Plasma-activated saline hyperthermic perfusion-induced pyroptosis boosts peritoneal carcinomatosis immunotherapy

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

---

Immunoliposomes as an emerging nanocarrier for breast cancer therapy

European Polymer Journal, Journal Year: 2022, Volume and Issue: 184, P. 111781 - 111781

Published: Dec. 19, 2022

Language: Английский

---

Recent Findings on Therapeutic Cancer Vaccines: An Updated Review

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 503 - 503

Published: April 21, 2024

Cancer remains one of the global leading causes death and various vaccines have been developed over years against it, including cell-based, nucleic acid-based, viral-based cancer vaccines. Although many effective in vivo clinical studies some FDA-approved, there are major limitations to overcome: (1) developing universal vaccine for a specific is difficult, as tumors with different antigens individuals, (2) tumor may be similar body’s own antigens, (3) possibility recurrence. Therefore, personalized ability distinguish between indispensable. This paper provides comprehensive review types highlights important factors necessary efficient Moreover, application other technologies therapy discussed. Finally, several insights conclusions presented, such using cold plasma stem cells future vaccines, tackle developmental process.

Language: Английский

---

Lipid-based nanocarrier mediated CRISPR/Cas9 delivery for cancer therapy

Journal of Biomaterials Science Polymer Edition, Journal Year: 2022, Volume and Issue: 34(3), P. 398 - 418

Published: Sept. 9, 2022

CRISPR/Cas mediated gene-editing has opened new avenues for therapies that show great potential treating or curing cancers, genetic disorders, and microbial infections such as HIV. CRISPR/Cas9 tool is highly efficacious in revolutionizing the advent of genome editing; however, its efficient safe delivery a major hurdle due to cellular impermeability instability. Nano vectors could be explored scale up effective CRISPR/Cas9. This review highlights importance editing system cancer treatment along with effect lipid-based nanoparticles cells. The solid-lipid nanoparticles, nanostructured lipid carrier, niosomes have shown CRISPR compounds design application therapy been discussed future concern prospects nanoparticle based focused toward end.

Language: Английский

---

Galactose engineered nanocarriers: Hopes and hypes in cancer therapy

European Polymer Journal, Journal Year: 2022, Volume and Issue: 183, P. 111759 - 111759

Published: Dec. 10, 2022

Language: Английский

---

Effect of Plasma On-Time with a Fixed Duty Ratio on Reactive Species in Plasma-Treated Medium and Its Significance in Biological Applications

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5289 - 5289

Published: March 9, 2023

Optimizing the therapeutic range of nonthermal atmospheric pressure plasma (NTAPP) for biomedical applications is an active research topic. For first time, we examined effect on-times in this study while keeping duty ratio and treatment time fixed. We have evaluated electrical, optical, soft jet properties two different ratios 10% 36%, using 25, 50, 75, 100 ms. Furthermore, influence on-time on reactive oxygen nitrogen species (ROS/RNS) levels treated medium (PTM) was also investigated. Following treatment, characteristics (DMEM media) PTM (pH, EC, ORP) were examined. While EC ORP rose by raising on-time, pH remained unchanged. Finally, used to observe cell viability ATP U87-MG brain cancer cells. found it interesting that, increasing ROS/RNS dramatically increased significantly affected line. The results provide a significant indication advancement introducing optimization increase efficacy applications.

Language: Английский

---

Generation and measurement of low-temperature plasma for cancer therapy: a historical review

Free Radical Research, Journal Year: 2023, Volume and Issue: 57(3), P. 239 - 270

Published: March 4, 2023

This review provides a description of the historical background development biological applications low-temperature plasmas. The generation plasma, methods and devices, plasma sources, measurements properties, such as electron dynamics chemical species in both gaseous aqueous phases, were assessed. Currently, direct irradiation for discharges contacting surfaces, skin teeth, are related to interactions. Indirect using plasma-treated liquids based on plasma-liquid use these two is rapidly increasing preclinical studies cancer therapy. authors address prospects further developments therapeutic by understanding interactions between living organisms.

Language: Английский

---

Cold atmospheric plasma mediated cell membrane permeation and gene delivery-empirical interventions and pertinence

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 320, P. 102989 - 102989

Published: Aug. 29, 2023

Language: Английский

---

Violet phosphorene nanosheets and cold atmospheric plasma for synergetic cancer therapy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 475, P. 145884 - 145884

Published: Sept. 9, 2023

Language: Английский

---

Effects and Mechanisms of Non-Thermal Plasma-Mediated ROS and Its Applications in Animal Husbandry and Biomedicine

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15889 - 15889

Published: Nov. 2, 2023

Non-thermal plasma (NTP) is an ionized gas composed of neutral and charged reactive species, electric fields, ultraviolet radiation. NTP presents a relatively low discharge temperature because it characterized by the fact that values ions particles are much lower than electrons. Reactive species (atoms, radicals, ions, electrons) produced in delivered to biological objects induce set biochemical processes cells or tissues. can mediate oxygen (ROS) levels intensity- time-dependent manner. ROS homeostasis plays important role animal health. Relatively physiological mediated promote cell proliferation differentiation, while high excessive cause oxidative stress damage even death. treatment under appropriate conditions not only produces moderate exogenous directly stimulates intracellular generation, but also regulate indirectly, which affect redox state different tissues animals. However, condition need be optimized potential mechanism NTP-mediated targets still unclear. Over past ten decades, interest application technology biology medical sciences has been rapidly growing. There significant optimism developed for wide range applications such as wound healing, oral treatment, cancer therapy, biomedical materials its safety, non-toxicity, efficiency. Moreover, combined with other methods currently hot research topic more effective effects on sterilization anti-cancer abilities. Interestingly, presented great husbandry field recent years. related complicated mechanisms, whether play critical clarified. Therefore, this review mainly summarizes health, mechanisms through antioxidant clearance growth breeding, animal-derived food fields including would biomaterials. This will provide theoretical basis promoting healthy development prevention diseases both animals human beings.

Language: Английский

---