Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: Oct. 12, 2024
Language: Английский
Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: Oct. 12, 2024
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 202, P. 115108 - 115108
Published: Sept. 27, 2023
Language: Английский
Citations
56International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129901 - 129901
Published: Feb. 3, 2024
Language: Английский
Citations
15Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 105996 - 105996
Published: July 31, 2024
Language: Английский
Citations
9ACS Omega, Journal Year: 2024, Volume and Issue: 9(28), P. 29983 - 29993
Published: July 5, 2024
At present, economic development and daily life cannot be separated from organic synthetic polymers. However, a large number of nondegradable polymers have caused serious pollution to the environment. It is necessary for sustainable use biodegradable materials instead traditional polymers, but it not yet comparable in performance cost competitor will replace. Therefore, there long way go develop effective synthesis methods. Through ring-opening polymerization, some cyclic monomers, such as ε-caprolactone or lactide, can synthesized into which only replace fields also applications drug delivery, surgical consumables, human implant materials, bone etc. Ring-opening polymerization potential candidate solving environmental pollution. For catalysts are very important, among titanium attracted much attention because their high efficiency, economy, nontoxicity. In this paper, status organotitanium compounds reviewed, including effects different ligand structures on behavior polymer structure, its trend prospected. We hope that review helpful developing efficient catalysts.
Language: Английский
Citations
6European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 196, P. 106733 - 106733
Published: Feb. 24, 2024
Microencapsulation of active pharmaceutical ingredients (APIs) for preparation long acting injectable (LAI) formulations is an auspicious technique to enable preclinical characterization a broad variety APIs, ideally independent their physicochemical and pharmacokinetic (PK) characteristics. During early API discovery, tunable LAI may pharmacological proof-of-concept the given candidates by tailoring level plasma exposure over duration various timespans. Although numerous reports on small scale methods LAIs utilizing copolymers lactic glycolic acid (PLGA) polymers (PLA) highlight potential, application in formulation screening use vivo studies yet very limited. Transfer from downscale experiments hampered large number with simultaneously limited available amount lower sub-gram scale, lack stability deficient tunability sustained release. We hereby present novel comprehensive platform tool tailored extended-release formulations, aiming support ranging required levels A small-scale spray drying process was successfully implemented using air brush based instrument PLGA PLA formulations. Using Design Experiments (DoE), 250 mg demonstrated suffice identification dominant polymer characteristics largest impact release capability individual API. BI-3231, hydrophilic weakly acidic compound good water solubility permeability, but low metabolic stability, used as exemplary model one many during discovery. Furthermore, vitro correlation (IVIVC) rate established mice, which enabled prediction concentration plateaus after single subcutaneous injection, only dissolution profiles screened By doses acute sub-chronic experiments, we demonstrate practical BI-3231. Pharmacological could be whilst circumventing need multiple administration result extensive hepatic metabolism superseding tailoring.
Language: Английский
Citations
3Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 15(4), P. 1156 - 1180
Published: Dec. 11, 2024
Language: Английский
Citations
3Published: Jan. 1, 2025
Language: Английский
Citations
0Published: Jan. 1, 2025
Language: Английский
Citations
0Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113758 - 113758
Published: April 1, 2025
Language: Английский
Citations
0Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114906 - 114906
Published: June 5, 2023
Language: Английский
Citations
8