Emergence of large-scale cell death through ferroptotic trigger waves

Nature, Journal Year: 2024, Volume and Issue: 631(8021), P. 654 - 662

Published: July 10, 2024

Abstract Large-scale cell death is commonly observed during organismal development and in human pathologies 1–5 . These events extend over great distances to eliminate large populations of cells, raising the question how can be coordinated space time. One mechanism that enables long-range signal transmission trigger waves 6 , but this might used for remains unclear. Here we demonstrate ferroptosis, an iron- lipid-peroxidation-dependent form death, propagate across cells long (≥5 mm) at constant speeds (around 5.5 μm min −1 ) through reactive oxygen species (ROS). Chemical genetic perturbations indicate a primary role ROS feedback loops (Fenton reaction, NADPH oxidase signalling glutathione synthesis) controlling progression ferroptotic waves. We show introducing stress suppression cystine uptake activates these loops, converting cellular redox systems from being monostable bistable thereby priming become media which propagate. Furthermore, ferroptosis its propagation accompany massive, yet spatially restricted, muscle remodelling embryonic avian limb, substantiating use as tissue-sculpting strategy embryogenesis. Our findings highlight coordinating global events, providing paradigm investigating large-scale pathologies.

Language: Английский

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A naphthalimido-based fluorescent probe for HOCl sensing with excellent lysosome-targeted performance

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141393 - 141393

Published: Jan. 1, 2025

Language: Английский

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Ratiometric Fluorescent Probe for Super-Resolution Imaging of Lysosome HClO in Ferroptosis Cells

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Ferroptosis is an iron-dependent programmed cell death that characterized by the dysregulation of lipid reactive oxygen species (ROS) production, causing abnormal changes in hypochlorous acid (HClO) levels lysosomes. Super-resolution imaging can observe fine structure lysosome at nanometer level; therefore, it be used to detect HClO during ferroptosis suborganelle level. Herein, we utilize a ratiometric fluorescent probe,

Language: Английский

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Ferroptosis at the nexus of metabolism and metabolic diseases

Theranostics, Journal Year: 2024, Volume and Issue: 14(15), P. 5826 - 5852

Published: Jan. 1, 2024

Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a crucial regulator human physiology and pathology. Increasing evidence showcases reciprocal relationship between ferroptosis dysregulated metabolism, propagating pathogenic vicious cycle that exacerbates pathology diseases, particularly metabolic disorders. Consequently, there rapidly growing interest in developing ferroptosis-based therapeutics. Therefore, comprehensive understanding the intricate interplay metabolism could provide invaluable resource for mechanistic insight therapeutic development. In this review, we summarize important substances associated pathways initiation progression, outline cascade responses disease development, overview roles mechanisms introduce methods detection, discuss perspectives ferroptosis, which collectively aim to illustrate view basic, translational, clinical science.

Language: Английский

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Lipid droplet-targeting fluorescent probes for monitoring hydrogen sulfide in ferroptosis

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 344156 - 344156

Published: May 1, 2025

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Aggregation‐based dual‐target probe for dual‐colour super‐resolution monitoring mitophagy and evaluating drugs regulating mitochondria

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Developing single fluorescent probe for simultaneously visualizing mitophagy flux and oxidative stress with super‐resolution is highly demanded yet quite challenging. Herein, a ratiometric HClO AHOH designed synthesized which capable of staining lysosomes mitochondria red green colour, respectively. could be selectivity oxidized by HClO, leading to large emission blue shift (90 nm) an over 1300‐fold enhancement the ratio Fl 547nm / 637nm . We apply in microscopy clearly visualize dynamics mitochondria–lysosomes interactions states upon different stimuli. Mitochondria dysfunction triggered drugs genetic defect lead elevated higher levels mitophagy. Moreover, serve as reliable tool evaluating efficacy regulating dysfunction. This work provides powerful dual‐colour imaging agent real‐time monitoring organelle stress.

Language: Английский

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Ferroptosis in hepatocellular carcinoma: Mechanisms and therapeutic implications

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 182, P. 117769 - 117769

Published: Dec. 16, 2024

Language: Английский

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Advances in ferroptosis: Synergistic therapies and fluorescent probes as arrows to target cancer's achilles heel

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 541, P. 216779 - 216779

Published: May 24, 2025

Language: Английский

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Research progress on ferroptosis in colorectal cancer

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 18, 2024

Ferroptosis is a new form of cell death that differs from traditional forms death. It ferroptosis-dependent lipid peroxidation Colorectal cancer(CRC) the most common tumor in gastrointestinal tract with long occultation period and poor five-year prognosis. Exploring effective systemic treatments for CRC remains great challenge worldwide. Numerous studies have demonstrated ferroptosis can participate biological malignant process various tumor, including CRC, so understanding role regulatory mechanisms plays crucial treatment CRC. In this paper, we reviews associated factors their interactions immune cells microenvironment. addition, targeting has emerged as an encouraging strategy treatment. Finally, to inform subsequent research clinical diagnosis treatment, review therapeutic approaches radiotherapy, immunotherapy, herbal therapy ferroptosis.

Language: Английский

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Recent advances in single fluorescent probes for monitoring dual organelles in two channels

Smart Molecules, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Organelles are specialized areas where cells perform specific processes necessary for life and actively communicate with each other to keep the whole cell functioning. Disorders of organelle networks associated multiple pathological processes. However, clearly intuitively visualizing highly dynamic interactions between ultrafine organelles is challenging. Fluorescence imaging technology provides opportunities due distinct advantages facile, non‐invasiveness detection, making it particularly well‐suited applications in uncovering mysterious veil interactions. Regrettably, lack ideal fluorescence agents has always been an obstacle intricate behaviors organelles. In this review, we provide a systematic discussion on existing dual‐color dual‐targetable molecular sensors used monitoring interactions, focus their targeting strategies, mechanisms biological applications. Additionally, current limitations future development directions probes dual‐emissives briefly discussed. This review aims guidance researchers develop more improved studying biomedical field.

Language: Английский

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