Exploring Piperine: Unleashing the multifaceted potential of a phytochemical in cancer therapy DOI
Devika Tripathi, Tanya Gupta, Prashant Kumar Pandey

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Oct. 12, 2024

Language: Английский

Revolutionizing drug formulation development: The increasing impact of machine learning DOI
Zeqing Bao,

Jack Bufton,

Riley J. Hickman

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 202, P. 115108 - 115108

Published: Sept. 27, 2023

Language: Английский

Citations

58
Stimuli responsiveness of recent biomacromolecular systems (concept to market): A review DOI
Davinder Singh, Yashika Sharma, Divya Dheer

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129901 - 129901

Published: Feb. 3, 2024

Language: Английский

Citations

15
Long acting injectables for the treatment of prostate cancer DOI
Dimple Modi, Md Sadique Hussain,

Swetha Ainampudi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 105996 - 105996

Published: July 31, 2024

Language: Английский

Citations

9
Recent Advances in the Titanium-Based Catalysts for Ring-Opening Polymerization DOI Creative Commons
Wei Wang

ACS Omega, Journal Year: 2024, Volume and Issue: 9(28), P. 29983 - 29993

Published: July 5, 2024

At present, economic development and daily life cannot be separated from organic synthetic polymers. However, a large number of nondegradable polymers have caused serious pollution to the environment. It is necessary for sustainable use biodegradable materials instead traditional polymers, but it not yet comparable in performance cost competitor will replace. Therefore, there long way go develop effective synthesis methods. Through ring-opening polymerization, some cyclic monomers, such as ε-caprolactone or lactide, can synthesized into which only replace fields also applications drug delivery, surgical consumables, human implant materials, bone etc. Ring-opening polymerization potential candidate solving environmental pollution. For catalysts are very important, among titanium attracted much attention because their high efficiency, economy, nontoxicity. In this paper, status organotitanium compounds reviewed, including effects different ligand structures on behavior polymer structure, its trend prospected. We hope that review helpful developing efficient catalysts.

Language: Английский

Citations

6
Miniaturized screening and performance prediction of tailored subcutaneous extended-release formulations for preclinical in vivo studies DOI Creative Commons
Marco Block,

Peter Sieger,

Cornelius Truenkle

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 196, P. 106733 - 106733

Published: Feb. 24, 2024

Microencapsulation of active pharmaceutical ingredients (APIs) for preparation long acting injectable (LAI) formulations is an auspicious technique to enable preclinical characterization a broad variety APIs, ideally independent their physicochemical and pharmacokinetic (PK) characteristics. During early API discovery, tunable LAI may pharmacological proof-of-concept the given candidates by tailoring level plasma exposure over duration various timespans. Although numerous reports on small scale methods LAIs utilizing copolymers lactic glycolic acid (PLGA) polymers (PLA) highlight potential, application in formulation screening use vivo studies yet very limited. Transfer from downscale experiments hampered large number with simultaneously limited available amount lower sub-gram scale, lack stability deficient tunability sustained release. We hereby present novel comprehensive platform tool tailored extended-release formulations, aiming support ranging required levels A small-scale spray drying process was successfully implemented using air brush based instrument PLGA PLA formulations. Using Design Experiments (DoE), 250 mg demonstrated suffice identification dominant polymer characteristics largest impact release capability individual API. BI-3231, hydrophilic weakly acidic compound good water solubility permeability, but low metabolic stability, used as exemplary model one many during discovery. Furthermore, vitro correlation (IVIVC) rate established mice, which enabled prediction concentration plateaus after single subcutaneous injection, only dissolution profiles screened By doses acute sub-chronic experiments, we demonstrate practical BI-3231. Pharmacological could be whilst circumventing need multiple administration result extensive hepatic metabolism superseding tailoring.

Language: Английский

Citations

3
Long-acting parenteral formulations of hydrophilic drugs, proteins, and peptide therapeutics: mechanisms, challenges, and therapeutic benefits with a focus on technologies DOI Creative Commons

Deepa D. Nakmode,

Baljinder Singh, Sadikalmahdi Abdella

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 15(4), P. 1156 - 1180

Published: Dec. 11, 2024

Language: Английский

Citations

3
Oil-Based Long-Acting Injectable Systems: Formulation Insights and Future Perspectives DOI
Niranjan G. Kotla,

Samaneh Validi,

Farshad Ramazani

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Envisaging the Future of Long-Acting Injectables and Implants DOI
Farshad Ramazani,

Andreas Fisch,

Bernd Riebesehl

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
PLGA-based long-acting injectable (LAI) formulations DOI
Kinam Park

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113758 - 113758

Published: April 1, 2025

Language: Английский

Citations

0
From in vitro to in vivo: A comprehensive guide to IVIVC development for long-acting therapeutics DOI
Giorgia Pastorin, Camillo Benetti, Matthias G. Wacker

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114906 - 114906

Published: June 5, 2023

Language: Английский

Citations

8