ChemBioChem,
Journal Year:
2023,
Volume and Issue:
25(5)
Published: Dec. 15, 2023
The
abnormal
aggregation
of
proteins
is
a
significant
pathological
hallmark
diseases,
such
as
the
amyloid
formation
associated
with
fused
in
sarcoma
protein
(FUS)
frontotemporal
lobar
degeneration
and
amyotrophic
lateral
sclerosis
diseases.
Understanding
which
cellular
components
how
these
regulate
process
living
organisms
crucial
for
prevention
treatment
neurodegenerative
MOAG-4/SERF
conserved
family
rich
positive
charged
residues,
was
initially
identified
an
enhancer
amyloids
C.
elegans.
Knocking
out
SERF
impedes
various
proteins,
including
α-synuclein
β-amyloid,
are
linked
to
Parkinson's
Alzheimer's
respectively.
However,
recent
studies
revealed
exhibited
dual
functions,
it
could
both
promote
inhibit
fibril
disease-related
amyloidogenic
proteins.
connection
between
functions
structure
basis
regulating
still
unclear.
This
review
will
outline
summarize
contradictory
role
promoting
inhibiting
finally
explore
potential
structural
functional
selectivity
protein.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: May 3, 2023
Neuropsychiatric
disorders
are
multifactorial
with
diverse
aetiological
factors.
Identifying
treatment
targets
is
challenging
because
the
diseases
resulting
from
heterogeneous
biological,
genetic,
and
environmental
Nevertheless,
increasing
understanding
of
G
protein-coupled
receptor
(GPCR)
opens
a
new
possibility
in
drug
discovery.
Harnessing
our
knowledge
molecular
mechanisms
structural
information
GPCRs
will
be
advantageous
for
developing
effective
drugs.
This
review
provides
an
overview
role
various
neurodegenerative
psychiatric
diseases.
Besides,
we
highlight
emerging
opportunities
novel
GPCR
address
recent
progress
development.
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
99, P. 102357 - 102357
Published: June 1, 2024
Neurodegenerative
disorders
(NDs)
are
expected
to
pose
a
significant
challenge
for
both
medicine
and
public
health
in
the
upcoming
years
due
global
demographic
changes.
NDs
mainly
represented
by
degeneration/loss
of
neurons,
which
is
primarily
accountable
severe
mental
illness.
This
neuronal
degeneration
leads
many
neuropsychiatric
problems
permanent
disability
an
individual.
Moreover,
tight
junction
brain,
blood-brain
barrier
(BBB)has
protective
feature,
functioning
as
biological
that
can
prevent
medicines,
toxins,
foreign
substances
from
entering
brain.
However,
delivering
any
medicinal
agent
brain
(i.e.,
Multiple
sclerosis,
Alzheimer's,
Parkinson's,
etc.)
enormously
challenging.
There
approved
therapies
address
NDs,
but
most
them
only
help
treat
associated
manifestations.
The
available
have
failed
control
progression
certain
factors,
i.e.,
BBB
drug-associated
undesirable
effects.
extremely
complex
pathology,
with
pathogenic
mechanisms
involved
initiation
progression;
thereby,
limited
survival
rate
has
been
observed
ND
patients.
Hence,
understanding
exact
mechanism
behind
crucial
developing
alternative
approaches
improving
patients'
rates.
Thus,
present
review
sheds
light
on
different
cellular
novel
therapeutic
their
clinical
relevance,
will
assist
researchers
alternate
strategies
limitations
conventional
therapies.
current
work
offers
scope
into
near
future
improve
approach
NDs.
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(1)
Published: Jan. 1, 2025
ABSTRACT
Neurodegenerative
diseases
are
significant
health
concerns
that
have
a
profound
impact
on
the
quality
and
duration
of
life
for
millions
individuals.
These
characterized
by
pathological
changes
in
various
brain
regions,
specific
genetic
mutations
associated
with
disease,
deposits
abnormal
proteins,
degeneration
neurological
cells.
As
neurodegenerative
disorders
vary
their
epidemiological
characteristics
vulnerability
neurons,
treatment
these
is
usually
aimed
at
slowing
disease
progression.
The
heterogeneity
environmental
factors
involved
process
neurodegeneration
makes
current
methods
inadequate.
However,
existence
common
molecular
mechanisms
pathogenesis
may
allow
development
new
targeted
therapeutic
strategies.
Oxidative
nitrosative
stress
damages
membrane
components
accumulating
ROS
RNS
disrupting
redox
balance.
This
results
induction
apoptosis,
which
important
through
oxidative
stress.
Studies
conducted
using
postmortem
human
samples,
animal
models,
cell
cultures
demonstrated
stress,
apoptosis
crucial
such
as
Alzheimer's,
Parkinson's,
Multiple
Sclerosis,
amyotrophic
lateral
sclerosis,
Huntington's
disease.
excessive
production
reactive
oxygen
nitrogen
species,
elevated
levels
free
radicals,
heightened
mitochondrial
disturbances
energy
metabolism,
oxidation
nitrosylation
cellular
macromolecules
recognized
triggers
neuronal
death.
Challenges
managing
treating
require
better
understanding
this
field
level.
Therefore,
review
elaborates
apoptosis.
