Current Opinion in Physiology, Journal Year: 2020, Volume and Issue: 19, P. 10 - 16
Published: June 30, 2020
Language: Английский
Trends in Cell Biology, Journal Year: 2020, Volume and Issue: 30(10), P. 805 - 817
Published: Sept. 2, 2020
Language: Английский
Citations
491
Fluids and Barriers of the CNS, Journal Year: 2023, Volume and Issue: 20(1)
Published: March 28, 2023
Abstract The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and forms tight junctions which limit the passive diffusions of ions solutes. blood–brain barrier (BBB), composed brain microvascular associated pericytes end-feet astrocytes, a physical biological to maintain microenvironment. expression CLDN-5 tightly regulated BBB by other junctional proteins supports from astrocytes. most recent literature clearly shows compromised with decline increasing risks developing neuropsychiatric disorders, epilepsy, calcification dementia. purpose this review summarize known diseases function. In first part review, we highlight understanding how as well astrocytes cells. We detail some drugs can enhance these are being developed or currently use treat decline. then summarise mutagenesis-based studies have facilitated better physiological role protein at demonstrated functional consequences recently identified pathogenic missense mutation patients alternating hemiplegia childhood. This gain-of-function CLDN family all others representing loss-of-function mutations resulting mis-localization and/or attenuated Finally, reports about dosage-dependent effect on development neurological mice discuss what cellular for regulation human diseases.
Language: Английский
Citations
65
Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(4), P. 290 - 308
Published: Jan. 3, 2024
Language: Английский
Citations
50
Biophysical Reviews, Journal Year: 2019, Volume and Issue: 11(5), P. 783 - 793
Published: Oct. 1, 2019
Language: Английский
Citations
136
Science, Journal Year: 2020, Volume and Issue: 370(6520)
Published: Nov. 27, 2020
Tension where multiple cells meet Cells exist in varying environments and must respond to specific stimuli. During development, epithelial need rapidly reorganize under tension without compromising integrity. Yu et al. demonstrate that Drosophila achieve this by transiently stabilizing adhesion at tricellular junctions three (see the Perspective Raghavan Vasioukhin). The conserved regulator Canoe/Afadin is recruited within seconds dissociates when released through a mechanism requires Abl-dependent tyrosine phosphorylation. These results identify an vivo mechanotransduction pathway dynamically couples with physiological forces, allowing modulate their behavior response mechanical changes environment. Science , issue p. eaba5528 ; see also 1036
Language: Английский
Citations
93
Biochimica et Biophysica Acta (BBA) - Biomembranes, Journal Year: 2020, Volume and Issue: 1862(9), P. 183339 - 183339
Published: May 7, 2020
Language: Английский
Citations
81
The Journal of Cell Biology, Journal Year: 2022, Volume and Issue: 221(4)
Published: March 7, 2022
Epithelial cell–cell junctions remodel in response to mechanical stimuli maintain barrier function. Previously, we found that local leaks tight (TJs) are rapidly repaired by local, transient RhoA activation, termed “Rho flares,” but how Rho flares regulated is unknown. Here, discovered intracellular calcium flashes and junction elongation early events the flare pathway. Both laser-induced naturally occurring TJ breaks lead at site of leaks. Additionally, induced optogenetics increases frequency, suggesting mechanically triggered. Depletion or inhibition mechanosensitive channels (MSCs) reduces amplitude diminishes sustained activation flares. MSC-dependent influx necessary global function regulating reinforcement proteins via contraction. In all, uncovered a novel role for remodeling, allowing epithelial cells repair stimuli.
Language: Английский
Citations
57
Cells, Journal Year: 2023, Volume and Issue: 12(23), P. 2701 - 2701
Published: Nov. 24, 2023
Tight junctions (TJ) are cell–cell adhesive structures that define the permeability of barrier-forming epithelia and endothelia. In contrast to this seemingly static function, TJs display a surprisingly high molecular complexity unexpected dynamic regulation, which allows maintain barrier in presence physiological forces response perturbations. Cell–cell adhesion receptors play key roles during regulation TJs. They connect individual cells within cellular sheets link sites contacts underlying actin cytoskeleton. Recent findings support transmitting mechanical promoting phase separation. review, we discuss newly discovered functions cell localized at their role function.
Language: Английский
Citations
26
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114905 - 114905
Published: June 3, 2023
Language: Английский
Citations
23
The Journal of Cell Biology, Journal Year: 2024, Volume and Issue: 223(5)
Published: March 22, 2024
Epithelia must be able to resist mechanical force preserve tissue integrity. While intercellular junctions are known important for the resistance of epithelia, roles tight (TJs) remain established. We previously demonstrated that epithelial cells devoid TJ membrane proteins claudins and JAM-A completely lack TJs exhibit focal breakages their apical junctions. Here, we demonstrate fracture when claudin/JAM-A–deficient undergo spontaneous cell stretching. The junction was accompanied by actin disorganization, polymerization required integrity in cells. Further deletion CAR resulted disruption ZO-1 molecule ordering at junctions, severe defects These results regulate junctional complex
Language: Английский
Citations
12