inhibitors
in
disease.
Recent
studies
shown
correlation
between
pathological
neurodegenerative
diseases,
as
well
diseases
involving
tissue
or
organ
damage.
Acting
on
ferroptosis-related
targets
may
provide
new
strategies
for
treatment
ferroptosis-mediated
diseases.
This
article
specifically
describes
metabolic
pathways
summarizes
reported
action
natural
synthetic
small
molecule
their
efficacy
The
paper
also
treatments
such
gene
therapy,
nanotechnology,
summarises
challenges
encountered
clinical
translation
inhibitors.
Finally,
relationship
other
modes
discussed,
hopefully
paving
way
future
drug
design
discovery.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5293 - 5293
Published: May 13, 2024
Dopamine
is
a
key
neurotransmitter
involved
in
physiological
processes
such
as
motor
control,
motivation,
reward,
cognitive
function,
and
maternal
reproductive
behaviors.
Therefore,
dysfunctions
of
the
dopaminergic
system
are
related
to
plethora
human
diseases.
Dopamine,
via
different
circuitries
implicated
compulsive
behavior,
habit
formation,
also
represents
player
substance
use
disorder
formation
perpetuation
mechanisms
leading
addiction.
Here,
we
propose
dopamine
model
not
only
neurotransmission
but
neuromodulation
capable
modifying
neuronal
architecture.
Abuse
substances
like
methamphetamine,
cocaine,
alcohol
their
consumption
over
time
can
induce
changes
activities.
These
modifications
lead
synaptic
plasticity
finally
morphological
functional
changes,
starting
from
maladaptive
neuro-modulation
ending
neurodegeneration.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(2), P. 369 - 369
Published: Jan. 17, 2025
This
paper
summarizes
the
main
findings
of
a
study
which
aimed
to
examine
electrochemical
oxidation
homovanillic
acid
(HVA),
final
metabolite
dopamine.
A
pencil
graphite
electrode
(PGE)
was
used
as
working
and
measurements
were
performed
by
cyclic
voltammetry
(CV)
differential
pulse
(DPV).
The
type
composition
leads
PGE,
pH
supporting
electrolyte,
well
scan
rates
optimized
CV.
analyte
irreversibly
oxidized
in
Britton-Robinson
buffer
(BRB)
solutions.
interpretation
voltammetric
signals
correlation
acquired
information
key
addressing
process
undergone
HVA
at
PGE.
outcomes
rate
studies
led
conclusion
that
two
electrons
protons
involved
diffusion-controlled
process.
Using
linear
relationship
between
peak
current
concentration
obtained
1.0
×
10-6
M
5.0
10-5
DPV
BRB
with
2.0.
detection
limit
3.84
10-7
calculated.
accuracy,
precision,
selectivity
quantitative
method
have
successfully
evaluation.
practical
application
developed
checked
determining
spiked
plasma
samples,
yielding
good
recovery
values.
Gels,
Journal Year:
2022,
Volume and Issue:
9(1), P. 2 - 2
Published: Dec. 22, 2022
Currently,
uncontrolled
bleeding
remains
a
serious
problem
in
emergency,
surgical
and
battlefield
environments.
Despite
the
specific
properties
of
available
hemostatic
agents,
sealants,
adhesives,
effective
hemostasis
under
wet
dynamic
conditions
challenge.
In
recent
years,
polymeric
hydrogels
with
excellent
have
received
much
attention
because
their
adjustable
mechanical
properties,
high
porosity,
biocompatibility.
this
review,
to
investigate
role
hemostasis,
mechanisms
hydrogel
adhesion
are
firstly
elucidated,
design
strategies
environments
briefly
introduced,
then,
based
on
comprehensive
literature
studies
vivo
applications
wet-adhesive
different
summarized,
improvement
directions
such
future
proposed.
Environment & Health,
Journal Year:
2024,
Volume and Issue:
2(7), P. 424 - 440
Published: May 4, 2024
Triclosan
(TCS)
has
garnered
significant
attention
due
to
its
widespread
use
and
associated
endocrine-disrupting
effects.
However,
impact
on
the
neuroendocrine
system
underlying
mechanisms
remain
poorly
understood.
Here,
we
established
correlations
between
TCS
exposure
serum
sex
hormone
levels
in
participants
of
National
Health
Nutrition
Examination
Survey
(NHANES).
Additionally,
investigated
TCS's
influence
using
adult
zebrafish
exposed
environmentally
relevant
concentrations
(0.361–48.2
μg/L)
for
21
days.
Assessment
reproductive
neurotoxicity
included
histopathological
examination
behavioral
tests.
Transcriptomics,
proteomics
analyses,
biochemical
detection
were
employed
elucidate
TCS-induced
disruption.
Significant
found
estradiol,
testosterone,
hormone-binding
globulin
NHANES
participants.
In
addition,
inhibited
ovary
development
spermatogenesis
zebrafish.
Transcriptomics
analysis
revealed
gender-specific
key
signaling
metabolism-related
pathways
implicated
toxicity.
Moreover,
induced
nervous
impairment,
as
evidenced
by
histological
changes
altered
motor
behavior,
possibly
with
oxidative
damage.
Correlation
further
highlighted
potential
connection
endocrine
disruption
impairment
following
exposure.
Overall,
this
study
provided
evidence
supporting
offered
insights
into
mechanisms.