Traffic,
Journal Year:
2024,
Volume and Issue:
25(9)
Published: Sept. 1, 2024
ABSTRACT
Mitochondria,
the
dynamic
organelles
responsible
for
energy
production
and
cellular
metabolism,
have
metabolic
function
of
extracting
from
nutrients
synthesizing
crucial
metabolites.
Nevertheless,
recent
research
unveils
that
intercellular
mitochondrial
transfer
by
tunneling
nanotubes,
tumor
microtubes,
gap
junction
communication,
extracellular
vesicles,
endocytosis
cell
fusion
may
regulate
within
recipient
cells,
potentially
contributing
to
disease
treatment,
such
as
nonalcoholic
steatohepatitis,
glioblastoma,
ischemic
stroke,
bladder
cancer
neurodegenerative
diseases.
This
review
introduces
principal
approaches
examines
its
role
in
various
Furthermore,
we
provide
a
comprehensive
overview
inhibitors
activators
transfer,
offering
unique
perspective
illustrate
relationship
between
The Journal of Physiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
Mitochondria
are
a
cell's
powerhouse
and
also
have
vital
part
in
cellular
processes.
The
emerging
role
of
mitochondria
several
crucial
processes
highlights
their
physiological
importance.
Mitochondrial
homeostasis
mechanisms,
including
proteostasis
pathways,
for
mitochondrial
health.
Failure
these
has
an
important
establishment
numerous
complex
disease
conditions,
such
as
neurodegeneration
imperfect
ageing.
However,
details
impairments
contribution
to
the
pathology
poorly
understood.
This
review
systematically
discusses
involvement
mechanisms
rejuvenating
health
fitness.
We
focus
on
various
protein
quality
control
essential
how
failure
leads
functional
disturbances
observed
conditions.
discuss
recent
findings
based
mitostasis-associated
chaperones,
mitoproteases,
autophagy
responses,
which
can
lead
emergence
new
possible
therapeutic
interventions
against
diseases.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 25, 2025
Neurodegenerative
diseases,
characterized
by
the
loss
or
damage
of
neurons,
represent
a
growing
global
health
concern.
Plants
are
rich
source
naturally
occurring
compounds
with
immense
therapeutic
potential.
Among
them,
Aquilaria
crassna
(commonly
known
as
agarwood)
is
precious
fragrant
plant
extensively
used
in
cosmetics,
perfumes,
and
traditional
Asian
medicine.
However,
its
neuroprotective
role,
particularly
neuroregeneration,
has
been
minimally
explored.
This
study
aimed
to
investigate
potential
agarwood
leaves
promoting
focus
on
cholinergic
function
neural
differentiation.
To
identify
bioactive
compounds,
comprehensive
LC–MS
analysis
was
conducted
ethanolic
extract
(AWE).
The
phytochemicals
detected
were
further
evaluated
using
silico
methods
predict
their
interaction
receptor
proteins
linked
neurodegenerative
diseases.
Virtual
screening
revealed
that
several
AWE
exhibited
strong
binding
affinities
receptors
such
sigma-1,
TrkB,
Nogo-66,
p75NTR,
providing
insights
into
mechanisms
underlying
effects.
in-silico
findings
validated
through
vitro
experiments
HT-22
mouse
hippocampal
cells
model.
treatment
led
dose-dependent
increase
expression
marker
associated
differentiation
regeneration,
including
neuronal
nuclei
(NeuN),
growth-associated
protein
43
(GAP43),
synaptophysin
(Syn),
brain-derived
neurotrophic
factor
(BDNF),
sigma-1
receptor.
Additionally,
enhanced
specific
markers
for
demonstrating
influence
development
synaptic
function.
These
provide
compelling
evidence
AWE's
properties,
highlighting
agent
Cells,
Journal Year:
2025,
Volume and Issue:
14(7), P. 525 - 525
Published: April 1, 2025
Alzheimer’s
disease
(AD)
is
a
multifactorial
neurodegenerative
disorder
characterized
by
metabolic
dysregulation,
oxidative
stress,
amyloid-β
(Aβ)
aggregation,
metal
dyshomeostasis,
and
mitochondrial
dysfunction.
Current
treatments
provide
only
symptomatic
relief,
highlighting
the
need
for
novel
therapeutic
strategies.
This
study
investigates
effects
of
alkaloids
galantamine
(GAL)
lycorine
(LYC)
in
differentiated
SH-SY5Y
neuroblastoma
cells,
an
established
vitro
model
AD,
which
acquire
neuronal
phenotype
upon
differentiation.
Using
untargeted
targeted
NMR-based
metabolomics
combined
with
multivariate
statistical
analysis,
we
analyzed
extracellular
profiles
under
basal
conditions
following
Aβ42
exposure,
both
presence
absence
GAL
LYC.
Our
findings
reveal
distinct
responses
to
Aβ
toxicity,
significant
alterations
pyruvate
glutamine
metabolism.
Both
LYC
contributed
restoration
lysine
homeostasis,
but
had
more
pronounced
effect,
better
sustaining
cellular
energy
balance
function.
Unlike
LYC,
treatment
was
associated
accumulation,
response
between
two
compounds.
These
variations
may
reflect
mechanisms
action,
potentially
influencing
their
roles
counteracting
Aβ-induced
toxicity.
highlights
value
profiling
assessing
neuroprotective
agents
reinforces
potential
natural
this
context.
