Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
252, P. 114630 - 114630
Published: Feb. 8, 2023
Rotenone,
a
widely
used
pesticide,
causes
dopaminergic
neurons
loss
and
increase
the
risk
of
Parkinson's
disease
(PD).
However,
few
studies
link
role
PARP1
to
neuroinflammatory
response
autophagy
dysfunction
in
rotenone-induced
neurodegeneration.
Here,
we
identified
that
overactivation
caused
by
rotenone
led
NLRP3-mediated
inflammation.
Further
results
showed
inhibition
could
reduce
inflammation,
which
was
effectively
eliminated
TFEB
knockdown.
Moreover,
poly(ADP-ribosyl)ated
reduced
autophagy.
Of
note,
rescue
loss.
Overall,
our
study
revealed
blocks
through
poly
(ADP-ribosyl)ating
inhibited
NLRP3
degradation,
suggests
intervention
PARP1-TFEB-NLRP3
signaling
can
be
new
treatment
strategy
for
Communications Biology,
Journal Year:
2021,
Volume and Issue:
4(1)
Published: Nov. 3, 2021
Abstract
Poly(ADP-ribosyl)ation
catalyzed
by
poly(ADP-ribose)
polymerases
(PARPs)
is
one
of
the
immediate
cellular
responses
to
DNA
damage.
The
histone
PARylation
factor
1
(HPF1)
discovered
recently
form
a
joint
active
site
with
PARP1
and
PARP2
was
shown
limit
activity
PARPs
stimulate
their
NAD
+
-hydrolase
activity.
Here
we
demonstrate
that
HPF1
can
DNA-dependent
DNA-independent
autoPARylation
as
well
heteroPARylation
histones
in
complex
nucleosome.
stimulatory
action
detected
defined
range
concentrations
at
which
no
HPF1-dependent
enhancement
hydrolytic
consumption
occurs.
PARP2,
comparing
PARP1,
more
efficiently
stimulated
reaction
than
automodification,
suggesting
specific
role
ADP-ribosylation-dependent
modulation
chromatin
structure.
Possible
dual
function
maintaining
PARP
discussed.
Regenerative Therapy,
Journal Year:
2024,
Volume and Issue:
25, P. 320 - 330
Published: Feb. 2, 2024
It
is
essential
to
acknowledge
that
the
cardiovascular
toxicity
associated
with
anthracycline
drugs
can
be
partially
attributed
damage
inflicted
on
blood
vessels
and
endothelial
cells.
Extracellular
vesicles
(EVs)
derived
from
mesenchymal
stem
cells
(MSCs)
have
potential
repair
cellular
processes
promote
tissue
regeneration
through
transfer
of
signaling
molecules
such
as
miRNAs.
In
present
study,
we
investigated
effects
MSC-EVs
daunorubicin
(DNR)-damaged
human
cardiac
microvascular
(HCMEC)
developing
Chicken
Chorioallantoic
Membrane
(CAM)
in
vivo.
Neuroscience Bulletin,
Journal Year:
2023,
Volume and Issue:
40(2), P. 218 - 240
Published: May 31, 2023
Abstract
As
the
aging
population
continues
to
grow
rapidly,
age-related
diseases
are
becoming
an
increasing
burden
on
healthcare
system
and
a
major
concern
for
well-being
of
elderly
individuals.
While
is
inevitable
process
all
humans,
it
can
be
slowed
down
treated
or
alleviated.
Nicotinamide
adenine
dinucleotide
(NAD)
critical
coenzyme
cofactor
that
plays
central
role
in
metabolism
involved
various
cellular
processes
including
maintenance
metabolic
homeostasis,
post-translational
protein
modifications,
DNA
repair,
immune
responses.
individuals
age,
their
NAD
levels
decline,
this
decrease
has
been
suggested
contributing
factor
development
numerous
diseases,
such
as
cancer,
diabetes,
cardiovascular
neurodegenerative
diseases.
In
pursuit
healthy
aging,
researchers
have
investigated
approaches
boost
maintain
levels.
Here,
we
provide
overview
summarize
recent
progress
strategies
target
treatment
particularly
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
252, P. 114630 - 114630
Published: Feb. 8, 2023
Rotenone,
a
widely
used
pesticide,
causes
dopaminergic
neurons
loss
and
increase
the
risk
of
Parkinson's
disease
(PD).
However,
few
studies
link
role
PARP1
to
neuroinflammatory
response
autophagy
dysfunction
in
rotenone-induced
neurodegeneration.
Here,
we
identified
that
overactivation
caused
by
rotenone
led
NLRP3-mediated
inflammation.
Further
results
showed
inhibition
could
reduce
inflammation,
which
was
effectively
eliminated
TFEB
knockdown.
Moreover,
poly(ADP-ribosyl)ated
reduced
autophagy.
Of
note,
rescue
loss.
Overall,
our
study
revealed
blocks
through
poly
(ADP-ribosyl)ating
inhibited
NLRP3
degradation,
suggests
intervention
PARP1-TFEB-NLRP3
signaling
can
be
new
treatment
strategy
for
